<i>NDE1</i> plays a critical role in the action of binaphthoquinones. by Ashkan Emadi (248270)

“…Spot assays of wild-type, <i>nde1nde2</i>Δ, <i>nde1</i>Δ, <i>nde2</i>Δ and wild type yeast overexpressing <i>NDE1</i> driven by a GPD promoter (P<i>_GPD</i>-<i>NDE1</i>) were spotted in five fold serial dilutions on plates containing glycerol or glucose and either DMSO or BiQ7, BiQ11 or BiQ3 at their IC₅₀ concentrations. …”

A high content imaging approach was used to identify compounds that cause JLA. by Magdalena L. Circu (846722)

“…The drugs that yield an NPI score of more than 50% and a Z score of less than -4 (right lower quadrant as indicated by the red arrow) were designated as ‘hit’ compounds.…”

Dynamic Changes of Mitochondrial DNA Copy Number in Gastrointestinal Tract Cancers: A Systematic Review and Meta-Analysis by Mehdi Alikhani (278179)

The impact of a CTL-based vaccine is dependent upon the extent to which it affects transmission potential. by Helen R. Fryer (194033)

“…Our simulations are based upon an epidemic in a sub-saharan community, thus we assume a basic reproductive number of 2 in the absence of vaccination (,,years⁻¹). …”

Educational outcomes of a new curriculum on interproximal oral prophylaxis for dental students by Denis Bourgeois (225227)

“…At one week, 89.6% of subjects reported using IDBs. Individual use decreased significantly from one week to one month (-26%, p <i>=</i> 0.006) while a non-significant upward trend occurred between one month and three months. …”

Protein-protein docking for Parkin and a charged E2∼Ub complex. by Thomas R. Caulfield (655752)

“…<b>C</b>) Following unbiased MD (>200 ns), the E2-Ub complex moves towards the Parkin's active center. The decreased distance is shown after 50 ns. <b>D</b>) Overall re-orientation of the UBL domain and the E2-Ub complex is shown after 200 ns.…”

RIPK3 enhances innate anti-viral immunity against Influenza A virus. by Jeffrey Downey (3927356)

Supplementary Material for: Phosphodiesterase-5 Inhibitors and Dementia Risk: A Real-World Study by Gronich N. (18892231)

“…Similar results were obtained in a competing risk analysis, and in a sensitivity analysis in which we restricted the cohort to patients older than 60 years at cohort entry. …”

Bleeding Risk and Mortality of Edoxaban: A Pooled Meta-Analysis of Randomized Controlled Trials by Shuang Li (146392)

Statins and Hip Fracture Prevention – A Population Based Cohort Study in Women by Arja Helin-Salmivaara (123653)

“…When women with poor (<40%), moderate (40 to 80%), and good adherence (≥80%) to statins were compared to those with good adherence to hypertension drugs (≥80%) or to the population cohort, the protective effect associated with statin use attenuated with the decreasing level of adherence.</p> <h3>Conclusions</h3><p>5-year exposure to statins is associated with a reduced risk of low-energy hip fracture in women aged 50–80 years without prior hospitalizations for fractures.…”

Neoadjuvant chemotherapy for muscle invasive bladder cancer: a nationwide investigation on survival by Beth Russell (5095202)

“…This study calculated 5-year survival and risk of bladder cancer (BC)-specific and overall death by Cox proportional hazard models for the study cohort and a propensity score (PS) matched cohort.</p> <p><b>Results:</b> Those who had received NAC had higher 5-year survival proportions and decreased risk of both overall and BC specific death (HR = 0.71, 95% CI = 0.52–0.97 and HR = 0.67, 95% CI = 0.48–0.94), respectively, as compared to patients who did not receive NAC. …”

Synthesis and Preclinical Validation of Novel Indole Derivatives as a GPR17 Agonist for Glioblastoma Treatment by Phung Nguyen (230474)

“…The <b>CHBC</b>–GPR17 interaction leads to a rapid decrease of cAMP and Ca²⁺. <b>CHBC</b> exhibits the cytotoxicity effect on GBM cells in a dose-dependent manner with an IC₅₀ of 85 μM, whereas the known agonist MDL29,951 showed a negligible effect. …”

Data_Sheet_1_Effect of a High Fat Diet vs. High Carbohydrate Diets With Different Glycemic Indices on Metabolic Parameters in Male Endurance Athletes: A Pilot Trial.docx by Denise Zdzieblik (12399730)

“…The purpose of this trial was to investigate the effect of a 4-week high fat low carbohydrate (HFLC-G: ≥65% high glycemic carbohydrates per day; n = 9) vs. high carbohydrate low glycemic (LGI-G: ≥65% low glycemic carbohydrates daily; n = 10) or high glycemic (HGI-G: ≥65% fat, ≤ 50 g carbohydrates daily; n = 9) diet on fat and carbohydrate metabolism at rest and during exercise in 28 male athletes. …”

Measuring and Reducing Chemical Spills by Students: A Randomized Controlled Trial of Providing Feedback by Aimilia M. Tsokou (7272506)

“…A Hodges–Lehmann estimator for the median change in volume spilled during the second experiment due to providing feedback on spillage during first experiment was a 50% decrease in volume spilled (95% confidence range: 0 to 80% decrease, Mann–Whitney <i>U</i> test <i>p</i> = 0.05). …”

Effects of the transobturator tape procedure on overactive bladder symptoms and quality of life: a prospective study by Salih Polat (8185269)

“…Conclusions: MUS is not only a gold standard treatment in SUI but also presents as a promising treatment modality in stress-dominant MUI. …”

Glyphosate alters the composition, but not density, of the <i>A</i>. <i>gambiae</i> midgut microbiota. by Daniel F. Q. Smith (10788903)

“…Error bars represent the mean and ±SD. <b>(B)</b> Glyphosate alters the composition of the mosquito microbiota, leading to decrease of Entereobacteriacae and an increase of <i>Asaia</i> spp. …”

Raw data. by Guohui Zhao (4668682)

“…Using the YSV dynamic acceleration signal acquisition system and a portable radar speed gun collect data on racket acceleration, stress-strain signals, and ball speed from 15 male athletes. …”

The participants information. by Guohui Zhao (4668682)

“…Using the YSV dynamic acceleration signal acquisition system and a portable radar speed gun collect data on racket acceleration, stress-strain signals, and ball speed from 15 male athletes. …”

A prospective study of the influence of the skeleton on calcium mass transfer during hemodialysis by Patricia Taschner Goldenstein (5570870)

“…</p><p>Results</p><p>Calcium mass transfer varied widely among patients in each study phase with a median of -89.5, -76.8 and -3 mmol using d[Ca] 1.25 mmol/L, -106, -26.8 and 29.7 mmol using d[Ca] 1.50 mmol/L, and 12.8, -14.5 and 38 mmol using d[Ca] 1.75 mmol/L during pre-PTX, early post-PTX and late post-PTX, respectively, which was significantly different among d[Ca] (p = 0.0001) and among phases (p = 0.040). …”

DataSheet_1_Icanbelimod (CBP-307), a next-generation Sphingosine-1-phosphate receptor modulator, in healthy men: pharmacokinetics, pharmacodynamics, safety, and tolerability in a r... by Jason Lickliter (18073228)

“…After single-dose 0.5 mg, although a high-fat breakfast versus fasting did not affect maximal decrease, lymphocyte counts tended to be lower after breakfast across most timepoints up to 72 hours. …”