Synthesis and Biological Evaluation of MEK/mTOR Multifunctional Inhibitors as Novel Anticancer Agents by Marcian E. Van Dort (21374093)

Subjects:

Adiponectin-induced Irak3 plays an important role in rosiglitazone-mediated decrease of Mcp1. by Maarten Hulsmans (181118)

The position of the mutations I989T, V992M and V997M in the ACE C domain. by Olga V. Kryukova (19819428)

Subjects:

FGFR3/fibroblast growth factor receptor 3 inhibits autophagy through decreasing the ATG12–ATG5 conjugate, leading to the delay of cartilage development in achondroplasia by Xiaofeng Wang (119575)

“…Furthermore, we found that FGFR3 interacted with ATG12–ATG5 conjugate by binding to ATG5. …”

NO donors and Bradykinin increase 26S proteasome reporter protein levels and decrease 26S proteasome activity. by Hongtao Liu (114450)

Decreased Tks5 expression results in neural crest-derived defects. by Danielle A. Murphy (212554)

“…<p>(A–B) Melanophores within the trunk region above the yolk sac extension in control MO-injected and Tks5 MO-injected embryos were qualitatively (A) and quantitatively (B) analyzed. n = 15 embryos and SEM is shown by bar. p values obtained from Student's t-test. ** denotes p<0.01. …”

Growth of N-replete and N stressed cultures. by Steve Dagenais Bellefeuille (654383)

<i>Pw1</i> deletion does not result in significant decrease in oxytocin production and release. by Anne-Lyse Denizot (3170142)

DataSheet3_Rhubarb Enema Decreases Circulating Trimethylamine N-Oxide Level and Improves Renal Fibrosis Accompanied With Gut Microbiota Change in Chronic Kidney Disease Rats.PDF by Chunlan Ji (5712218)

“…</p><p>Conclusion: Rhubarb enema decreases circulating TMAO level and improves renal fibrosis in 5/6Nx CKD rats, which may be related to the regulation of intestinal microbial community.…”

DataSheet4_Rhubarb Enema Decreases Circulating Trimethylamine N-Oxide Level and Improves Renal Fibrosis Accompanied With Gut Microbiota Change in Chronic Kidney Disease Rats.docx by Chunlan Ji (5712218)

“…</p><p>Conclusion: Rhubarb enema decreases circulating TMAO level and improves renal fibrosis in 5/6Nx CKD rats, which may be related to the regulation of intestinal microbial community.…”

DataSheet2_Rhubarb Enema Decreases Circulating Trimethylamine N-Oxide Level and Improves Renal Fibrosis Accompanied With Gut Microbiota Change in Chronic Kidney Disease Rats.PDF by Chunlan Ji (5712218)

“…</p><p>Conclusion: Rhubarb enema decreases circulating TMAO level and improves renal fibrosis in 5/6Nx CKD rats, which may be related to the regulation of intestinal microbial community.…”

DataSheet1_Rhubarb Enema Decreases Circulating Trimethylamine N-Oxide Level and Improves Renal Fibrosis Accompanied With Gut Microbiota Change in Chronic Kidney Disease Rats.PDF by Chunlan Ji (5712218)

“…</p><p>Conclusion: Rhubarb enema decreases circulating TMAO level and improves renal fibrosis in 5/6Nx CKD rats, which may be related to the regulation of intestinal microbial community.…”

FA decrease in 5STS impaired participants. by Charlotte Bernard (433013)

The decreased permeability caused by phospholipid content in the membrane could drive the emergence of other functions in the protocells. by Wentao Ma (326530)

Blocking C5L2 decreased C5a-primed neutrophils expression of membrane-bound PR3 (mPR3). by Jian Hao (160736)

Decreased proliferation and increased apoptosis in <i>Mab21l2</i> mutant embryos. by Yohei Saito (180130)

“…Scale bars represent 100 µm (A, D, H, K) and 50 µm (N and P). (R) Quantitative RT-PCR for genes regulating cell proliferation and apoptosis (<i>N-myc</i>, <i>Id2</i>, <i>Cyclin D1</i>, <i>Cyclin D2</i>), marker genes of myocardial differentiation (<i>Anf</i>, <i>Chisel</i>, <i>Mlc2v</i>), genes essential for the development of the trabecular myocardium (<i>Erbb2</i>, <i>Erbb4</i>, <i>Bmp10</i>), genes essential for heart development (<i>Nkx2.5</i>, <i>Gata4</i>), and endocardial transcripts (<i>Flk1</i>, <i>Tie1</i>, <i>Tie2</i>) normalized to <i>Gapdh</i> expression using RNA from dissected hearts of E11.5 WT and <i>Mab21l2</i> mutant (−/−) embryos. …”

H₂S is responsible for decreased active MMP-1/TIMP-1 ratio. by Ingrid Gomez (520676)

H₂S is responsible for decreased active MMP-1/TIMP-2 ratio. by Ingrid Gomez (520676)

A. We randomly selected 20 mutually exclusive groups of protein complexes that contained exactly five subunits; we mapped the corresponding gene pairs to SINaTRA scores, and plotte... by Alexandra Jacunski (5665486)

“…A SINaTRA cutoff of 0.95 has approximately half of its pairs associated with the same complex; however, a decrease in the cutoff shifts this balance. …”

DataSheet_1_Imiquimod Boosts Interferon Response, and Decreases ACE2 and Pro-Inflammatory Response of Human Bronchial Epithelium in Asthma.pdf by Juan José Nieto-Fontarigo (11800142)

“…Background<p>Both anti-viral and anti-inflammatory bronchial effects are warranted to treat viral infections in asthma. We sought to investigate if imiquimod, a TLR7 agonist, exhibits such dual actions in ex vivo cultured human bronchial epithelial cells (HBECs), targets for SARS-CoV-2 infectivity.…”