Showing 81 - 100 results of 10,256 for search '(( 50 ng decrease ) OR ((((( 50 n decrease ) OR ( 50 μ decrease ))) OR ( 5 μ decrease ))))', query time: 0.25s Refine Results
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    Discovery of 2‑Ethoxy-5-isobutyramido‑<i>N</i>‑1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects by Jie Zhou (28945)

    Published 2023
    “…In this work, a series of novel benzamide derivatives were designed and synthesized as Kv2.1 inhibitors, and extensive structure–activity relationships led to highly potent and selective Kv2.1 inhibitors having IC<sub>50</sub> values of 10<sup>–8</sup> M. Among them, compound <b>80</b> (IC<sub>50</sub> = 0.07 μM, selectivity >130 fold over other K<sup>+</sup>, Na<sup>+</sup>, and Ca<sup>2+</sup> ion channels) was able to decrease the apoptosis of HEK293/Kv2.1 cells induced by H<sub>2</sub>O<sub>2</sub>. …”
  4. 84

    Discovery of 2‑Ethoxy-5-isobutyramido‑<i>N</i>‑1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects by Jie Zhou (28945)

    Published 2023
    “…In this work, a series of novel benzamide derivatives were designed and synthesized as Kv2.1 inhibitors, and extensive structure–activity relationships led to highly potent and selective Kv2.1 inhibitors having IC<sub>50</sub> values of 10<sup>–8</sup> M. Among them, compound <b>80</b> (IC<sub>50</sub> = 0.07 μM, selectivity >130 fold over other K<sup>+</sup>, Na<sup>+</sup>, and Ca<sup>2+</sup> ion channels) was able to decrease the apoptosis of HEK293/Kv2.1 cells induced by H<sub>2</sub>O<sub>2</sub>. …”
  5. 85

    Discovery of 2‑Ethoxy-5-isobutyramido‑<i>N</i>‑1-substituted Benzamide Derivatives as Selective Kv2.1 Inhibitors with In Vivo Neuroprotective Effects by Jie Zhou (28945)

    Published 2023
    “…In this work, a series of novel benzamide derivatives were designed and synthesized as Kv2.1 inhibitors, and extensive structure–activity relationships led to highly potent and selective Kv2.1 inhibitors having IC<sub>50</sub> values of 10<sup>–8</sup> M. Among them, compound <b>80</b> (IC<sub>50</sub> = 0.07 μM, selectivity >130 fold over other K<sup>+</sup>, Na<sup>+</sup>, and Ca<sup>2+</sup> ion channels) was able to decrease the apoptosis of HEK293/Kv2.1 cells induced by H<sub>2</sub>O<sub>2</sub>. …”
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