Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor by Beatrice Noce (16540800)

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Drugs IC₅₀s data during the study period. by Winnie Okore (14139712)

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Synthesis, Biological Evaluation, Structure–Activity Relationship, and Mechanism of Action Studies of Quinoline–Metronidazole Derivatives Against Experimental Visceral Leishmaniasi... by Akanksha Upadhyay (6732857)

“…Among all synthesized derivatives, <b>15b</b> and <b>15i</b> showed significant antileishmanial efficacy against both extracellular promastigote (IC₅₀ 9.54 and 5.42 μM, respectively) and intracellular amastigote (IC₅₀ 9.81 and 3.75 μM, respectively) forms of Leishmania donovani with negligible cytotoxicity toward the host (J774 macrophages, Vero cells). …”

GTDE decreased the expression of the NLRP3 inflammasome and AGEs in the cerebral cortex. by Hui-Chuan Kuo (12368492)

<i>In vitro</i> activity of aryl-thiazole derivatives against <i>Schistosoma mansoni</i> schistosomula and adult worms by Adriana S. A. Pereira (5900249)

“…Adult worms’ treatment with 50 μM NJ05, NJ07 or NJ05 + NJ07 showed decreased motility to 30–50% compared with controls. …”

HIV care budget increase and reduction in transmissions by ART initiation strategy and CD4 count at presentation to care, both after 10 years. by Eric N. Ouattara (6890174)

Identification of Potent DNA Gyrase Inhibitors Active against Mycobacterium tuberculosis by Bongkochawan Pakamwong (12315428)

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Cost-effectiveness and budget impact of immediate antiretroviral therapy initiation for treatment of HIV infection in Côte d’Ivoire: A model-based analysis by Eric N. Ouattara (6890174)

“…<i>Immediate ART</i> increased the 5-year HIV care budget from $801.9M to $812.6M compared to <i>ART<350/μL</i>.…”

Cardiac-specific p38γ/δ^act overexpression decreases cardiac glycogen storage and lipid accumulation. by Ayelén M. Santamans (5487941)

Multi-way sensitivity analysis on transmission rate, CD4 count at diagnosis, and ART costs in a model-based analysis of Immediate ART initiation in Côte d’Ivoire. by Eric N. Ouattara (6890174)

Running decreased hippocampal amyloid burden. by Kaja Falkenhain (9317016)

Ellagic acid decreases lysosomal integrity. by Ahmad Salimi (10204515)

Ellagic acid decreases ROS formation. by Ahmad Salimi (10204515)

Ellagic acid decreases mitochondrial damages. by Ahmad Salimi (10204515)

Contact Line Ice Nucleation Is the Dominant Freezing Mechanism for Water on Macro- and Microscopic Polypropylene Surfaces by Paul Bieber (19461094)

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SNPs IC₅₀s data at codon 876 during the study period. by Winnie Okore (14139712)

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In Vitro Screening for ToxCast Chemicals Binding to Thyroxine-Binding Globulin by Stephanie A. Eytcheson (4284421)

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BCL2 antiapoptotic protein exhibits heterogeneous expression in Ba/F3 EML4-ALK^mutants. by Richard Junior Zapata Dongo (17912565)

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Modeling of Microplastics Migration in Soil and Groundwater: Insights into Dispersion and Particle Property Effects by Yaqiang Wei (11230938)

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Synthesis and Biological Evaluation of Heterocyclic Ring-Fused 20(<i>S</i>)‑Protopanaxadiol Derivatives as Potent Antiosteoporosis Agents by Shuan-Jing Wang (16854232)

“…Among these compounds, <b>33</b> (SH491, IC₅₀ = 11.8 nM) showed the highest potency with 100% inhibition at 0.1 μM and 44.4% inhibition at an even lower concentration of 0.01 μM, which was much more potent than the lead compound PPD (IC₅₀ = 10.3 μM). …”