Phase 1 study to evaluate the effects of rifampin or itraconazole on the pharmacokinetics of limertinib (ASK120067), a novel mutant-selective inhibitor of the epidermal growth fact... by Bei Cao (141848)

“…Coadministration of itraconazole increased the AUC_0-inf of limertinib by 289.8% (GLSM ratio, 389.8%; 90% CI, 334.07–454.82), but decreased that of CCB4580030 by 35.96% (GLSM ratio, 64.04%; 90% CI, 50.78–80.77).…”

DataSheet1_The influence of drug-induced metabolic enzyme activity inhibition and CYP3A4 gene polymorphism on aumolertinib metabolism.docx by Feng Ye (173489)

“…The IC₅₀ values of telmisartan and carvedilol in CYP3A4.1 were 6.68 ± 1.76 μM and 0.60 ± 0.25 μM, respectively, whereas in CYP3A4.12, the IC₅₀ exceeded 100 μM. …”

Mass spectrum of 7-MH. by Juthamart Maneenet (15999769)

“…This study evaluated the anti-cancer potential of 7-methoxyheptaphylline (7-MH), a carbazole alkaloid from <i><i>Clausena harmandiana</i></i>, against pancreatic cancer cells (PANC-1) and developed an environmentally sustainable extraction methodology using ultrasonic-assisted extraction (UAE). 7-MH demonstrated selective cytotoxicity against PANC-1 cells with preferential activity under nutrient deprivation conditions (PC₅₀ = 4.54 μM) compared to nutrient-rich conditions (IC₅₀ = 46.84 μM). …”

ANOVA for 7-MH yield. by Juthamart Maneenet (15999769)

“…This study evaluated the anti-cancer potential of 7-methoxyheptaphylline (7-MH), a carbazole alkaloid from <i><i>Clausena harmandiana</i></i>, against pancreatic cancer cells (PANC-1) and developed an environmentally sustainable extraction methodology using ultrasonic-assisted extraction (UAE). 7-MH demonstrated selective cytotoxicity against PANC-1 cells with preferential activity under nutrient deprivation conditions (PC₅₀ = 4.54 μM) compared to nutrient-rich conditions (IC₅₀ = 46.84 μM). …”

Raw images of Western blot experiment. by Juthamart Maneenet (15999769)

“…This study evaluated the anti-cancer potential of 7-methoxyheptaphylline (7-MH), a carbazole alkaloid from <i><i>Clausena harmandiana</i></i>, against pancreatic cancer cells (PANC-1) and developed an environmentally sustainable extraction methodology using ultrasonic-assisted extraction (UAE). 7-MH demonstrated selective cytotoxicity against PANC-1 cells with preferential activity under nutrient deprivation conditions (PC₅₀ = 4.54 μM) compared to nutrient-rich conditions (IC₅₀ = 46.84 μM). …”

Data_Sheet_1_The RNA N6-Methyladenosine Methyltransferase METTL3 Promotes the Progression of Kidney Cancer via N6-Methyladenosine-Dependent Translational Enhancement of ABCD1.docx by Yue Shi (128342)

Summary of von Mises stress values from specimen FEA. by Nathan L. Wright (18389458)

datasheet1_Efficacy and Safety of Immunosuppressive Monotherapy Agents for IgA Nephropathy: A Network Meta-Analysis.docx by Shisheng Han (10019855)

“…<p>Background: The efficacy and safety of immunosuppressive monotherapy agents were evaluated for immunoglobulin A nephropathy (IgAN) using a network meta-analysis approach.…”

Differences in mean scores of upper extremity performance in all five accelerometer-derived variables across four time points- pre-HABIT, post-HABIT, 3-month, and 6-month post-HABI... by Shailesh S. Gardas (20490020)

Results from mixed-effect regression models for Stroop Blocks 1 and 2. by Nicholas P. Carruth (16469743)

Table_1_Distribution and potential risk factors of bisphenol a in serum and urine among Chinese from 2004 to 2019.docx by Wenjing Zhang (246857)

“…Background<p>Bisphenol A (BPA) is an oil-derived, large-market volume chemical with endocrine disrupting properties and reproductive toxicity. …”

Table_1_Distribution and potential risk factors of bisphenol a in serum and urine among Chinese from 2004 to 2019.docx by Wenjing Zhang (246857)

“…Background<p>Bisphenol A (BPA) is an oil-derived, large-market volume chemical with endocrine disrupting properties and reproductive toxicity. …”

Optical Control of Insect Behavior and Receptors with Azobenzene-Bridged Fipronil and Imidacloprid by Wen Fu (2040040)

“…IMI-AB-FIP in both <i>trans</i>/<i>cis</i> isomers can be reversibly interconverted depending on light, accompanied by insecticidal activity decrease or increase by 1.5–2.3 folds. In addition, IMI-AB-FIP displayed synergistic effects against A. craccivora (LC_{50, IMI‑AB‑FIP} = 14.84–22.10 μM, LC_{50, IMI‑AB‑IMI} = 210.52–266.63 μM, LC_{50, and FIP‑AB‑FIP} = 36.25–51.04 μM), mainly resulting from a conceivable reason for simultaneous targeting on both GABARs and nAChRs. …”

Table1_Integrated transcriptomics and proteomics assay identifies the role of FCGR1A in maintaining sperm fertilization capacity during semen cryopreservation in sheep.XLSX by Jiachen Bai (8449023)

“…The results showed that both the sperm viability (fresh group: 87.65% ± 4.17% vs. 75.8% ± 1.15%, cryopreserved group: 48.15% ± 0.63% vs. 42.45% ± 2.61%, p < 0.05) and motility (fresh group: 83.27% ± 4.15% vs. 70.41% ± 1.07%, cryopreserved group: 45.31% ± 3.28% vs. 35.13% ± 2.82%, p < 0.05) were significantly reduced in fresh and frozen sperm when FCGR1A was blocked. Moreover, the cleavage rate of embryos fertilized by FCGR1A-blocked sperm was noted to be significantly lower in both fresh (95.28% ± 1.16% vs. 90.44% ± 1.56%, p < 0.05) and frozen groups (89.8% ± 1.50% vs. 82.53% ± 1.53%, p < 0.05). …”

Discovery of Novel <i>N</i>‑Hydroxy-1,2,4-oxadiazole-5-formamides as ASM Direct Inhibitors for the Treatment of Atherosclerosis by Kan Yang (49193)

S1 Data - by Naeem Iqbal (1740589)

“…The current study was planned to investigate the effects of two concentrations (LC₂₅ and LC₅₀) of pyriproxyfen on biological and population parameters of a field strain of <i>M</i>. …”

Adjusted associations between positive environment swabs and household characteristics and reported behaviors. by Sheila K. West (7245476)

DataSheet_1_Lipopolysaccharide-responsive beige-like anchor is involved in regulating NF-κB activation in B cells.pdf by Daniela Pérez-Pérez (18861310)

“…The NF-κB pathway exhibited a basal activation status of several components, resulting in increased activation of p50, p65, and IκBα, basal p50 activation was reduced by the Plcγ2 inhibitor U73122. …”

Fig 2 - by Naeem Iqbal (1740589)

Auranofin (Aur) promotes cancer cell mitophagy in HeLa cells. by Sara Rodríguez-Enríquez (4373332)