Harnessing the potential of CAR-T cell therapy: progress, challenges, and future directions in hematological and solid tumor treatments by Gunjan Dagar (9339276)

“…Despite success in blood cancers, CAR-T technology faces challenges in solid tumors, including lack of reliable tumor-associated antigens, hypoxic cores, immunosuppressive tumor environments, enhanced reactive oxygen species, and decreased T-cell infiltration. …”

Shared Clean Mobility Operations for First-Mile and Last-Mile Public Transit Connections: A Case Study of Doha, Qatar by Afnan Fayez Eliyan (19517221)

“…A previous research mainly focused on car-sharing services as a self-standing mode of transportation. …”

A slow but steady nanoLuc: R162A mutation results in a decreased, but stable, nanoLuc activity by Wesam S. Ahmed (10170053)

“…Here, we combined molecular dynamics (MD) simulation and mutational analysis to show that the R162A mutation results in a decreased but stable <u>bioluminescence </u>activity of NLuc in living cells and in vitro. …”

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... by Vijay Ganji (8710491)

BRET-based biosensors for SARS-CoV-2 oligonucleotide detection by Asfia Sultana (19170880)

“…Specifically, we designed BioODs against the SARS-CoV-2 parental (Wuhan strain) and B.1.617.2 Delta variant through the conjugation of specific, fluorescently modified molecular beacons (sensor module) through a complementary oligonucleotide handle DNA functionalized with the NanoLuc (NLuc) luciferase protein such that the dissolution of the molecular beacon loop upon the binding of the viral oligonucleotide will result in a decrease in BRET efficiency and, thus, a change in the bioluminescence spectra. …”

A robust experimental-based artificial neural network approach for photovoltaic maximum power point identification considering electrical, thermal and meteorological impact by Samer Gowid (15955152)

“…The results showed a decrease in the MSE of V_mp by 74.3% (from 1.6 V to 0.411 V), and in the MSE of I_mp by 95% (from 4.4e−6 A to 2.16e−7 A), respectively. …”

Effect of Hypoxia on Maximal Fat Oxidation Rate During Incremental Cycling : Relationship to the Gas Exchange Threshold by Youmna Elsayed Hassanein (21547490)

“…The aim of this study was to evaluate MFO in normoxia (NORM) and hypoxia (HYPO) during exercise at intensities matched relative to the respiratory compensation point (RCP).</p><h3>Methods</h3><p dir="ltr">Seventeen recreationally active adults (5 females/12 males; age: 36.2 ± 7.4 year; body mass: 76.6 ± 13.1 kg) performed a ramp and a step incremental test, in NORM (The fraction of inspired oxygen; FiO₂ ≈ 21%) and HYPO (FiO₂ ≈ 13.5%), on separate days. …”

Anabolic steroids-induced delirium by Mohamed Adil Shah Khoodoruth (14589828)

“…Psychiatric aspects are of particular importance and include psychosis, delirium, mania, depression, and aggression. We describe the case of a young gentleman who was managed as a case of androgenic steroid induced delirium.…”

Old subjects with sepsis in the emergency department: trend analysis of case fatality rate by Andrea Fabbri (356760)

“…We aimed to assess the case fatality rate (CFR) and its predictors in subjects with sepsis admitted to a general Italian hospital from 2009 to 2016, stratified by risk score.…”

Sleeve Gastrectomy in Patients with Type 2 Diabetes: Anthropometric and Cardiometabolic Improvements at 1, 3, 5, 7, and 9 years—Are the Initial Benefits Sustained? by Wahiba Elhag (5245547)

“…Fasting blood glucose decreased significantly across the five time points, from 9.27 ± 4.11preop to 7.06 ± 2.70 _year9mmol/L. …”

A dramatized method for teaching undergraduate students responsible research conduct by Kuei-Chiu Chen (14108854)

Non-diabetic ketoacidosis secondary to primary hyperthyroidism by Abdulrahman F. Al-Mashdali (17148316)

“…To the best of our knowledge, our case is the third report of NDKA related to thyrotoxicosis.…”

A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate by Geethakumari, Anupriya M

“…We envisage that the NB2E3 nanobody-2× Mpro biosensor engineered here will be useful in drug discovery and functional characterization of Mpro mutants in newly emerging SARS-CoV-2 variants as well as in detecting SARS-CoV-2 infection in a point-of-care testing (POCT) format.…”
Get full text
Get full text
Get full text

Light chain amyloidosis presenting with autoimmune hepatitis-primary sclerosing cholangitis overlap syndrome by Hammad Shabir Chaudhry (20376378)

“…Primary biliary cirrhosis or primary sclerosing cholangitis (PSC) with autoimmune hepatitis (AIH) overlap syndrome is a very unusual presentation of systemic amyloidosis and to the best of our knowledge, not reported before. We present a rare case of a 46-years-old female with systemic amyloidosis secondary to AL amyloidosis manifesting primarily as nephrotic syndrome and AIH-PSC overlap syndrome.…”

Providing Health Care in Armed Conflict Countries: The Case of Yemen by Esraa Ali Sayed Ali (20741327)

Nonlinear Control of Brushless Dual-Fed Induction Generator With a Flywheel Energy Storage System for Improved System Performance by Mohammed Hamidat (3722086)

“…After optimization, the SMC settling time was significantly reduced from 0.7 seconds to 19.97 milliseconds, achieving a 96.9% improvement in response speed, while its steady-state error decreased from 0.48 to 0.06, marking an 87.5% reduction in tracking error. …”

Predictors of mortality and morbidity in critically ill COVID‐19 patients: An experience from a low mortality country by Mohamad Y. Khatib (11659459)

“…<h3>Background and Aims</h3><p dir="ltr">Clinical characteristics and factors associated with mortality in patients admitted to the intensive care unit (ICU) in countries with low case fatality rates (CFR) are unknown. We sought to determine these in a large cohort of critically ill COVID-19 patients in Qatar and explore the early mortality predictors. …”

Hypertension as an Unusual Cause of Proliferative Retinopathy: Case Report and Literature Review by Rami Hasan Saleem Abu Sbeit (16444658)

“…<p>Malignant hypertensive retinopathy is associated with characteristic fundus findings that typically do not include proliferative retinal vascular changes. We present the case of a 34-year-old patient who had bilateral decreased vision and was found to have malignant hypertension with hypertensive retinopathy changes along with unforeseen bilateral neovascularization and vitreous hemorrhage. …”

Influence of temperature on tire-pavement noise in hot climates: Qatar case by Okan, Sirin

Get full text
Get full text
Get full text

Influence of temperature on tire-pavement noise in hot climates: Qatar case by Okan Sirin (14603304)

“…There is an apparent trend of decreasing temperature coefficient with increasing mean texture depth of dense graded asphalt pavements. …”