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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate
منشور في 2025"…Live cell assays revealed a cleavage sequence length-dependent resonance energy transfer, except for the 12× -syn cleavage site, and an increased rate of cleavage and a decreased pharmacological inhibitor efficacy for the Mpro biosensor containing 2× cleavage sequences. …"
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Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?
منشور في 2021"…The Renin-Angiotensin System (RAS) is activated in type 2 diabetes (T2D); therefore, the aim of this study was to determine if hypoglycaemia-induced stress in T2D would potentiate serum NRP1(sNRP1) levels, reflecting an increased risk for SARS-CoV-2 infection.…"
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Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage
منشور في 2018"…Increased glucose entry into glycolysis in fibroblast senescence is mainly mediated by increased hexokinase-2. …"
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Application of Fe<sub>3</sub>O<sub>4</sub> magnetite nanoparticles grafted in silica (SiO<sub>2</sub>) for oil recovery from oil in water emulsions
منشور في 2021"…An excellent %<sub>hdem</sub> 90% was achieved C<sub>oil</sub> in the range 50 e2000 mg/L. Using an MD<sub>dose</sub> as low as 10 mg/L attained a %<sub>hdem</sub> in the range of 93% - 4.3% for O/W mixtures with C<sub>oil</sub> < 2000 mg/L, which slightly decreased to ~90% for higher concentrations. …"
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
منشور في 2024"…Further, analysis of trajectories for <u>hydrogen bonds</u> (H-bonds) formed between NLuc and furimazine revealed substantial H-bond interaction between R162 and Q32 residues. Mutation of the two residues in NLuc revealed a decreased but stable activity of the R162A, but not Q32A, mutant NLuc in live cell and in vitro assays performed using lysates prepared from cells expressing the proteins and with the furimazine substrate. …"
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Correlating the rheological and magneto-optical properties of cobalt substituted magnetite ferrofluids (Co<sub>x</sub>Fe<sub>1−x</sub>Fe<sub>2</sub>O<sub>4</sub>) with theoretical...
منشور في 2023"…Faraday rotation of Co<sub>x</sub>Fe<sub>1−x</sub>Fe<sub>2</sub>O<sub>4</sub> ferrofluids is measured depending on the different concentrations of cobalt in applied magnetic field. …"
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The emergence of new SARS-CoV-2 variant (Omicron) and increasing calls for COVID-19 vaccine boosters-The debate continues
منشور في 2022"…<p dir="ltr">The emergence of highly mutated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant Omicron (B.1.1.529) has ushered panic responses around the world due to its contagious and vaccine escape mutations. …"
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iPSCs derived from insulin resistant offspring of type 2 diabetic patients show increased oxidative stress and lactate secretion
منشور في 2022"…IR-iPSCs have increased cellular oxidative stress indicated by a high production of reactive oxygen species and higher susceptibility to H2O2 -induced apoptosis.…"
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A new insight into the separation of oil from oil/water emulsion by Fe<sub>3</sub>O<sub>4</sub>–SiO<sub>2</sub> nanoparticles
منشور في 2021"…For the oil recovery process, the Fe<sub>3</sub>O<sub>4</sub> was applied for the inhibition (i.e., decrease) of oil sedimentation, and the SiO<sub>2</sub> NPs were applied for wettability alteration and IFT reduction. …"
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Cardiac phosphodiesterases are differentially increased in diabetic cardiomyopathy
منشور في 2021"…Moreover, we noted an early and specific upregulation of cardiac PDE1A, PDE2A, PDE4B, PDE4D and PDE5A expression at week 4, followed by increases in PDE3A levels in diabetic hearts at week 8. …"
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
منشور في 2023"…From this and previous transcriptomic studies, signaling involved in enhanced removal of MG-modified protein is likely increased HSPB1-directed HUWE1 ubiquitination through eIF2α-mediated, ATF5-induced increased expression of HSPB1. …"
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
منشور في 2023"…From this and previous transcriptomic studies, signaling involved in enhanced removal of MG-modified protein is likely increased HSPB1-directed HUWE1 ubiquitination through eIF2α-mediated, ATF5-induced increased expression of HSPB1. …"
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Application of Zn-ferrite towards thermochemical utilization of carbon dioxide: A thermodynamic investigation
منشور في 2021"…The decrease in the reduction temperature is significant when the ratio of the molar flow rate of inert sweep gas to the molar flow rate of ZnFe<sub>2</sub>O<sub>4</sub> increases from 10 to 30. …"
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