DataSheet1_Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer... by Mohamed S. Nafie (9754305)

“…<p>Cancer represents a global challenge, and the pursuit of developing new cancer treatments that are potent, safe, less prone to drug resistance, and associated with fewer side effects poses a significant challenge in cancer research and drug discovery. …”

Fig 4 - by Laure Bridoux (481118)

“…The highest HOX dose corresponds to 100%; HOXA2 (red) is translated at progressively decreasing levels, either alone, or co-translated with progressively increasing levels of HOXA3 (green) (e.g. 75% HOXA2; 75% HOXA2 + 25% HOXA3; 50% HOXA2; 50%HOXA2 + 50% HOXA3; 50% HOXA3 as indicated below the gel). …”

Table_1_Practical Model to Optimize the Strategy of Adjuvant Postmastectomy Radiotherapy in T1-2N1 Breast Cancer With Modern Systemic Therapy.docx by Fei-Fei Xu (538090)

“…After a median follow-up of 69 months, the 5-year rate of DFS, BCSS, and LRR in the overall cohort was 90.2%, 97.4%, and 3.6%, respectively. …”

Defective eviction of nucleosomes surrounding 5’ Gcn4 motifs in SWI/SNF and RSC mutants. by Yashpal Rawal (606804)

“…<b>(C-E)</b> Notched box plots for the 3 sets of 5’ sites defined in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1010277#pgen.1010277.g002" target="_blank">Fig 2A and 2B</a> and indicated again in (B), depicting (C) H3 occupancies per base pair in the ±100 bp windows surrounding the Gcn4 motifs, (D) log₂ Gcn4 occupancies taken from <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1010277#pgen.1010277.g002" target="_blank">Fig 2C</a>, and (E) log₂ Rpb3 occupancies averaged over the CDS of genes with 5’ sites. …”

Table 1_Vitamin D3 promotes white fat beige through IL-27/P38MAPK/PGC-1α pathway.docx by Yanqiu Zhou (2172931)

“…After VD₃ intervention, TC, TG, and the number of LDs were significantly reduced in both HFD rats and 3T3-L1 cells, and serum IL-6 and MCP-1 in HFD rats were decreased. Meanwhile, there was a significant increase in mRNA and protein expression for VDR, IL-27R, P38MAPK, and PGC-1α. …”

JAK/STAT signaling promotes high global translation rates in CySCs. by Ruoxu Wang (9312306)

“…Asterisks mark the hub. (C, C′) A wild-type testis showing highest OPP in CySCs adjacent to the hub and decreasing OPP levels with increasing distance from the hub. …”

Table 5_Clinical effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruct... by Quan Sun (175631)

“…Objective<p>To explore the effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruction technology.</p>Methods<p>A total of 100 patients with spinal degenerative diseases treated with unilateral biportal endoscopy during 2023–2024 in Orthopedics Center of our hospital were selected as research objects. …”

Table 8_Clinical effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruct... by Quan Sun (175631)

“…Objective<p>To explore the effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruction technology.</p>Methods<p>A total of 100 patients with spinal degenerative diseases treated with unilateral biportal endoscopy during 2023–2024 in Orthopedics Center of our hospital were selected as research objects. …”

Table 4_Clinical effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruct... by Quan Sun (175631)

“…Objective<p>To explore the effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruction technology.</p>Methods<p>A total of 100 patients with spinal degenerative diseases treated with unilateral biportal endoscopy during 2023–2024 in Orthopedics Center of our hospital were selected as research objects. …”

Table 3_Clinical effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruct... by Quan Sun (175631)

“…Objective<p>To explore the effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruction technology.</p>Methods<p>A total of 100 patients with spinal degenerative diseases treated with unilateral biportal endoscopy during 2023–2024 in Orthopedics Center of our hospital were selected as research objects. …”

Table 6_Clinical effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruct... by Quan Sun (175631)

“…Objective<p>To explore the effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruction technology.</p>Methods<p>A total of 100 patients with spinal degenerative diseases treated with unilateral biportal endoscopy during 2023–2024 in Orthopedics Center of our hospital were selected as research objects. …”

Table 7_Clinical effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruct... by Quan Sun (175631)

“…Objective<p>To explore the effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruction technology.</p>Methods<p>A total of 100 patients with spinal degenerative diseases treated with unilateral biportal endoscopy during 2023–2024 in Orthopedics Center of our hospital were selected as research objects. …”

Table 1_Clinical effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruct... by Quan Sun (175631)

“…Objective<p>To explore the effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruction technology.</p>Methods<p>A total of 100 patients with spinal degenerative diseases treated with unilateral biportal endoscopy during 2023–2024 in Orthopedics Center of our hospital were selected as research objects. …”

Table 2_Clinical effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruct... by Quan Sun (175631)

“…Objective<p>To explore the effect of unilateral biportal minimally invasive surgery in the treatment of patients with spinal degenerative diseases based on intelligent multimodal reconstruction technology.</p>Methods<p>A total of 100 patients with spinal degenerative diseases treated with unilateral biportal endoscopy during 2023–2024 in Orthopedics Center of our hospital were selected as research objects. …”

Loss of MLL1 in adult mice. by Neha Goveas (11790822)

“…<p>(A) Giemsa-stained sections from the femur of <i>Mll1</i>^{<i>FC/+; RC/+</i>} and <i>Mll1</i>^{<i>FC/FC; RC/+</i>} mice. …”

Hsp90 is required for the stability of stress granule and P-body proteins. by Teresa R. O’Meara (720286)

“…AP-MS was performed on <i>HSP90</i>^<i>E36A</i><i>-GFP/HSP90</i> cells grown at 30°C in the presence or absence of 8 μg/mL fluconazole (Flu) or 100 nM caspofungin (Casp). …”

Supplementary materials: US cost–effectiveness analysis of apixaban compared with warfarin, dabigatran and rivaroxaban for nonvalvular atrial fibrillation, focusing on equal value... by Nipun Atreja (20352417)

“…Cost–effectiveness was assessed based on a willingness-to-pay threshold of $100,000 per evLY gained (evLYG) or HYT gained (HYTG). …”

SRMS accelerates ubiquitination of FKBP51 under nutrient-replete condition. by Jung Mi Park (5204840)

“…<p>(<b>A</b>) SRMS promotes accumulation of cytosolic p-AKT(S473) in a kinase-dependent manner. …”

Pyrimidine synthesis and transport is very sensitive to mis-regulation. by Indu Warrier (581139)

“…<b>(E)</b> Adding additional uracil to the medium (from 20 ug/mL to 100 ug/mL) does not alter the uracil independent growth defect observed for SP_0701_mOFF (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1011188#pgen.1011188.s003" target="_blank">S3 Table</a>). …”

Image_1_Effects of 1,25-Dihydroxyvitamin D3 and 25-Hydroxyvitamin D3 on PBMCs From Dairy Cattle Naturally Infected With Mycobacterium avium subsp. paratuberculosis.pdf by Taylor L. T. Wherry (10022300)

“…Briefly, PBMCs were isolated and cultured in vitro with 4 ng/ml 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] or 100 ng/ml 25(OH)D₃. Treatment with 1,25(OH)₂D₃ resulted in decreased secretion for some pro-inflammatory cytokines in clinical animals, including IL-1β, IL-6, and IFN-γ. …”