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decrease » decreased (Expand Search), increase (Expand Search)
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …”
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Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle
Published 2023“…We found both young and aged HSA-mUCP1 mice had decreased advanced glycation endproducts (AGEs) formed from MG, lysine-derived Nε(1-carboxyethyl)lysine (CEL) and arginine-derived hydroimidazolone, MG-H1, whereas protein glycation by glucose forming Nε-fructosyl-lysine (FL) was increased ca. 2-fold, compared to wildtype controls. …”
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Decreased Interfacial Dynamics Caused by the N501Y Mutation in the SARS-CoV-2 S1 Spike:ACE2 Complex
Published 2022“…Additionally, we find that the N501Y mutant S1-RBD displays altered dynamics that likely aids in its enhanced interaction with ACE2. …”
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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Among the affected signaling networks were TGFβ1, SPP1, and ERK regulatory networks. Conclusions. …”
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Effect of Mg incorporation on the properties of PCL/Mg composites for potential tissue engineering applications
Published 2024“…We synthesized a series of PCL/Mg composites with varying Mg concentrations and characterized their mechanical, thermal, and degradation properties. …”
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Solar hydrogen production via thermochemical magnesium oxide – Magnesium sulfate water splitting cycle
Published 2020“…<p dir="ltr">This investigation reports the thermodynamic scrutiny of the MgO/MgSO<sub>4</sub> water-splitting cycle. At the initial stage, the thermal reduction temperature required for the commencement of the thermal dissociation of MgSO<sub>4</sub> (in the absence of inert Ar) and the maximum temperature below which the water-splitting reaction is feasible is identified by performing thermodynamic equilibrium calculations. …”
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LDL-C Targets in Secondary Prevention: How Low Should We Go?
Published 2019“…<h3>Abstract</h3><p dir="ltr">The benefits of lowering low-density lipoprotein cholesterol (LDL-C), mainly using high-intensity statin therapy, and its impact on decreasing the recurrence of atherosclerotic cardiovascular disease (ASCVD) in secondary prevention has been well established. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…However, questions related to its mechanism of interaction with the substrate, furimazine, as well as bioluminescence activity remain elusive. Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Impact of trace noble metals on the catalytic performance of LaNiMgO towards methane dry reforming
Published 2024“…In durability measurements, and after 140h LaNiMgO-Rh exhibited slight decay in the CO<sub>2</sub> conversion from 77.6 % to 70.5%, the CH<sub>4</sub> conversion decreased from 72.3% to 64.2%. …”
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STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration
Published 2023“…SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. …”
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Performance evaluation of 3D-printed PLA composites doped with WE43 magnesium alloy for bone tissue engineering applications
Published 2025“…Adding WE43 alloy to PLA decreased the average pore sizes of the composites. …”
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10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes
Published 2020“…<h3>Aim</h3><p dir="ltr">The aim of this study was to evaluate the 10-day initiation protocol for MiniMed 670G hybrid closed-loop (HCL) system in individuals with type 1 diabetes on multiple daily injection (MDI) in achieving desirable glycemic control.…”
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Oxidative stress cytotoxicity induced by platinum-doped magnesia nanoparticles in cancer cells
Published 2021“…Pt/MgO nanoparticles also induced production of reactive oxygen species, decreased cellular glutathione level, and increased lipid peroxidation. …”
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Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response
Published 2019“…<p dir="ltr">Circulating proteins hold a potential benefit as biomarkers for precision medicine. Previously, we showed that systemic levels of neuropilin-1 (NRP-1) and its associated molecules correlated with poor-prognosis breast cancer. …”
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Stress granules counteract senescence by sequestration of PAI‐1
Published 2018“…SG‐mediated inhibition of senescence is associated with the recruitment of the plasminogen activator inhibitor‐1 (PAI‐1), a known promoter of senescence, to these entities. …”