Effect of melatonin (50 μM) on the TGF-β1 (10 ng/mL, 72 h)-mediated TGF-β1/Smad pathway and EMT in HBdSMCs. by Yang Zhang (30734)

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

Subjects:

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

Subjects:

Detection of the Challenging mutations at 1% VAF and 50 ng DNA input. by Lizhi Yu (12476136)

IC₅₀s data of antimalarials against controls. by Winnie Okore (14139712)

Subjects:

Drugs IC₅₀s data during the study period. by Winnie Okore (14139712)

Subjects:

Transcriptional and translational markers of syncytialization and biochemical differentiation are significantly decreased by rotenone. by O’Llenecia S. Walker (8486163)

SNPs IC₅₀s data at codon 876 during the study period. by Winnie Okore (14139712)

Subjects:

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Representative inhibitor <b>35m</b> exhibits potent HDAC6 inhibitory activity with an IC₅₀ value of 0.019 μM. To our surprise, <b>35m</b> establishes significant improvement in the pharmacokinetic property with much higher AUC_0‑inf (10292 ng·h/mL) and oral bioavailability (93.4%) than hydroximic acid-based HDAC6 inhibitors Tubastatin A and ACY-1215. …”

Decreasing fluconazole susceptibility of clinical South African <i>Cryptococcus neoformans</i> isolates over a decade by Serisha D. Naicker (8648370)

The decrease in blood flow disrupts CV pruning. by Lin Wen (557398)

Single-channel properties of L-AChRs activated by 10 μM ACh, 100 μM ACh or 100 μM levamisole in the absence and presence of terpenoids. by Guillermina Hernando (553795)

<b>Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decrease ISR activation in DRG neurons</b> by Muhammad Saad Yousuf (20745168)

H& E staining investigation of CAM treated with native-orientin (5 μM), native-orientin (10 μM), NF-O (5 μM), and NF-O (10 μM). by Yashwanth Elumalai (21743452)

Association of polymorphic IC_50s versus wild<i>-</i>type at codon 876 in selected drugs tested. by Winnie Okore (14139712)

Subjects:

1-hr treatment with 10μM PF573228 or 10μM PD98059 in Caco-2 cells. by Sema Oncel (10152053)

Kinase profiler assay of 1C8 (10 μM). by Florentin Pastor (19852287)

Illustrates photographs of the CAM were captured to visualize the vascular plexus following the control group, native-orientin (5 μM), native-orientin (10 μM), NF-O (5 μM), and NF-... by Yashwanth Elumalai (21743452)

Treatment with 10μM benidipine decreases N8-3C3 NKT hybridoma cell activation and IL-2 production. by Andrés F. Londoño (6857828)

“…L-CD1d endogenous lipids activate NKT cells to produce IL-2, and the addition of RP antigen enhances NKT cell activation and IL-2 production. The addition of 10μM benidipine significantly decreased NKT cell activation and IL-2 production. …”