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Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice
Published 2023“…<p dir="ltr">Metabolic reprogramming is one of the hallmarks of tumorigenesis. Here, we show that nuclear myosin 1 (NM1) serves as a key regulator of cellular metabolism. …”
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Epstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update
Published 2018“…Here, we provide a review of the EBV epidemiology and the genetic variability of the oncogene LMP-1. …”
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In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation
Published 2013“…We observed ATP depletion under OGD vs. hypoxia and propose that ATP depletion enhances translational suppression, overcoming the selective synthesis of HIF concurrent with global decreases in protein synthesis in hypoxia. Taken together, these findings biochemically characterize a practical reporter for monitoring HIF-1α levels and support a novel model for HIF regulation in an in vitro model of human ischemia.…”
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Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent
Published 2019“…Ovarian cancer cell lines were negative for annexinV staining while showing loss of membrane integrity and absence of caspase activation, indicating caspase-independent, non-apoptotic cell death. [HuArgI (Co)-PEG5000]-induced arginine deprivation led to extensive and prolonged activation of autophagy, which proved to be deleterious to cell survival since its inhibition led to a significant decrease in cytotoxicity. …”
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PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications
Published 2019“…<p>Tumor progression through immune evasion is a major challenge in cancer therapy. Recent studies revealed that enhanced PD-L1 expression in cancer stem cells is linked to immune evasion. …”
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The contribution of autophagy in glioblastoma multiforme cells treated with human recombinant arginase I-induced arginine deprivation. (c2018)
Published 2018“…Moreover, it is resistant to traditional chemotherapies and radiotherapies. All this results in a poor survival rate in GBM patients, which doesn’t exceed 1 year. …”
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Secrecy Performance of a RIS-Assisted Wireless Network: A Comprehensive Analysis Under Outdated CSI
Published 2025“…Moreover, increasing the number of REs can mitigate CSI aging effects where an SOP level of 3×10<sup>−5</sup> can be achieved with 140 REs at <i>ρ</i>=0.9 in the absence of a transmitter-receiver direct link. …”
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Women’s empowerment as a determinant of neonatal mortality in Sub-Saharan Africa: a narrative review focused on Nigeria
Published 2024“…</p><h2>Other Information</h2><p dir="ltr">Published in: Global Health Action<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1080/16549716.2024.2394256" target="_blank">https://dx.doi.org/10.1080/16549716.2024.2394256</a></p>…”
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Origin of arrhythmias in a heart model
Published 2009“…An investigation of the nonlinear dynamics of a heart model is presented. The model compartmentalizes the heart into one part that beats autonomously (the x oscillator), representing the pacemaker or SA node, and a second part that beats only if excited by a signal originating outside itself (the y oscillator), representing typical cardiac tissue. …”
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A Numerical Study of Heat Transfer and Fluid Flow in a Channel with an Array of Pin Fins in Aligned and Staggered Configurations
Published 2018“…Fin array configurations with large spacing ratio, S*, showed a better performance than smaller spacing ones. …”
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Targeting arginine auxotrophy in pancreatic cancer cells using human recombinant arginase I-induced arginine deprivation. (c2017)
Published 2017“…This absence of caspase activation was confirmed by a 72 hours cytotoxicity assay on Panc-1 cells, which revealed the failure of the pan-caspase inhibitor, Z-VAD, to reverse or decrease arginine depletion-triggered cell death. …”
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Wales’ tourists not a burden for local healthcare
Published 2016“…</i></p><p></p><h2>Other Information</h2><p>Published in: QScience.com Highlights, Published by Nature Research for Hamad bin Khalifa University Press (HBKU Press)<br>License: <a>http://creativecommons.org/licenses/by/4.0</a><br></p>…”
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A clustering metaheuristic for large orienteering problems
Published 2022“…</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: PLOS ONE<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1371/journal.pone.0271751" target="_blank">https://dx.doi.org/10.1371/journal.pone.0271751</a></p>…”
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When Should a Brain MRI Be Performed in Children with New-Onset Seizures? Results of a Large Prospective Trial
Published 2021“…Univariate analysis showed a significant increase in the frequency of epileptogenic lesions with decreasing age, the presence of developmental delay, and the number and types of seizures at presentation. …”
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Prehospital plasma transfusion versus standard of care following traumatic injury: a review of the systematic reviews and a meta-analysis
Published 2025“…</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: European Journal of Trauma and Emergency Surgery<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00068-025-03033-z" target="_blank">https://dx.doi.org/10.1007/s00068-025-03033-z</a></p>…”
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Inhibiting HSP90 changes the expression pattern of PINK1 and BNIP3 and induces oxidative stress in colon cancer cells
Published 2025“…Similarly, genetic knockdown of HSP90 in RKO cells produced comparable effects, including reduced cell survival and a decreased PINK1/BNIP3 ratio.</p><h3>Conclusion</h3><p dir="ltr">Targeting HSP90 in colon cancer cells disrupts their survival by decreasing PINK1 and increasing BNIP3, which activates oxidative and endoplasmic reticulum stress, ultimately triggering apoptosis.…”
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Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?
Published 2021“…<h3>Introduction</h3><p dir="ltr">Neuropilin-1(NRP1) is a cofactor that enhances SARS-CoV-2 coronavirus cell infectivity when co-expressed with angiotensin-converting enzyme 2(ACE2). …”
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