53 proteins change in abundance with age. by Stephanie M. Zimmerman (449532)

<i>In-silico</i> identification of fingerprint of pyrazolyl sulfonamide responsible for inhibition of <i>N</i>-myristoyltransferase using Monte Carlo method with index of ideality... by Ashwani Kumar (55732)

“…The mechanistic interpretation of developed models explains the role of different structural attributes in predicting the pIC₅₀ of pyrazole sulfonamides extracted from the crystal structure of Leishmania major N-myristoyltransferase (NMT) along with co-crystallized myristoyl-CoA and ligands NMT106, NMT157, NMT187 and NMT236 (PDB ID: 4A2Z, 4A30, 4A32, 2WSA). …”

The Protein <i>O</i>-glucosyltransferase Rumi Modifies Eyes Shut to Promote Rhabdomere Separation in <i>Drosophila</i> by Amanda R. Haltom (664189)

“…The intracellular accumulation of Eys and the IRS defect worsen in <i>rumi</i> mutants raised at a higher temperature, and are accompanied by a ∼50% decrease in the total level of Eys. …”

Presentation_1_Dysfunctional LAT2 Amino Acid Transporter Is Associated With Cataract in Mouse and Humans.pdf by Emilia Boiadjieva Knöpfel (6795341)

“…We show that neutral amino acid antiporter LAT2 (Slc7a8) and uniporter TAT1 (Slc16a10) are expressed on mouse ciliary epithelium and LAT2 also in lens epithelium. …”

Quantification of Membrane and Membrane-Bound Proteins in Normal and Malignant Breast Cancer Cells Isolated from the Same Patient with Primary Breast Carcinoma by Xiquan Liang (1867900)

“…More than 50% of all major drug targets are membrane proteins, and their role in cell−cell interaction and signal transduction is a vital concern. …”

Quantification of Membrane and Membrane-Bound Proteins in Normal and Malignant Breast Cancer Cells Isolated from the Same Patient with Primary Breast Carcinoma by Xiquan Liang (1867900)

“…More than 50% of all major drug targets are membrane proteins, and their role in cell−cell interaction and signal transduction is a vital concern. …”

Data Sheet 1_Milciclib-mediated CDK2 inhibition to boost radiotherapy sensitivity in colorectal cancer.pdf by Junjie Ma (730463)

“…When combined with irradiation, Milciclib led to a 20% increase in the proportion of cells in the G1 phase and a 10% decrease in the G2 phase, suggesting an alteration in cell cycle distribution. …”

DataSheet_1_Systematic review and meta-analysis of the current literature on tocilizumab in patients with refractory Takayasu arteritis.docx by Limei Kang (14584889)

“…Approximately 76% (95% CI 58-87%) of patients achieved a decrease in glucocorticoid dosage. Meanwhile, patients with TAK had a remission rate of 79% (95% CI 69-86%), a relapse rate of 17% (95% CI 5-45%), an imaging progress rate of 16% (95% CI 9-27%), and a retention rate of 68% (95% CI 50-82%). …”

Table_1_The Impact of COVID-19 Confinement on Tinnitus and Hearing Loss in Older Adults: Data From the LOST in Lombardia Study.DOCX by Carlotta Micaela Jarach (12203687)

“…In 2020 compared to 2019, among individuals with tinnitus, those with increasing severity (5.0%) were similar to those decreasing it (5.3%). …”

Crz signaling influences osmotic and ionic stresses. by Meet Zandawala (491178)

Robotic Thoracic Enucleation of Esophageal Leiomyoma by João Marcelo Lopes Toscano de Brito (11458365)

“…Because of the lesion’s anterior position relative to the trachea, it was felt it might be best accessed from the right chest. We also felt that potential risk of left recurrent laryngeal nerve injury may be decreased with a right-sided approach.…”

DataSheet_1_Stapled peptide PROTAC induced significantly greater anti-PD-L1 effects than inhibitor in human cervical cancer cells.docx by Yu-Ying Shi (15975992)

“…</p>Methods<p>We synthesized a stapled peptide-based PROTAC (SP-PROTAC) that specifically targeted palmitoyltransferase ZDHHC3 and resulted in the decrease of PD-L1 in human cervical cancer cell lines. …”

Random Codon Re-encoding Induces Stable Reduction of Replicative Fitness of Chikungunya Virus in Primate and Mosquito Cells by Antoine Nougairede (5649739)

“…<div><p>Large-scale codon re-encoding represents a powerful method of attenuating viruses to generate safe and cost-effective vaccines. …”

Anti-Cancer Effect of Thiacremonone through Down Regulation of Peroxiredoxin 6 by Miran Jo (533723)

“…Thiacremonone (0–50 μg/ml) inhibited lung cancer cell growth in a concentration dependent manner through induction of apoptotic cell death accompanied by induction of cleaved caspase-3, -8, -9, Bax, p21 and p53, but decrease of xIAP, cIAP and Bcl2 expression. …”

Rapid degeneration of 5-HT neurons in SERT-Cre^cre/wt Munc18-1^lox/lox mice. by Jacobus J. Dudok (338648)

“…(O) Analysis of the number of 5-HT cell bodies in the sections showed that there is no difference at E16, but at E18 and P2 there is a decrease of 80% to 90% in the number of 5-HT cell bodies in SERT-Cre^cre/wt Munc18-1^lox/lox sections. …”

Hemodialysis-Related Glycemic Disarray Proven by Continuous Glucose Monitoring: Glycemic Markers and Hypoglycemia by Akinori Hayashi (305316)

“…</p> <p><b>RESULTS</b></p> <p>Sensor glucose level (SGL) showed a sustained decrease during HD, irrespective of the dialysate glucose concentration, and reached a nadir that was lower than the dialysate glucose concentration in 49 participants (50%). …”

DataSheet1.pdf by Robert Šket (4666972)

“…<p>We explored the metagenomic, metabolomic and trace metal makeup of intestinal microbiota and environment in healthy male participants during the run-in (5 day) and the following three 21-day interventions: normoxic bedrest (NBR), hypoxic bedrest (HBR) and hypoxic ambulation (HAmb) which were carried out within a controlled laboratory environment (circadian rhythm, fluid and dietary intakes, microbial bioburden, oxygen level, exercise). …”

Table1_Lifetime evaluation of left ventricular structure and function in male ApoE null mice after gamma and space-type radiation exposure.DOCX by Agnieszka Brojakowska (11084123)

“…This was also observed later in 100 cGy γ-IR mice at 28 days. At later stages, a significant decrease in LV systolic function was observed in the 400 cGy γ-IR mice. …”

Data Sheet 1_Association of Life’s Essential 8 with all-cause mortality in asthma patients: evidence from NHANES 2005–2018.zip by Jinqi Zhu (14374338)

“…Each one-point increase in health behavior score was linked to a 1.3% decrease in mortality risk (HR = 0.987, 95% CI: 0.982–0.992; p < 0.001). …”

DataSheet_1_Human Macrophages Exhibit GM-CSF Dependent Restriction of Mycobacterium tuberculosis Infection via Regulating Their Self-Survival, Differentiation and Metabolism.docx by Abhishek Mishra (4343047)