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P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis
منشور في 2010"…Consistent with this, P-gp function was also increased by 1.5-fold and riluzole brain disposition was decreased by 1.7-fold in mSOD1 mice. …"
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Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic anal...
منشور في 2020"…Under-5 deaths declined from 9·6 million (9·1–10·3) in 2000 to 5·0 million (4·3–6·0) in 2019. …"
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Nonlinear effects in locally resonant nanostrip phononic metasurface at GHz frequencies
منشور في 2021"…<p dir="ltr">In this paper, we report on the observation of nonlinear effects in a nanostrip phononic metasurface (NPM) that enable the tuning of resonance frequencies at 1.42 GHz. …"
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Predicting stability of classes in an object-oriented system
منشور في 2010"…We compare our results to the machine learning algorithm C4.5, and we show that our approach out-beats it.…"
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Effect of sintering temperature of NBT–6BT lead-free ceramics on the structural, ferroelectric and piezoelectric properties
منشور في 2022"…It is found that the optimal ferroelectric and piezoelectric values were obtained at 1150 °C (P r = 27 µC/cm 2 , E c = 3.89 kV/mm and d 33 = 110 pC/N). According to these results, we suggest that 850 °C and 1150 °C can be considered as optimal calcination and sintering temperature in NBT-6BT ceramic, respectively.…"
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207
Changes in Blood microRNA Expression and Early Metabolic Responsiveness 21 Days Following Bariatric Surgery
منشور في 2019"…Following multiple comparison adjustment, changes in seven microRNAs remained significant: miR-7-5p, let-7f-5p, miR-15b-5p, let-7i-5p, miR-320c, miR-205-5p, and miR-335-5p. …"
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Angiotensin II AT1 receptor internalization, translocation and de novo synthesis modulate cytosolic and nuclear calcium in human vascular smooth muscle cells
منشور في 2003"…Overexpression of hAT1R and hAT1R GFP decreased both basal cytosolic and nuclear Ca2+. In normal hVSMCs and low hAT1R GFP overexpressing hVSMCs, Ang II (10 15 to 10 4 M) induced a dose-dependent sustained increase of [Ca]c and [Ca]n with an EC50 near 5 × 10 11 and 5 × 10 9 M, respectively. …"
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Role of Edge Groups in Defining the Stability of Aromatic Molecules Under Electron Irradiation
منشور في 2024"…<p dir="ltr">Electron irradiation is known to be an important physical tool in tuning the properties of self-assembled organic molecules. Here, we use X-ray photoelectron spectroscopy (XPS) measurements to study the effect of electron bombardment on the structural properties of dithiol aromatic molecules, where the sulfur atoms are either in direct conjugation with phenyl rings (case of Biphenyl-4,4′-dithiol, BPN) or separated by a methylene group (case of 5,5′-bis(mercaptomethyl)-2,2′-bipyridine, BPD). …"
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Past and future climate effects on population structure and diversity of North Pacific surfgrasses
منشور في 2024"…We predicted the distribution of the species for the present, LGM, and near future (RCP 8.5, no climate mitigation) using Species Distribution Models (SDMs).…"
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A single-institution review of 157 patients presenting with benign and malignant tumors of the ampulla of Vater
منشور في 2011"…For ampullary adenocarcinoma postoperative survival rates are rising. Recent series report 5-year postoperative survival rates of 53–68%.7 Successful endoscopic removal of high-grade intraepithelial neoplasia, in situ tumors, and focal T1 cancers has been reported, but is not widely practiced.8, 9 and 10 For patients with slow-growing benign tumors, endoscopic resection is an attractive alternative with decreased cost and morbidity.11 and 12 Endoscopic papillectomy has a recurrence rate of 30% with 13.9% of endoscopically treated patients subsequently undergoing follow-up surgery. …"
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Optimal management, prevalence, and clinical behavior of saddle pulmonary embolism: A systematic review and meta-analysis
منشور في 2022"…The use of TT was significantly associated with increased survival (27.1 % vs. 12.5 %, p < 0.001). In a multivariate logistic regression model, massive PE features significantly increased the odds of death (OR: 29.3, CI: 4.86–181.81, p < 0.001), whereas, treatment with anticoagulation (AC) alone (OR: 0.1, CI: 0.027–0.356, p < 0.001), TT (OR: 0.065, CI: 0.019–0.26, p < 0.001), surgical thrombectomy (ST) (OR: 0.047, CI: (0.010–0.23), p < 0.001), or percutaneous thrombectomy (PT) (OR: 0.12, CI: 0.020–0.84, p = 0.032) significantly decreased odds of death.…"
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The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study
منشور في 2022"…Blood samples were taken at every other visit to measure levels of total T (TT), calculated free T, sex hormone-binding globulin (SHBG), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone and prolactin. We observed an increase in TT of 15.5 nmol/L (<i>p</i> < 0.0001), a reduction in SHBG of 10.5 nmol/L (<i>p</i> < 0.0001) and an increase in calculated free T of 383.04 pmol/L (<i>p</i> < 0.0001) over the study period. …"
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High-sensitive detection and quantitation of thyroid-stimulating hormone (TSH) from capillary/fingerstick and venepuncture whole-blood using fluorescence-based rapid lateral flow i...
منشور في 2023"…These key performance indicators were slightly decreased when fingerstick whole-blood samples were used: sensitivity [85.7 %(63.7–97)], specificity [90.0 %,(81.5–96)], good agreement (Cohen's Kappa = 0.7) and very strong correlation (r = 0.9, p < 0.0001) with cobas® e 601. …"
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