Image 6_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an... حسب Chao Song (379006)

"…</p>Results<p>Three RCTs (IMpower150, jRCT2080224500, and ORIENT-31) comprising a total of 1529 patients were analyzed. The PIBC regimen significantly improved PFS (hazard ratio [HR]: 0.76 [0.66, 0.87], P < 0.0001), objective response rate (risk ratio [RR]: 1.36 [1.22, 1.51], P < 0.00001), and disease control rate (RR: 1.06 [1.00, 1.12], P = 0.04). …"

Propagation of the DMI signal into flanking regions in simulated data (sampled at generation 30, significance threshold: <i>X</i>(2)<−0.005 & <i>D’</i><0) when only homozygous geno... حسب Juan Li (146180)

"…The direct selection coefficients α and β were drawn from exponential distribution with mean value 0.001. The strength of epistasis was drawn from a uniform distribution, γ∈[-1, -0.001], which is represented by the blue colour intensity in panels B&C. …"

<b>Role of the Chaperone ClpB in</b><b> </b><b>Mycoplasma bovis</b><b> Virulence: Implications for </b><b>stress response, a</b><b>dhesion, </b><b>b</b><b>iofilm </b><b>d</b><b>eve... حسب Hui zhang (22187170)

"…<p dir="ltr">ClpB, an ATP-dependent molecular chaperone belonging to the Hsp100/Clp subfamily of AAA+ ATPases, plays a crucial role in protein disaggregation, thereby enhancing bacterial survival under stress conditions. …"

Minimum concentration of Amphotericin B in serum according to the formulation, dose, and daily or prolonged intermittent therapeutic regimen حسب Leticia Aparecida Schiave (8438409)

"…The geometric mean Cmin tended to decrease with a reduction in the dose and frequency of intermittent L-AmB infusions: 357 ng/mL (100 mg 4 to 5 times/week) > 263 ng/mL (50 mg 4 to 5 times/week) > 227 ng/mL (50 mg 1 to 3 times/week). …"

Table_1_Total weight loss induces the alteration in thyroid function after bariatric surgery.docx حسب Ziru Tian (17869238)

"…The mean %TWL was 28.29% after 1 year. TSH decreased from 2.33 (1.67, 3.04) uIU/mL to 1.82 (1.21, 2.50) uIU/mL (P < 0.001), FT3 decreased from 3.23 ± 0.42 pg/mL to 2.89 ± 0.41 pg/mL (P < 0.001), FT4 decreased from 1.11 ± 0.25 ng/dL to 1.02 ± 0.25 ng/dL (P < 0.001), TT3 decreased from 1.13 (1.00, 1.25) ng/mL to 0.89 (0.78, 1.00) ng/mL (P < 0.001), and TT4 decreased from 8.28 ± 1.69 ug/mL to 7.82 ± 1.68 ug/mL 1 year postoperatively (P < 0.001). …"

Supplementary Figure S1 حسب Cass Dedert (12837572)

"…Neuronal cell viability under high-glucose stress is preserved by PGRN in a GSK3β-dependent manner.</strong> Cells were treated for 72 hours with 100 mM glucose (HG), 200 ng/ml PGRN, and 10 µM SB216763 (SB) before imaging and testing. …"

Effect of AAS27 and AAS41 cocktail on expression of pro-inflammatory and anti-inflammatory cytokines by MΦ that were first activated with LPS or cocktail of r<i>Aam</i>IGFBP-rP1, r... حسب Mariam Bakshi (7962230)

"…Data are reported as mean <i>A</i>_450nm of two biological replicates ± SEM. …"

Data_Sheet_1_Quantifying Pesticide Exposure Risk for Monarch Caterpillars on Milkweeds Bordering Agricultural Land.PDF حسب Paola Olaya-Arenas (6841796)

"…For thiamethoxam, isolating milkweeds 50–100 m from the nearest corn or soybean field tended to decrease the concentration and likelihood of detecting residues, whereas landscape composition surrounding milkweed sites had comparatively weak predictive power. …"

Relationship between locomotor function and muscle tone. حسب Katsuhiro Kawakami (3015042)

"…<p>Scatter plots showing the relationship between the BBB score (y-axis) and the Ashworth score (x-axis) 6 hours after mild SCI (yellow), 30 min after intrathecal administration of 30 μg of morphine (panel a), 10 ng of DAMGO (μ-opioid receptor agonist, panel b), 100 μg of DPDPE (δ-opioid receptor agonist, panel c), and 150 μg of U50,488H (κ-opioid receptor agonist, panel d) (red) and 30 min after intrathecal administration of naloxone (opioid receptor antagonist) (blue). …"

C1 shows similar results on macrophages as for microglia and does not interfere with cell activity, proliferation, and cell death are not affected in non-stimulated conditions. حسب Philipp Jordan (9364068)

