Analysis of AMPA-R mediated EPSCs (aEPSCs) at CA1 synapses in hippocampal slices from P10 mice ICV injected at P1, P3, and P5 with saline or GR1. by Nicole M. Lykens (3727072)

“…<b>(d)</b> Rectification index of aEPSC amplitude was moderately decreased after SMO treatment (n = 8; p = 0.017). For panels <b>c</b> and <b>d</b> saline and GR1 representative half-maximal initial aEPSC traces or aEPSCs recorded at -70 mV respectively are normalized to the same amplitude (scale bar: 50 ms). …”

<i>E</i>. <i>chaffeensis</i> TRP120 HECT E3 Ub ligase activity mediates K48 ubiquitination and degradation of FBW7. by Jennifer Y. Wang (8787527)

“…Densitometry values of FBW7 for each time point were denoted above respective bands (ctrl: 1.4 ±0.03; 24 hpt: 1.3±0.08; 48 hpt: 0.5±0.09), with Significantly (<i>p</i><0.05) decreased levels of FBW7 were detected at 48 hpt with TRP120 compared to control (n = 3). …”

Consistent Effects of Hypoglycemia on Cognitive Function in People With or Without Diabetes by Clementine E.M. Verhulst (12889592)

“…</p> <p><strong>RESULTS</strong> For the whole group, hypoglycemia decreased the proportion of correct answers on the PASAT by 8.4 ± 12.8%, increased the mean reaction time on the TAP Alertness task by 32.1 ± 66.6 ms, and increased the sum of errors and omissions on the TAP Working Memory task by 2.0 ± 5.5 (all <em>p </em>< 0.001). …”

Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides by Guanghui Yi (201792)

“…The cyclic dinucleotides can be bacterial second messengers c-di-GMP and c-di-AMP, 3’5’-3’5’ cyclic GMP-AMP (3’3’ cGAMP) produced by <i>Vibrio cholerae</i> and metazoan second messenger 2’5’-3’5’ Cyclic GMP-AMP (2’3’ cGAMP). …”

A Concept of Bayesian Regulation in Fisheries Management - Figure 1 by Noél Michael André Holmgren (653777)

“…If the variance is lower than the mean, the posterior mean will decrease with accumulating catches and effort. …”

OE33 R cells display alterations in mitochondrial-associated gene expression, total cellular energy and energy metabolism pathways. by Niamh Lynam-Lennon (589291)

“…<p>(A) Basal expression of 15 mitochondrial function and energy metabolism-associated genes were altered 1.5-fold in OE33 R cells, when compared to OE33 P. …”

Fig 2 - by Hina Mushtaq (14885903)

“…Isolate HM49 recorded its protease enzyme activity from pH 6 (lowest) reaching its optimum at pH 8 followed by a gradual decrease up to pH 12 (2D). Temperature studies revealed its dynamism broadly in 5°C (lowest) to 40 °C range with its optimum activity being recorded at 20 °C (2E). …”

Expression of BMPs and their endogenous inhibitors during progression and reversal of chronic kidney disease. by Anne-Cécile Huby (5653777)

“…Values are mean±SEM; n = 5, 9 and 13 for wild type and RenTg mice before and after irbesartan, respectively; * P<0,05 or ** P<0,01 vs WT; ^# P<0,05 or ^## P<0,001 vs RenTg.…”

Data Sheet 1_Case series: Effects of a ketogenic diet on cardiometabolic health in seven outpatients with bipolar disorder.pdf by Louis Schreel (22385035)

“…</p>Results<p>Beneficial cardiometabolic effects included a decrease in mean Lp(a) of 6.6 mg/dl (−21%), a reduction in mean triglyceride of 40.6 mg/dl (−30%), a reduction in mean apoB of 0.14 g/L (−10,5%) and an increase in mean HDL-C of 3 mg/dL (+5%), a reduction in mean hsCRP of 0.94 mg/L (−45%), a reduction in mean TNF-α of 1.31 pg/ml (−7%), a reduction in mean MDA-LDL of 36.77 U/L (−38%), a reduction in mean nitrotyrosine of 225 nmol/L (−28%), a mean weight reduction of 4 kg (−4,6%), a mean visceral fat reduction of 0.69% (−10%) and a mean fat mass reduction of 3.7 kg (−12%). …”

Reducing healthcare-associated infections incidence by a probiotic-based sanitation system: A multicentre, prospective, intervention study by Elisabetta Caselli (304287)

“…PCHS was associated with a significant decrease of HAI cumulative incidence from a global 4.8% (284 patients with HAI over 5,930 total patients) to 2.3% (128 patients with HAI over 5,531 total patients) (OR = 0.44, CI 95% 0.35–0.54) (P<0.0001). …”

