Table1_Coadministration of bedaquiline and pyrifazimine reduce exposure to toxic metabolite N-desmethyl bedaquiline.DOCX by Yangming Ding (8437077)

“…</p><p>Results: The in vitro f_m value indicated that the CYP3A4 pathway contributed more than 75% to BDQ metabolism to N-desmethyl-bedaquiline (M2), and TBI-166 was a moderate (IC₅₀ 2.65 µM) potential CYP3A4 inhibitor. Coadministration of BDQ and TBI-166 greatly reduced exposure to metabolite M2 (AUC_0-t 76310 vs 115704 h ng/mL, 66% of BDQ alone), whereas the exposure to BDQ and TBI-166 did not changed. …”

NMR analyses of the HPV16 E6/E6APpep and HPV16 E6/pep11** interactions. by Katia Zanier (17371)

“…Note that in the case of spectra of E6/pep11** samples some signals have lower intensity in the red spectrum than in the cyan spectrum (see enlarged view of lower panel). This decrease in signal intensity is concomitant with the appearance of a white precipitate of E6 in the NMR tube. …”

Myosin and lipid raft formation are required for the shift of ICAM-1 to the immobile fraction. by Jaap D. van Buul (5650009)

“…Experiment is done three times. Data are mean ± SEM. *p<0.05. (<b>C</b>) Cells were pretreated with 5mM methyl-β-cyclodextrin for 30 minutes (β-CD). …”

Longitudinal development of social interaction behavior after CSD stress. by M. Wendelmuth (9160278)

“…<p>(a) Experimental setup timeline for retesting. Animals of a cohort of mice were (re-)tested for SI and NORT at 7–10 days (T2), 21–24 days (T3) and 42–45 days (T4) post CSD. …”

Synthesis, Crystal Structure, EPR and DFT Studies, and Redox Properties of [2]Tetramethyldisilacobaltocenophane by Holger Braunschweig (1370640)

“…As was shown by cyclic voltammetry in THF, <b>1</b> is quasi-reversibly oxidized to the neutral cobaltocenium cation [(Me₂Si)₂(η⁵-C₅H₄)₂Co]⁺ (<b>8</b>) at a potential of <i>E</i>°_1/2 = −1.27 V (vs the Fc/Fc⁺ couple) and quasi-reversibly reduced to the corresponding anion [(Me₂Si)₂(η⁵-C₅H₄)₂Co]⁻ (<b>9</b>) at <i>E</i>°_1/2 = −2.40 V. …”

Synthesis, Crystal Structure, EPR and DFT Studies, and Redox Properties of [2]Tetramethyldisilacobaltocenophane by Holger Braunschweig (1370640)

“…As was shown by cyclic voltammetry in THF, <b>1</b> is quasi-reversibly oxidized to the neutral cobaltocenium cation [(Me₂Si)₂(η⁵-C₅H₄)₂Co]⁺ (<b>8</b>) at a potential of <i>E</i>°_1/2 = −1.27 V (vs the Fc/Fc⁺ couple) and quasi-reversibly reduced to the corresponding anion [(Me₂Si)₂(η⁵-C₅H₄)₂Co]⁻ (<b>9</b>) at <i>E</i>°_1/2 = −2.40 V. …”

PI manipulations alter sleep and activity levels. by Austin P. Dreyer (7828112)

“…<p>(A) Adult-specific dTrpA1-mediated activation of DILP+ PI cells decreases total daily sleep compared to genetic controls. …”

Changes in mitochondrial protein expression levels following ND-13 treatment. by Lior Molcho (4898791)

“…SDHAF4 protein levels increased after ND-13 treatment (A, FC = 107.4, p<0.001). Ubiquinone protein levels decreased after ND-13 treatment (B, FC = 3.5, p<0.01). …”

Delineation of sequences required for translation of uncapped VRV transcripts in region 3 of the 3’ UTR. by Dinesh Babu Paudel (10579039)

“…Numbers in parentheses indicate the region of the ToRSV-Rasp1 RNA2 3’ UTR included in the construct (WT and Δ124) or the regions that were deleted from constructs Δ3 and Δ3a to Δ3d (numbering from the 5’ end of RNA2). …”

Generating human striatal organoids. by Xinyu Chen (47670)

“…Quantifying the expression levels of PAX6 and SATB2 in sections after 45 days in culture. Organoids, <i>n</i> = 5. Data, mean ± SD. Student <i>t</i> test. *, <i>P</i> < 0.05. …”

Data_Sheet_1_Impaired Cognitive Function and Altered Hippocampal Synaptic Plasticity in Mice Lacking Dermatan Sulfotransferase Chst14/D4st1.doc by Qifa Li (747681)

“…It has been proposed that these PGs exert their function through specific interaction of CS/DS chains with its binding partners in a manner that depends on the sulfation patterns of CS/DS. …”

Phytol Suppresses Established Arthritis by Malin Hultqvist (75086)

“…Lines represent mean values.</p> <p>(C) Phytol decreases arthritis severity in the chronic phase of arthritis. …”

S1 Fig - by Jérémie Le Pen (18551533)

“…However, it appears that (i) IFITM2 restricts WT SARS-CoV-2 endosomal entry [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002767#pbio.3002767.ref122" target="_blank">122</a>], (ii) recent SARS-CoV-2 variants may evade IFITM2 [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002767#pbio.3002767.ref199" target="_blank">199</a>], and (iii) IFITM3 KO mice are hypersusceptible to WT SARS-CoV-2 [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002767#pbio.3002767.ref206" target="_blank">206</a>]. …”

Psychiatric evaluation and personality in psoriasis patients by Hacer Akgül Ceyhun (22747079)

“…In psoriasis patients with a psychiatric diagnosis, Plasticity, and Openness to experience personality traits scores showed a significant decrease with a medium effect size. …”

GJ inhibition is the key driver of single-cell Ca²⁺ spike activity. by Dharsan K. Soundarrajan (11632145)

“…<b>(B-E)</b> <i>K</i>_<i>PLC</i> is increased left-to-right (red bar), and gap junction communication is decreased left-to-right (blue bar). An increase in <i>K</i>_<i>PLC</i> results in a decrease in frequency, while decrease in gap junction communication results in single-cell Ca²⁺ spikes (red arrows).…”

Land-use changes affect the functional structure of stream fish assemblages in the Brazilian Savanna by Ludmilla R. P. Alvarenga (12682514)

Endovascular revascularization of TASC C and D femoropopliteal occlusive disease using carbon dioxide as contrast by Cynthia de Almeida Mendes (10407739)

Distribution of differences of DNA methylation between normal mammary glands and mammary carcinomas. by Masaru Takabatake (3202710)

“…The curve shows a simulated normal distribution (mean = 0, standard deviation = 2.5) with the same spread as the data, but centered on zero to indicate the null hypothesis of no global trend. …”

NPB304 affected P-gp function and increased paclitaxel accumulation in P-gp-overexpressing resistant cells and tumor tissue. by Mei Mei (610571)

“…The data represent the mean ± SD. *p<0.05, **p<0.01. (C) NPB304 treatment promoted bidirectional permeability but decreased the efflux ratio of paclitaxel in a Caco-2 monolayer model. …”

Passive listening and go/No-go tasks feature comparable electrophysiological responses. by Sarah H. McGill (22505225)

“…<p>The differences between the mean peristimulus spectrograms of maximum-intensity auditory stimulus trials (65.7 dB) and no-stimulus trials (63.5 dB white noise only) are shown here for passive listening (left) and go/no-go (right tasks). …”