PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications by Pramod Darvin (153341)

“…The active demethylation of PD-L1 promoter was confirmed by the increase in the distribution of 5hmC and decrease in 5mC levels and the upregulation of TET3 and downregulation of DNMTs enzymes in MCF-7 tumorspheres, compared with the cell line. …”

Modulation of SLFN11 induces changes in DNA Damage response in breast cancer by Christophe Michel Raynaud (17449906)

“…As oncogenic transcriptomic downregulation is often driven by methylation of the promotor region, we explore the demethylation effect of 5-aza-2′-deoxycytidine (decitabine), on the SLFN11 gene. …”

Screening the growth inhibition mechanism of sulfate reducing bacteria by chitosan/lignosulfonate nanocomposite (CS@LS) in seawater media by Kashif Rasool (2542492)

“…The SRBs spiked with 500 µg/mL CS@LS showed a reduction in cell viability to 1.5 × 106 MPN/mL. To assess the biosafety of the nanocomposite on the marine biota, the 72-hours acute toxicity assays using zebrafish embryo model revealed that the LC50 for the CS@LS was 103.3 µg/mL. …”

Interleukin-35 and Thymoquinone nanoparticle-based intervention for liver protection against paracetamol-induced liver injury in rats by Maisa Siddiq Abduh (16381125)

“…Additionally, IL-35 or THYO decreased TNF-α, NF-κB, IL-10, IL-6 and IFN-γ in contrast to the PAR control group. …”

Nonlinear effects in locally resonant nanostrip phononic metasurface at GHz frequencies by Feng Gao (3548)

“…<p dir="ltr">In this paper, we report on the observation of nonlinear effects in a nanostrip phononic metasurface (NPM) that enable the tuning of resonance frequencies at 1.42 GHz. …”

The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polyc... by Thozhukat Sathyapalan (704787)

“…</p><h3>Results</h3><p dir="ltr">There was significant reduction in ASP (156.7 ± 16.2 vs. 124.4 ± 14.8 ng/ml p <0.01), IL-6 (1.48 ± 0.29 vs.0.73 ± 0.34 pg/ml p = 0.01) and MCP-1 (30.4 ± 4.2 vs. 23.0 ± 4.5 pg/ml p = 0.02) after 12 weeks of atorvastatin that was maintained subsequently with 12 weeks treatment with metformin. …”

Wales’ tourists not a burden for local healthcare by Nature Research (16552612)

“…<p>Researchers in southern Wales reviewed nine-years-worth of hospital data and found non-Welsh residents accounted for only 0.5% of unintentional injuries presenting to an emergency department.…”

Low-Dose Eltrombopag in a Patient with Chronic Idiopathic Thrombocytopenic Purpura Post Sleeve Gastrectomy by Mohanad A. Ahmed (14777299)

“…Here we are reporting a 46-year-old female with ITP and sleeve gastrectomy who responded to low-dose eltrombopag 25 mg every other day, which is equivalent to 12.5 mg daily, and maintained adequate platelet counts on this dose.…”

Rhus coriaria L. (Sumac) Demonstrates Oncostatic Activity in the Therapeutic and Preventive Model of Breast Carcinoma by Peter Kubatka (11008854)

“…In addition, treated tumors showed significant dose-dependent decrease in mitotic activity index by 36.5% and 51% in comparison with the control group. …”

Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy by Samson Mathews Samuel (18808246)

“…Assays for cell proliferation, migration and tubulogenesis were also performed. We observed robust up-regulation of anti-angiogenic thrombospondin-1 (TSP1) and increased TSP1-CD36 co-localization with a marked decrease in the levels of phosphorylated vascular endothelial growth factor receptor-2 (pVEGFR2; Y1175) in 2DG (5 mM) exposed cells treated with metformin (2 mM). …”

Enhancing the corrosion resistance of reinforcing steel under aggressive operational conditions using behentrimonium chloride by A. Bahgat Radwan (9631720)

“…Using only a 50 μmol L⁻¹ of BTC, we are able to measure an inhibition efficiency of 91, 79, and 71% in SCP solution with 3.5% NaCl at pH of 12.5, 10 and 7, respectively without showing any effect on the mechanical properties on the cured mortars. …”

Did the periodic intensification of routine immunisation strategy (Intensified mission Indradhanush) reduce the demand for pediatric antibiotic formulations in India? by Habib Hasan Farooqui (7861166)

“…We conducted interrupted time series analyses by fitting a Poisson regression model. …”

Simultaneous Bilateral Neck of Femur Fracture in a Young Adult with Underlying Metabolic Disturbances by Eslam Alkaramani (14570439)

“…<em>Conclusion</em>. We report this rare case of bilateral neck of femur fracture in a young adult after a generalized seizure attack with underlying metabolic disturbances. …”

Characterizing the dynamics of climate and native desert plants in Qatar by Meshal Abdullah (17746950)

“…By analyzing Landsat satellite images from 1985 to 2022 and their relation to rainfall patterns, we found significant impacts of climatic variables on vegetation coverage, particularly after 1990. …”

Improving pediatric trauma care: an automated system for wrist trauma detection using GELAN by Promit Basak (22997776)

“…Our proposed framework surpassed the most advanced techniques, showcasing exceptional precision and effectiveness, achieving a mean average precision (mAP50) score of 74.1%, 95%, and 85.5% for Task A (trauma detection), Task B (fracture detection), and Task C (fracture severity detection), respectively. …”

BRET-Based Biosensors for Nucleic Acid Detection and Impact of Molecular Crowding Monitoring by Asfia Sultana (19170880)

“…</p><p dir="ltr">We observed the structural fluctuation of flexible linker compared to rigid linker. …”

Comprehensive thermoeconomic, exergoeconomic, and optimization analyses of direct oxy‐combustion supercritical CO₂ intercooled and reheated cycles under design and off‐d... by Wahib A. Al‐Ammari (18877408)

“…At design conditions (high‐pressure of <i>P</i>_c,o = 20 MPa, low‐pressure of <i>P</i>_c,o = 5.4 MPa, TIT = 750°C, CIT = 50°C [dry‐cooling]), the PIC has the highest thermal efficiency (47.78%) compared to 38.36% for DRC, 45.71% for ICC, and 44.39% for RHC. …”

Excess pCO₂ and carbonate system geochemistry in surface seawater of the exclusive economic zone of Qatar (Arabian Gulf) by Connor Izumi (17337868)

“…Its values in the Gulf ranged from −50 to −310 μmol kg⁻¹ implying CaCO₃ precipitation. …”

Trends in prevalence of blindness and distance and near vision impairment over 30 years: an analysis for the Global Burden of Disease Study by Rupert Bourne (603842)

“…Globally, between 1990 and 2020, among adults aged 50 years or older, age-standardised prevalence of blindness decreased by 28·5% (–29·4 to −27·7) and prevalence of mild vision impairment decreased slightly (–0·3%, −0·8 to −0·2), whereas prevalence of moderate and severe vision impairment increased slightly (2·5%, 1·9 to 3·2; insufficient data were available to calculate this statistic for vision impairment from uncorrected presbyopia). …”

The protective role of lidocaine in surgeries involving trigeminal nerve manipulation: a meta-analysis of trigeminocardiac reflex prevention by Almonzer Al-Qiami (22393303)

“…This leads to a rapid increase in parasympathetic activity, resulting in a decrease in heart rate (HR) and blood pressure, which can potentially lead to bradycardia, and cardiac arrest, with a prevalence of 14.5% during neurointerventional procedures (8). …”