"…<b>d)</b> When stimulated with 1 μg/mL LPS (for 48 hours, using the same protocol as referred above C1 caused a dose independent decrease in cell activity for all 3 concentrations of C1 (0.025μM: 78.47 ± 31.61%, p = 0.0245; 0.25μM: 69.31 ± 36.50%, p = 0.001; 2.5μM: 66.48 ± 31.17%, p<0.001) in comparison to the positive control (100 ± 4.74%) and when cells were treated with 2.5 μM C1 there was a reduction of the cell activity also when compared to the DMSO control (p = 0.0310). …"

Image_1_Immune Protective Evaluation Elicited by DNA Vaccination With Neospora caninum Dense Granules Proteins in Mice.TIF حسب Guili Yu (10201136)

"…The immune protective efficacy revealed that pcNcGRA4, pcNcGRA14, and pcNcGRA17 DNA vaccines could individually increase the survival rate to 50, 37.5, and 25% in comparison with 0% in the control group; prolong the survival time more than 20.88 ± 11.12, 18.88 ± 10.83, and 16.63 ± 10.66 days compared with the control group of 4 ± 1.31 days; and decrease parasite burden in the brains to 297.63 ± 83.77, 471.5 ± 110.74, and 592.13 ± 102.2 parasites/100 ng comparing with 1221.36 ± 269.59 parasites/100 ng in the control group. …"

Effects of <i>Es</i>e and F3 on cell viability and inflammation markers in macrophages. حسب Josy Goldoni Lazarini (2601049)

"…<p>(A and C) Evaluation of RAW 264.7 macrophages treated with culture medium (M), LPS (10 ng/mL,-), <i>Es</i>e (10, 30, 100, 300 and 1000 μg/mL) and F3 (0.1, 10, 30, 100 and 300 μg/mL) for 24h. …"

High-Throughput Absolute mRNA Quantification Using Real-time RT-PCR حسب Anthony J Bais (13285305)

"…A reaction mix for 1 ug of amplicon cDNA contained 10 ul of 10x PCR buffer (containing 15 mM MgCl2), 2 ul of 10 mM dNTP mix, 0.5 uM of each primer, 0.5 ul of 2.5 U HotStar-Taq polymerase (Qiagen), 100 ng of cDNA template and water to 100 ul. …"

5OMV Inhibits HMGB1-Induced Tube Formation in HUVECs. حسب Wenyue Hou (10203722)

"…<p>Representative images <b>(A)</b> of the wound healing assay (captured at 0 h and 24 h post-scratching) demonstrated that co-treatment with 5OMV (100, 250, and 500 μg mL⁻¹) and HMGB1 (800 ng mL⁻¹) significantly attenuated HUVECs migration. …"

Proteolysis of VWF strings at the surface of HUVEC by recombinant ADAMTS13 variants under flow. حسب Anton Letzer (8796422)

"…Capturing of an automated time-lapse multi-picture series of 12 images every 36 sec for 12 min was started before addition of 100 ng/ml recombinant ADAMTS13 variants. Analysis was performed by merging the 12 images of each time point to one big image, a 100 μm scale bar was used to calibrate the scale in ImageJ to mm and the length of 100 strings was measured. …"

Low doses of IL-4 and IL-13 enhance cellular proliferation. حسب Quentin D’Arcy (13919516)

"…<p><b>A, B.</b> N1 and SFT1 prostate fibroblasts and HLF primary lung fibroblasts were cultured in serum-free defined media supplemented with vehicle or increasing doses (1–100 ng) of human recombinant IL-4 (<b>A</b>) or IL-13 (<b>B</b>) for 24 hours. …"

Effect of VEGF-B and imatinib on Bodipy-FA uptake into HUVECS. حسب Camiel V. J. Box (11067922)

"…<p>A: Bodipy-FA uptake in cells treated with VEGF-B 100 ng/ml and VEGF-B 300 ng/ml at different time points. …"

SufT participates in Fe-S cluster biogenesis and repair. حسب Ashutosh Tripathi (2827796)

"…<p>(A) Western blot quantification of reduced SufT protein level (green bars) and decreased aconitase (Acn) activity (brown bars) was shown in SufT-KD strain, with increasing concentration (ng/mL) of ATc (0, 50, 100, 200 and 400). …"

Effects of LPS stimulation with and without additional thrombin-driven activation of the coagulation system. حسب Doreen Tabea Spiegelburg (14419858)

"…Thrombocyte and leukocyte counts (a,b) showed no significant changes with either stimulant, except for a slight decrease of both platelets and leukocytes when stimulated with both LPS and thrombin. …"

Data_Sheet_1_Elevated concentrations of macrophage migration inhibitory factor in serum and cerebral microdialysate are associated with delayed cerebral ischemia after aneurysmal s... حسب Felix Neumaier (4391794)

"…Subgroup analyses revealed significantly higher serum levels in patients with aneurysms located in the anterior vs. posterior circulation during CP_d5−15 (17.3 [15.1–21.1] vs. 10.0 [8.4–11.5] ng/ml, p = 0.009) and in patients with DCI vs. no DCI during CP_d5−15 (17.9 [15.1–22.7] vs. 11.9 [8.9–15.9] ng/ml, p = 0.026) and LP_d16−21 (17.4 [11.7–27.9] vs. 11.3 [9.2–12.2] ng/ml, p = 0.021). …"