Ara-C-induced Mcl-1 degradation and cell death are inhibited upon TPA-induced ERK activation in BL41-3 cells. by Shanna K. Nifoussi (128297)

“…A representative experiment is included (upper photograph) along with the average (± SE) of 5 independent experiments. Also shown for comparative purposes is the percentage of cells exhibiting morphological apoptosis, assayed with a concentration of 1 nM TPA applied 1 hour before the addition of Ara-C (mean of 3 independent experiments ± SE run in parallel with previous studies; some of the BL41-3 cell samples not treated with TPA were included in a previous publication comparing these to BL41 parental cells (Fig. 4 in reference <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0047060#pone.0047060-Vrana2" target="_blank">[23]</a>). …”

Metformin reduces lipid stores and causes intestinal fluid imbalance. by Cathy Slack (251729)

“…(<b>B</b>) Metformin treatment of female flies does not affect the number of fecal deposits produced per fly over a 24 hour period (<i>P>0.05</i>, Wilcoxen test, n = 5 (5 flies per replicate)). (<b>C</b>) Metformin treatment of female flies does not affect the size of fecal deposits as measured by the mean area of deposits (<i>P>0.05</i>, Wilcoxen test, n = 5 (5 flies per replicate)). …”

Distribution of modulated genes. by Doreswamy Kenchegowda (135193)

“…<p>Numbers of unique characterized genes which are differentially expressed in <i>Klf5</i>CN vs. WT corneas at PN11 or at PN56 (rows) are shown. …”

DataSheet1_The Efficacy and Safety of Pulmonary Vasodilators in Pediatric Pulmonary Hypertension (PH): A Systematic Review and Meta-analysis.docx by Tingting Shu (353149)

“…In total, compared with the control group treatment, pulmonary vasodilators significantly decreased the mortality (p = 0.002), mean pulmonary artery pressure (mPAP, p = 0.02), and mechanical ventilation duration (p = 0.03), also improved the oxygenation index (OI, p = 0.01). …”

Chemical Composition, Synergistic Antimicrobial and Antioxidant Potential of <i>Hibiscus rosa-sinensis</i> L. Leaves Essential Oil and Its Major Compound by Ramneek Sidhu (15408052)

“…Moreover, the essential oil exhibited synergistic interaction with standard antimicrobials with a 3.75 to 10 times decrease in their MIC values. The essential oil also exhibited median inhibitory concentration (IC₅₀) values of 780, 800, and 860 μg/mL in DPPH, NO, and ABTS free radical scavenging assays respectively. …”

Data_Sheet_1_Microbial Interactions With Dissolved Organic Matter Drive Carbon Dynamics and Community Succession.docx by Xiaoqin Wu (470428)

“…In this study, we fed sediment-derived dissolved organic matter (DOM) to groundwater microbes and continually analyzed microbial transformation of DOM over a 50-day incubation. To document fine-scale changes in DOM chemistry, we applied high-resolution Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) and soft X-ray absorption spectroscopy (sXAS). …”

Epitope mapping of 2E1 by hydrogen/deuterium-exchange mass spectrometry. by Zhifeng Chen (2340808)

“…<p>(A) Heat map plot showing the difference in deuteration levels of the RSV prefusion F protein alone compared to RSV prefusion F protein in the presence of the 2E1 monovalent Fab at five time points (15, 50, 150, 500, and 1500 sec). Slower deuterium exchange indicates regions containing the binding sites. …”

Potential impact of the cleft potential on presynaptic calcium currents. by Martijn C. Sierksma (11608174)

“…Scale bar: 200 mV, 40 mV, 50 mV, 1 nA. (B) Relation between peak calcium currents and leak resistance for the two APs. …”

Influence of acute slice preparation protocols on receptor subcellular localization and basal interneuron activity in the CA1 area. by Xavier Rezai (5656768)

“…C: Representative traces showing the difference in sIPSCs frequency recorded in CA1 pyramidal cell using the classical, sucrose or High K+ slice preparation protocol. Scale bar: 500 ms/50 pA. D: Histogram showing the difference of sIPSCs frequency recorded in CA1 pyramidal cell in different conditions. …”

DataSheet1_Profiling of the serum MiRNAome in pediatric egyptian patients with wilms tumor.PDF by Fatma S. Mohamed (19850220)

“…The ROC curve analysis revealed that multiple dysregulated miRNAs in WT, specifically hsa-miR-7-5p, hsa-miR-146a-5p, hsa-miR-378a-3p, and hsa-miR-483-5p, exhibited high diagnostic potential for WT, with AUC values exceeding 0.86. …”