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Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent
Published 2019“…In this study, we assess arginine auxotrophy in ovarian cancer cells and attempt to target them using arginine deprivation induced by a pegylated recombinant human Arginase I cobalt [HuArgI (Co)-PEG5000]. Ovarian cancer cells were sensitive to [HuArgI (Co)-PEG5000]-induced arginine deprivation with IC50 values in the low pM range. …”
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Characterisation of Pga1, a putative Candida albicans cell wall protein necessary for proper adhesion and biofilm formation
Published 2015“…Many of these factors are glycosylphosphatidylinositol-anchored cell surface antigenic determinant proteins. Pga1 is one such protein shown to be upregulated during cell wall regeneration. …”
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Targeting arginine auxotrophy in pancreatic cancer cells using human recombinant arginase I-induced arginine deprivation. (c2017)
Published 2017“…Sensitivity to arginine depletion using HuArgI (Co)-PEG5000 was evident in all of the tested PC cell lines with IC50 values in the pM range at 72 hours following treatment. …”
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Sleeve Gastrectomy in Patients with Type 2 Diabetes: Anthropometric and Cardiometabolic Improvements at 1, 3, 5, 7, and 9 years—Are the Initial Benefits Sustained?
Published 2025“…Mean HbA1c significantly decreased from 8.1%preop to 6.77%<sub>year 9</sub>. …”
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10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes
Published 2020“…The participants used the sensor for a median of 92% of the time and spent a median of 89% in Auto Mode. The mean HbA1c decreased from 8.2 ± 1.4% (66 ± 15.3 mmol/mol) at baseline to 6.7 ± 0.5% (50 ± 5.5 mmol/mol) at the end of the study (p = 0.017). …”
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Angiotensin II AT1 receptor internalization, translocation and de novo synthesis modulate cytosolic and nuclear calcium in human vascular smooth muscle cells
Published 2003“…Overexpression of hAT1R and hAT1R GFP decreased both basal cytosolic and nuclear Ca2+. …”
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Comparing WZB117-liposome Synthesis via Thin-film Hydration and Microfluidic Methods
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Salvia officinalis water extract: a potential hypolipidemic, hypoglycemic and anti-ulcerogenic remedy
Published 2010“…., Lamiaceae), widely used in folk medicine [1], is one of the medicinal herbs commonly used in the Middle East. …”
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β-2-himachalen-6-ol
Published 2016“…In this study, we report the isolation and identification of the major compound responsible for the anti-cancer activity of DCOE along with the mechanism of action involved. GC–MS and NMR spectroscopy revealed the identity of the major compound as β-2-himachalen-6-ol, a novel sesquiterpene unique to the Lebanese wild carrot. β-2-Himachalen-6-ol demonstrated potent anti-cancer activity against B16F-10, Caco-2, MB-MDA-231, A549 and SF-268 cancer cells (IC50 13–4 µg/ml; 58–18 µM), with SF-268 cells being the most sensitive. …”
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Proteome analysis of Candida albicans cell wall mutants. (c2011)
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Antioxidant and hepatoprotective activities of the oil fractions from wild carrot (Daucus carota ssp. carota)
Published 2015“…The sesquiterpene-rich fraction F1 had the highest FIC ability (IC50 = 0.28 mg/ml). …”
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Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer
Published 2017“…Methods Wild carrot oil extract was chromatographed to yield four fractions (F1, 100% pentane; F2, 50:50 pentane:diethyl ether; F3, 100% diethyl ether; F4 93:7 chloroform:methanol). …”
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Efficacy of Cannabidiol Combination with Cisplatin or Paclitaxel against Platinum-Resistant Ovarian Cancer Cell Lines
Published 2022“…The IC50 of cisplatin against OVCAR-3 and SK-OV-3 cell lines (1.1 and 3.3 μg/ml, respectively), and that of paclitaxel against SK-OV-3 cell line (9.9 μg/ml) were obtained as well. …”
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Effect of the stretch rate during uniaxial testing on the mechanical properties of prolene
Published 2017“…Uniaxial tensile testing was performed on mesh samples on a universal testing machine and involved loading different samples at 5 cross-head speeds of: 1, 10, 50, 100, and 500 mm/min. The corresponding properties were measured under these 5 conditions. …”
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Aortic valve function post-replacement of severe aortic stenosis by transcatheter procedure versus surgery: a systematic review and metanalysis
Published 2021“…TAVR was associated with 37% (95% CI [0.51–0.78) mean RR reduction of post-procedural PPM, a decrease that was not affected by the surgical risk at inclusion, neither by the transcatheter heart valve system. …”
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