يعرض 141 - 160 نتائج من 8,287 نتيجة بحث عن '(( 50 ppm decrease ) OR ((((( 50 ng decrease ) OR ( 50 c decrease ))) OR ( 5 ng decrease ))))', وقت الاستعلام: 0.87s تنقيح النتائج
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    Subject flow diagram. حسب Joseph Rabin (7399436)

    منشور في 2023
    الموضوعات:
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    First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation حسب Kairui Yue (11874403)

    منشور في 2022
    "…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC<sub>50</sub> value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC<sub>0‑inf</sub> (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …"
  8. 148

    First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation حسب Kairui Yue (11874403)

    منشور في 2022
    "…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC<sub>50</sub> value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC<sub>0‑inf</sub> (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …"
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    Inhibition of pan- and HDAC isoform activities. حسب Mira Jung (1277502)

    منشور في 2024
    "…Cellular growth inhibition studies show that SP-1-303 differentially inhibits growth of estrogen receptor positive breast cancer (ER+ BC) cells with effective growth inhibition concentrations (EC<sub>50</sub>) for MCF-7 and T47D cells ranging from 0.32 to 0.34 μM, compared to 1.2–2.5 μM for triple negative breast cancer cells, and ~12 μM for normal breast epithelial cells. …"