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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Results. Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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A Case Study to Identify the Hindrances to Widespread Adoption of Electric Vehicles in Qatar
Published 2020“…<p dir="ltr">The adoption of electric vehicles (EVs) have proven to be a crucial factor to decreasing the emission of greenhouse gases (GHG) into the atmosphere. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Effect of Acute and Chronic Moderate Red or White Wine Consumption on Fasted and Postprandial Lipemia in the Rat
Published 2006“…The effects of acute and chronic (10 wk) red or white wine consumption on fasted and postprandial lipemia in the rat model are reported. …”
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A stochastic dominance test under survey nonresponse with an application to comparing trust levels in Lebanese public institutions
Published 2020“…Stochastic dominance comparisons of distributions based on ordinal data arise in many areas of economics. This paper develops a testing procedure for such comparisons under survey sampling from large finite populations with nonresponse using the worst-case bounds of the distributions. …”
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High-sensitive detection and quantitation of thyroid-stimulating hormone (TSH) from capillary/fingerstick and venepuncture whole-blood using fluorescence-based rapid lateral flow i...
Published 2023“…BackgroundIn the last decade, point of care testing (POCT) such as lateral flow immunoassays (LFIA) were developed for rapid TSH measurement. …”
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A case of cat-scratch disease with unusual ophthalmic manifestations
Published 2012“…We report a case of cat-scratch disease with unusual posterior segment manifestations. …”
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A potential therapeutic agent for sickle cell anaemia
Published 2016“…Also, supplementing patients with substances that possess antioxidant properties could reduce the complications of the disease,” says biochemist Lamia Al-Naama, the lead author of the paper. Substances that decrease the frequency of episodes of red blood cell destruction or employing molecular approaches that can reduce ROS production could alter the course of the disease and the incidence of associated complications, she adds.…”
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Effect of the stretch rate during uniaxial testing on the mechanical properties of prolene
Published 2017“…Of the mechanical properties of special significance are the following three properties: peak load (N), extension (%) at peak load, and linear stiffness (N/mm). Uniaxial tensile testing was performed on mesh samples on a universal testing machine and involved loading different samples at 5 cross-head speeds of: 1, 10, 50, 100, and 500 mm/min. …”
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Underrepresentation of racial and ethnic minorities in cascade testing for hereditary cancer syndromes
Published 2023“…Cascade testing is critical as relatives found to carry a pathogenic gene variant have the opportunity to pursue targeted cancer risk reduction and early detection, decreasing cancer-associated morbidity and mortality. …”
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Adopting Geophysical Testing Techniques in Geotechnical Investigation and Shallow Foundation Design
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Acute spasticity in malignant MCA stroke: a case report and review of literature
Published 2025“…However, an acute onset of spasticity at presentation is extremely rare. We report a case of a 40-year-old male patient who presented with spasticity accompanied by aphasia and decreased consciousness. …”
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A Severe Case of Overlap of Morphea and Eosinophilic Fasciitis after Burn Injuries
Published 2024“…The coexistence of the two is extremely rare and has a poorer prognosis. Our case report is one of the first to report burn injuries as a trigger factor for EF and generalized morphea overlap. …”
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