Analysis of sphingosine levels from BAL. by Henning Carstens (13132801)

DnaK’s ATPase activity is stimulated by ribosomes and required to reduce protein synthesis. by Carissa Chan (18310140)

Subjects:

Taste sensilla in the wing and RNA-seq screen of control and <i>Poxn</i> wings. by Zhe He (508742)

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

Decreased echinocandin susceptibility in <i>Candida parapsilosis</i> causing candidemia and emergence of a pan-echinocandin resistant case in China by Yating Ning (11264310)

Cytoskeletal Drugs Modulate Off-Target Protein Folding Landscapes Inside Cells by Caitlin M. Davis (5642156)

“…The decreased compactness and folding stability of PGK could be explained by the decreased extent of crowding induced by these drugs. …”

Variable importance plot (mean decrease accuracy and mean decrease Gini). by Fernando Martinez-Taboada (8655132)

Description of the cohort (N = 118 patients). by Bastien Le Floc’h (14773916)

“…An HLA-G plasma level ≤ 50 ng/ml on day 8 after LT was significantly associated with a higher rejection risk. …”

The <i>rcan-1</i> rearrangement allele decreases expression of <i>rcan-1</i>. by Yuehui Zhao (3146229)

“…The gene with the largest and most significant expression decrease was <i>rcan-1</i>. Red: p<0.01, log₂(Fold Change) > 1. …”

Decreased trigger factor association and increased DnaK association with ribosomes furthers protein homeostasis during Mg²⁺ starvation. by Carissa Chan (18310140)

Subjects:

Relative fold change (relative to untreated control cells) of the <i>HER-2</i> gene among LS174T and IEC-18 cells. by Asadollahi Parisa (8837432)

Subjects:

Relative fold change (relative to untreated control cells) of the <i>PTGS-2</i> gene among LS174T and IEC-18 cells. by Asadollahi Parisa (8837432)

Subjects:

Prevalence and anatomic level of stenosis ≥ 50% in either limb. by O. Stivalet (6890189)

Introduction of potential genes and signal pathways related to cisplatin resistance in the A2780 cell line based on Bioinformatics analysis. by Hadi Alizadeh (20854757)

Subjects:

Western blot analysis demonstrating the expression of EGFR, HER-2 and COX-2 proteins in LS174T and IEC-18 cells. by Asadollahi Parisa (8837432)

Subjects:

Long COVID prevalence decreases with vaccine uptake, globally. by Manlio De Domenico (626037)

Subjects:

Long COVID prevalence decreases with vaccine uptake in the U.S. by Manlio De Domenico (626037)

Subjects:

Olaparib reverses the oxLDL-mediated decrease in co-immunoprecipitation of IκBα with RelA or p50. by Khamis Mustafa (17941332)

“…Relative band densities from three independent experiments were analyzed. (A) OxLDL decreased co-immunoprecipitation of IκBα with both RelA and p50, and olaparib reversed the effect of oxLDL on the dissociation of IκBα with RelA and p50. …”

Upcycling of Postconsumer Recyclate Polypropylene into Low Warping and High Toughness 3D Printable Filaments by Animesh Gopal (18521180)

“…Incorporation of poly­(butylene adipate-<i>co</i>-terephthalate) (PBAT) along with maleic anhydride grafted polypropylene (MAPP) in specific proportions led to a significant enhancement in mechanical properties, miscibility, crystallization behavior, and 3D printability. rPP/PBAT blends with 20 wt % PBAT and 10 wt % MAPP exhibited a 62-fold enhancement in elongation at break over rPP (from 1.88 to 118.29%) and a 72-fold increase in toughness (from 2 to 143.60 kJ/m³) with almost similar tensile strength. …”