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Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3
منشور في 2023"…<p></p><div> <p>Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour growth and survival. …"
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Collaborative Caching for D2D Content Sharing in 5G
منشور في 2021احصل على النص الكامل
doctoralThesis -
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Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage
منشور في 2018"…The mechanism of cell senescence delay and connection between these responses is unknown. We describe herein that the cruciferous vegetable-derived metabolite, sulforaphane (SFN), activates Nrf2 and delays senescence of human MRC-5 and BJ fibroblasts in vitro. …"
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Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications
منشور في 2019"…We aimed to investigate the susceptibility and prognostic implications of genetic variation in CCL5 signaling genes in TNBC in the present study. …"
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Neonatal Simulation Program: A 5 Years Educational Journey From Qatar
منشور في 2022"…The mean duration of the LISA catheter insertion at the beginning of the workshop was 23.5 ± 15.9 compared to 12.1 ± 8.5 s at the end of the workshop (<i>P</i> = 0.001). …"
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5G Networks Security Mitigation Model: An ANN-ISM Hybrid Approach
منشور في 2025"…<p dir="ltr">The advent of Fifth-Generation (5G) networks has introduced significant security challenges due to increased complexity and diverse use cases. …"
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Targeted Inactivation of Rin3 Increases Trabecular Bone Mass by Reducing Bone Resorption and Favouring Bone Formation
منشور في 2021"…At 52 weeks, Oc.S/BS did not differ between genotypes but single labelled perimeter (SL.Pm/B.Pm (%)) was significantly higher in Rin3<sup>−</sup>/<sup>−</sup> mice (24.4 ± 6.4 vs. 16.5 ± 3.8, p = 0.003). We conclude that Rin3 negatively regulates trabecular bone mass in mice by inhibiting osteoclastic bone resorption and favouring bone formation. …"
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Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes
منشور في 2023"…AimCardiac autonomic neuropathy (CAN) has been suggested to be associated with hypoglycemia and impaired hypoglycemia unawareness. We have assessed the relationship between CAN and extensive measures of glucose variability (GV) in patients with type 1 and type 2 diabetes. …"
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Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes
منشور في 2023"…<h3>Aim</h3><p dir="ltr">Cardiac autonomic neuropathy (CAN) has been suggested to be associated with hypoglycemia and impaired hypoglycemia unawareness. We have assessed the relationship between CAN and extensive measures of glucose variability (GV) in patients with type 1 and type 2 diabetes.…"
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Ecotoxicological Assessment of Thermally- and Hydrogen-Reduced Graphene Oxide/TiO<sub>2</sub> Photocatalytic Nanocomposites Using the Zebrafish Embryo Model
منشور في 2019"…H<sub>2</sub>RGOTi showed a NOEC similar to RGOTi. However, no significant mortality was detected at all concentrations used in the acutoxicity assay (up to1000 mg/L), thus indicating a hypothetical LC<sub>50</sub> higher than 1000 mg/L. …"
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SARS-CoV-2 Infection and Smoking: What is the association? A brief review
منشور في 2021"…Smoking has been shown to enhance the expression of the angiotensin-converting enzyme-2 (ACE-2) and transmembrane serine protease 2 (TMPRSS2) key entry genes utilized by SARS-CoV-2 to infect cells and induce a ‘cytokine storm’, which further increases the severity of COVID-19 clinical course. …"
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Neither Neoadjuvant nor Adjuvant Therapy Increases Survival After Biliary Tract Cancer Resection with Wide Negative Margins
منشور في 2012"…Immediate resection increased median survival from 42.3 to 53.5 months (p = 0.01). …"
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Coevolving residues distant from the ligand binding site are involved in GAF domain function
منشور في 2025"…<p dir="ltr">Ligand binding to GAF domains regulates the activity of associated catalytic domains in various proteins, such as the cGMP-hydrolyzing catalytic domain of phosphodiesterase 5 (PDE5) activated by cGMP binding to GAFa domain. …"
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Lifetime prevalence, risk, and treatment of mood and anxiety disorders in Qatar's national mental health study
منشور في 2024"…</p><h3>Methods</h3><p dir="ltr">We conducted a national phone survey of 5,195 Qatari and Arab residents in Qatar (2019–2022) using the Composite International Diagnostic Interview Version 3.3 and estimated lifetime mood and anxiety defined diagnoses. …"
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Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity—Opportunity for Repurposed Chemotherapy of COVID-19 Infection
منشور في 2020"…These sites were partially conserved in related coronaviridae: SARS-CoV and MERS. Finally, we identified drugs which increase cellular MG concentration to virucidal levels: antitumor drugs with historical antiviral activity, doxorubicin and paclitaxel. …"
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A genetically encoded BRET-based SARS-CoV-2 Mpro protease activity sensor
منشور في 2022"…<p dir="ltr">The main protease, M<sup>pro</sup>, is critical for SARS-CoV-2 replication and an appealing target for designing anti-SARS-CoV-2 agents. …"
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Demographics and Epidemiology of Hepatitis B in the State of Qatar: A Five-Year Surveillance-Based Incidence Study
منشور في 2019"…Here, we report on the incidence and epidemiological characteristics of hepatitis B in Qatar between 2010 and 2014.…"
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Extended Preoperative Chemotherapy Does Not Improve Pathologic Response and Increases Postoperative Liver Insufficiency After Hepatic Resection for Colorectal Liver Metastases
منشور في 2010"…Background The optimal duration, safety, and benefit of preoperative chemotherapy in patients with colorectal liver metastases (CLM) are unclear. We evaluated the association between the duration of preoperative chemotherapy with 5-fluorouracil (5-FU), leucovorin, oxaliplatin (FOLFOX) ± bevacizumab, pathologic response, and hepatotoxicity after hepatic resection for CLM. …"
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