Electrically Controlled Lasing in Supercooled Liquid Crystal Blue Phase I Microdroplets حسب Gia Petriashvili (8920925)

"…When the electric field intensity is increased, the lasing intensity is increased too along with the linewidth that decreases from 6 to 2.5 nm. Besides, the laser lines were shifted toward the shorter wavelength by 11 nm. …"

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor حسب Anat Levit Kaplan (12126567)

"…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …"

Structure-Based Design of a Chemical Probe Set for the 5‑HT_5A Serotonin Receptor حسب Anat Levit Kaplan (12126567)

"…Docking over 6 million molecules against a 5-HT_5AR homology model identified 5 mid-μM ligands, one of which was optimized to <b>UCSF678</b>, a 42 nM arrestin-biased partial agonist at the 5-HT_5AR with a more restricted off-target profile and decreased assay liabilities versus SB-699551. …"

Analysis of NIST Monoclonal Antibody Reference Material Glycosylation Using the LC–MS/MS-Based Glycoproteomic Approach حسب Jingfu Zhao (3113421)

"…Glycosylation is an essential critical quality attribute (CQA) due to the influence that glycoforms have on the safety, efficacy, and pharmacokinetics/pharmacodynamics (PK/PD) of biotherapeutics. Here, we applied an LC–MS/MS-based glycoproteomics approach to characterize Fc glycans of an NISTmAb reference material (RM) 8671 (sample B) and a β-1,4-galactosidase-treated NISTmAb (sample A). …"

Global level of 5mC and of H3K9ac in ovine SCNT embryos. حسب Parisa Nadri (13132252)

Bidirectional Optical Control of Proton Motive Force in Escherichia coli Using Microbial Rhodopsins حسب Kotaro Nakanishi (3389300)

"…Tethered cell experiments revealed that, upon illumination, the torque of the flagellar motor decreased to nearly zero (28 pN nm) with <i>Rm</i>XeR, while it increased to 1170 pN nm with AR3. …"

Bidirectional Optical Control of Proton Motive Force in Escherichia coli Using Microbial Rhodopsins حسب Kotaro Nakanishi (3389300)

"…Tethered cell experiments revealed that, upon illumination, the torque of the flagellar motor decreased to nearly zero (28 pN nm) with <i>Rm</i>XeR, while it increased to 1170 pN nm with AR3. …"

Bidirectional Optical Control of Proton Motive Force in Escherichia coli Using Microbial Rhodopsins حسب Kotaro Nakanishi (3389300)

"…Tethered cell experiments revealed that, upon illumination, the torque of the flagellar motor decreased to nearly zero (28 pN nm) with <i>Rm</i>XeR, while it increased to 1170 pN nm with AR3. …"

Bidirectional Optical Control of Proton Motive Force in Escherichia coli Using Microbial Rhodopsins حسب Kotaro Nakanishi (3389300)

"…Tethered cell experiments revealed that, upon illumination, the torque of the flagellar motor decreased to nearly zero (28 pN nm) with <i>Rm</i>XeR, while it increased to 1170 pN nm with AR3. …"

Chemical compositions of <i>U.simensis</i> essential oil identified through GC-MS analysis. حسب Bickes Wube (21678222)

The decrease or inhibition of Hsp90 induced REST degradation. حسب Raúl Orozco-Díaz (7067624)

"…(D) The level of REST dramatically reduced in differentiated SH-SY5Y cells treated with GA (1 μM) or PU-H71 (50 nM) at 24 h. …"

Decrease in vRNA in brain during antiretroviral therapy. حسب Sonny R. Elizaldi (9684796)

MigC interacts with and decreases the activity of MurD. حسب Jeanette M. Critchlow (21553796)

Molecular Simulations Probing the Adsorption and Diffusion of Ammonia, Nitrogen, Hydrogen, and Their Mixtures in Bulk MFI Zeolite and MFI Nanosheets at High Temperature and Pressur... حسب Roshan Patel (10727011)

الموضوعات:

Ratio of inter- and intra-chromosome DSB clustering (inter/intra CD Ratio) for a range of simulated cell-types, LET (keV/<i>μ</i>m) and cluster radius (nm). حسب Samuel P. Ingram (9854133)

Discovery of Novel Imidazo[4,5‑<i>c</i>]quinoline Derivatives to Treat Inflammatory Bowel Disease (IBD) by Inhibiting Multiple Proinflammatory Signaling Pathways and Restoring Inte... حسب Xuewu Liang (3071676)

"…Especially, lead compound <b>8l</b> showed potent inhibitory activities against interferon-stimulated genes (IC₅₀: 3.3 nM) and NF-κB pathways (IC₅₀: 150.7 nM) and decreased the release of various proinflammatory factors at the nanomolar level, including IL-6, IL-8, IL-1β, TNF-α, IL-12, and IFN-γ. …"

Water-Assisted Proton Transport in Confined Nanochannels حسب Xinyou Ma (3697816)

"…Herein, excess proton confinement effects are computationally investigated for sub-2 nm hydrophobic nanopores by varying the diameters (<i>d</i> = 0.81, 0.95, 1.09, 1.22, 1.36, 1.63, and 1.90 nm), lengths (<i>l</i> ∼3 and ∼5 nm), curvature, and chirality of cylindrical carbon nanotube (CNT) nanopores. …"

Water-Assisted Proton Transport in Confined Nanochannels حسب Xinyou Ma (3697816)

"…Herein, excess proton confinement effects are computationally investigated for sub-2 nm hydrophobic nanopores by varying the diameters (<i>d</i> = 0.81, 0.95, 1.09, 1.22, 1.36, 1.63, and 1.90 nm), lengths (<i>l</i> ∼3 and ∼5 nm), curvature, and chirality of cylindrical carbon nanotube (CNT) nanopores. …"

Water-Assisted Proton Transport in Confined Nanochannels حسب Xinyou Ma (3697816)

"…Herein, excess proton confinement effects are computationally investigated for sub-2 nm hydrophobic nanopores by varying the diameters (<i>d</i> = 0.81, 0.95, 1.09, 1.22, 1.36, 1.63, and 1.90 nm), lengths (<i>l</i> ∼3 and ∼5 nm), curvature, and chirality of cylindrical carbon nanotube (CNT) nanopores. …"

Percentage drug content of MF-CS-NPs stored at 25 ± 2°C, 65% ± 5% RH after 0–6 months storage. حسب Alireza Latifi (14593561)