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Decreased Expression and Activity of cAMP Phosphodiesterases in Cardiac Hypertrophy and Its Impact on β-Adrenergic cAMP Signals
Published 2009“…The inotropic response to maximal β-adrenergic stimulation was reduced by ≈54% in isolated hypertrophied hearts, along with a ≈32% decrease in subsarcolemmal cAMP levels in hypertrophied myocytes. …”
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Decreased phosphodiesterase activities in cardiac hypertrophy
Published 2007“…There is limited information on the changes in cardiac cyclic nucleotide phosphodiesterases (PDE1 to PDE5) during hypertrophy and the functional consequences on the cAMP pathway. …”
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The effect of foeniculum vulgare seeds on lipidemia, glycemia & liver enzymes. (c2009)
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Assessment of the use of dolomite for the recovery of ammonia from field landfill leachate. (c2019)
Published 2019“…However, using dolomite calcined at 950 °C with the same phosphate source showed a significant decrease in removal efficiency to 44%, while using dolomite calcined at 750 °C (under continuous CO2 injection) resulted in a removal efficiency of 37%. …”
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Metformin inhibits 2D and 3D motility in astrocytoma cancer cells. (c2014)
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Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications
Published 2019“…<p dir="ltr">Triple-negative breast cancer (TNBC) accounts for ~15–20% of breast cancer (BC) and has a higher rate of early relapse and mortality compared to other subtypes. The Chemokine (C-C motif) ligand 5 (CCL5) and its signaling pathway have been linked to TNBC. …”
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Ferroelectric Properties and Electrocaloric Effect in Dy2O3 Substitution on Lead-Free (Na0.5 Bi0.5)0.94 Ba0.06TiO3 Ceramic
Published 2023“…Using the direct EC measurement, the ceramic corresponding to y = 0.02 exhibited a significant EC response, where ΔT = 1.2 K under 5 kV/mm. The incorporation of Dy was found to enhance the EC responsivity coefficient ζ = iT/ΔE), with a best value of ζ = 0.24 K.mm/kV for y = 0.02.…”
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A genetically encoded BRET-based SARS-CoV-2 Mpro protease activity sensor
Published 2022“…Further, in vitro assays with the BRET-based Mpro sensors revealed a molecular crowding-mediated increase in the rate of M<sup>pro</sup> activity and a decrease in the inhibitory potential of GC376. The sensors developed here will find direct utility in studies related to drug discovery targeting the SARS-CoV-2 M<sup>pro</sup> and functional genomics application to determine the effect of sequence variation in M<sup>pro</sup>.…”
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Dielectric Properties of Y3Fe5O12 (YIG) Prepared at Different Molarities of NaOH
Published 2020“…In this study, Yttrium Iron Garnet (Y3Fe5O12) (YIG) powders were synthesized via co-precipitation method, followed by calcining the precipitates at 1100˚C. …”
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Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies
Published 2021“…Here, metformin significantly decreased VISTA and AHR levels in vitro and in vivo. …”
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