بدائل البحث:
nn decrease » _ decrease (توسيع البحث), a decrease (توسيع البحث), mean decrease (توسيع البحث)
ng decrease » _ decrease (توسيع البحث), a decrease (توسيع البحث), we decrease (توسيع البحث)
nm decrease » _ decrease (توسيع البحث), a decrease (توسيع البحث), we decrease (توسيع البحث)
n decrease » _ decrease (توسيع البحث), a decrease (توسيع البحث), _ decreased (توسيع البحث)
50 nn » 50 ns (توسيع البحث), 59 nn (توسيع البحث)
50 ng » 50 mg (توسيع البحث), 10 ng (توسيع البحث), 5 ng (توسيع البحث)
10 nm » 100 nm (توسيع البحث), 10 mm (توسيع البحث)
50 n » 50 ns (توسيع البحث), 50 μ (توسيع البحث), 50 _ (توسيع البحث)
nn decrease » _ decrease (توسيع البحث), a decrease (توسيع البحث), mean decrease (توسيع البحث)
ng decrease » _ decrease (توسيع البحث), a decrease (توسيع البحث), we decrease (توسيع البحث)
nm decrease » _ decrease (توسيع البحث), a decrease (توسيع البحث), we decrease (توسيع البحث)
n decrease » _ decrease (توسيع البحث), a decrease (توسيع البحث), _ decreased (توسيع البحث)
50 nn » 50 ns (توسيع البحث), 59 nn (توسيع البحث)
50 ng » 50 mg (توسيع البحث), 10 ng (توسيع البحث), 5 ng (توسيع البحث)
10 nm » 100 nm (توسيع البحث), 10 mm (توسيع البحث)
50 n » 50 ns (توسيع البحث), 50 μ (توسيع البحث), 50 _ (توسيع البحث)
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3‑Hydroxyquinolin-2-Ones Act as Dual Inhibitors of Ferroptosis and Monoamine Oxidase B: Reducing Alzheimer’s Disease-Related Amyloid Precursor Protein and Hyperphosphorylated Tau I...
منشور في 2025"…Compound <b>21d</b> emerged as a promising candidate, exhibiting potent and selective MAO-B inhibitory activity (IC<sub>50</sub> = 87.47 nM, SI > 229), as well as excellent antiferroptosis activity through modulation of the iron metabolic pathway and GSH-GPX4 axis in vitro<i>.…"
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Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes
منشور في 2022"…Here, we discovered a novel, potent, and selective MST1 inhibitor <b>19</b> (IC<sub>50</sub> = 23 nM), which inhibited the phosphorylation of MST1-protected β cells from the damage of inflammatory cytokines in vitro. …"
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Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes
منشور في 2022"…Here, we discovered a novel, potent, and selective MST1 inhibitor <b>19</b> (IC<sub>50</sub> = 23 nM), which inhibited the phosphorylation of MST1-protected β cells from the damage of inflammatory cytokines in vitro. …"
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170
Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance...
منشور في 2021"…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo[1,5-<i>a</i>]pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"
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Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance...
منشور في 2021"…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo[1,5-<i>a</i>]pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC<sub>50</sub> = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …"
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High resolution structures visible with the 25 nm zone plate objective.
منشور في 2022"…<p>139 CryoSXT tomograms were recorded from 107 cells using a 25 nm zone plate objective and several structures that were unrelated to HSV-1 infection were observed, including some that were not visible using the 40 nm zone plate objective. …"
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