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Notch Signaling Inhibition by LY411575 Attenuates Osteoblast Differentiation and Decreased Ectopic Bone Formation Capacity of Human Skeletal (Mesenchymal) Stem Cells
Published 2019“…Hematoxylin and eosin staining and Sirius red staining were performed to identify bone formation in vivo. Results. Among the tested molecules, LY411575, a potent γ-secretase and Notch signaling inhibitor, exhibited significant inhibitory effects on osteoblastic differentiation of hBMSCs manifested by reduced ALP activity, mineralized matrix formation, and decreased osteoblast-specific gene expression as well as in vivo ectopic bone formation. …”
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A Case Study to Identify the Hindrances to Widespread Adoption of Electric Vehicles in Qatar
Published 2020“…<p dir="ltr">The adoption of electric vehicles (EVs) have proven to be a crucial factor to decreasing the emission of greenhouse gases (GHG) into the atmosphere. …”
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A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity
Published 2024“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”
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Light chain amyloidosis presenting with autoimmune hepatitis-primary sclerosing cholangitis overlap syndrome
Published 2020“…We present a rare case of a 46-years-old female with systemic amyloidosis secondary to AL amyloidosis manifesting primarily as nephrotic syndrome and AIH-PSC overlap syndrome.…”
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Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex
Published 2022“…<p dir="ltr">Corrigendum: Decreased interfacial dynamics caused by the N501Y mutation in the SARS-CoV-2 S1 spike:ACE2 complex: Frontiers in Molecular Biosciences <a href="https://dx.doi.org/10.3389/fmolb.2022.846996" target="_blank">https://dx.doi.org/10.3389/fmolb.2022.846996</a>, published online 22 July 2022.…”
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High-sensitive detection and quantitation of thyroid-stimulating hormone (TSH) from capillary/fingerstick and venepuncture whole-blood using fluorescence-based rapid lateral flow i...
Published 2023“…BackgroundIn the last decade, point of care testing (POCT) such as lateral flow immunoassays (LFIA) were developed for rapid TSH measurement. …”
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Accelerating Care: Enhancing Patient Satisfaction through a Quality Initiative in the Obstetrics and Gynaecology Emergency Department at Al Wakra Hospital, Qatar
Published 2023“…The proportion of patients spending less than 8 hours in the OB ED observation beds rose from 74% in January 2022 to over 98% in 2023. Notably, there was a remarkable decrease in patients who Left Without Being Seen (LWBS) and in absconded patient rates from 2020 to 2023 (Figure 2).…”
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Geomorphological changes in the coastal area of Farasan Al-Kabir Island (Saudi Arabia) since mid Holocene based on a multi-proxy approach
Published 2018“…The geomorphological evolution of the southeastern coastal area of Farasan Al-Kabir Island (Saudi Arabia) is revealed by the mapping of modern landforms and a multi-proxy and high spatial resolution study including grain size, particulate organic carbon, mineralogy, element geochemistry, benthic foraminifera analysis and radiocarbon dating of a 3.3-m long sediment core. …”
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Effect of the stretch rate during uniaxial testing on the mechanical properties of prolene
Published 2017“…Of the mechanical properties of special significance are the following three properties: peak load (N), extension (%) at peak load, and linear stiffness (N/mm). Uniaxial tensile testing was performed on mesh samples on a universal testing machine and involved loading different samples at 5 cross-head speeds of: 1, 10, 50, 100, and 500 mm/min. …”
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Underrepresentation of racial and ethnic minorities in cascade testing for hereditary cancer syndromes
Published 2023“…Cascade testing is critical as relatives found to carry a pathogenic gene variant have the opportunity to pursue targeted cancer risk reduction and early detection, decreasing cancer-associated morbidity and mortality. …”
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Adopting Geophysical Testing Techniques in Geotechnical Investigation and Shallow Foundation Design
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