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Modulation of SLFN11 induces changes in DNA Damage response in breast cancer
Published 2023“…We then used the modified cell lines to quantify the alteration in chemo sensitivity of those cells to treatment with DNA Damaging Agents (DDAs) such as Cisplatin and Epirubicin or DNA Damage Response (DDRs) drugs like Olaparib. …”
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Ecotoxicological Assessment of Thermally- and Hydrogen-Reduced Graphene Oxide/TiO<sub>2</sub> Photocatalytic Nanocomposites Using the Zebrafish Embryo Model
Published 2019“…Using the zebrafish embryo model, we investigated the environmental impacts of two thermally (RGOTi)- and hydrogen (H<sub>2</sub>RGOTi)-reduced graphene oxide/TiO<sub>2</sub> semiconductor photocatalysts recently employed in AOPs. …”
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The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in <i>Drosophila melanogaster</i>
Published 2023“…One such gene is the single-stranded DNA-binding protein 3 (<i>SSBP3</i>) and its Drosophila melanogaster ortholog is called sequence-specific single-stranded DNA-binding protein (<i>Ssdp</i>). …”
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Machine Learning-Based Management of Electric Vehicles Charging: Towards Highly-Dispersed Fast Chargers
Published 2020“…LSTM provided the best results with an accuracy of 95% for predicting the most appropriate power rating (PR) for EVCS, followed by RF, DT, DNN, SVM, KNN, and NB. Additionally, LSTM was also the model with the smallest error rate, at a value of ±0.7%, followed by RF, DT, KNN, SVM, DNN, and NB. …”
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Adult appendicitis score versus Alvarado score: A comparative study in the diagnosis of acute appendicitis
Published 2023“…We aim to assess the adult appendicitis score (AAS) in the diagnosis prediction of AA.…”
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BRET-Based Biosensors for Nucleic Acid Detection and Impact of Molecular Crowding Monitoring
Published 2024“…Our work extended to designing BioNADs targeting SARS-CoV-2 variants by conjugating specific, fluorescently modified molecular beacons to NLuc-functionalized DNA for viral nucleic acid detection. Moreover, our study revealed that the decrease in BRET efficiency of BioNADs upon viral oligo binding could be visualized as a color change using a cell phone camera. …”
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The Impact of COVID-19 on the HIV Cascade of Care in Botswana – An Interrupted Time Series
Published 2024“…In multivariable Poisson interrupted time series regression, the COVID-19 lockdown was associated with a 27% decrease in the monthly numbers of HIV tests (IRR 0.73, 95%CI 0.72–0.73), a 25% decrease in HIV positive tests (IRR 0.75, 95%CI 0.71–0.79), and a 43% reduction in ART initiations (IRR 0.57, 95%CI 0.55–0.60). …”
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BRET-based biosensors for SARS-CoV-2 oligonucleotide detection
Published 2024“…Specifically, we designed BioODs against the SARS-CoV-2 parental (Wuhan strain) and B.1.617.2 Delta variant through the conjugation of specific, fluorescently modified molecular beacons (sensor module) through a complementary oligonucleotide handle DNA functionalized with the NanoLuc (NLuc) luciferase protein such that the dissolution of the molecular beacon loop upon the binding of the viral oligonucleotide will result in a decrease in BRET efficiency and, thus, a change in the bioluminescence spectra. …”
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Assessment Tools for Pulmonary Involvement in Patients with Ankylosing Spondylitis: Is Diaphragmatic Ultrasonography Correlated to Spirometry?
Published 2023“…</p><h3>Methods</h3><p dir="ltr">We conducted a cross-sectional study of 50 patients with radiographic SpA, over six months. …”
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Prevalence and Phylogenetic Analysis of Parvovirus (B19V) among Blood Donors with Different Nationalities Residing in Qatar
Published 2021“…Results: Only 1.4% (70/5026) of the samples had detectible B19V DNA in their blood. B19V DNA prevalence statistically decreased with age (p = 0.03). …”
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Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling
Published 2019“…SNG treatment of MM cells resulted in a dose-dependent decrease in cell viability through mitochondrial membrane potential loss and activation of caspase 3, 9, and cleavage of PARP. …”
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Regional variations in incidence of surgical site infection and associated risk factors in women undergoing cesarean section: A systematic review and Meta-Analysis
Published 2025“…The SSI incidence in LMICs was 8.0 % (95 % CI: 6.0 %–10.0 %) with moderate certainty, while the incidence in HICs was 5.0 % (95 % CI: 4.0 %–7.0 %) with low certainty. …”
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Sleeve Gastrectomy in Patients with Type 2 Diabetes: Anthropometric and Cardiometabolic Improvements at 1, 3, 5, 7, and 9 years—Are the Initial Benefits Sustained?
Published 2025“…<h3>Background</h3><p dir="ltr">No previous study assessed the outcomes of sleeve gastrectomy (SG) beyond 5 years among adult patients with type 2 diabetes (T2DM). We appraised the evolution of 20 outcomes at 1, 3, 5, 7, and 9 years.…”
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Technical assessment of different extraction methods and transcriptome profiling of RNA isolated from small volumes of blood
Published 2023“…The samples isolated manually displayed a higher variability in the transcriptomic data as compared to the other samples. The TURBO DNA Free treatment affected the RNA samples negatively, decreasing the RNA yield and reducing the quality and reproducibility of the transcriptomic data. …”
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Predictors of mortality and morbidity in critically ill COVID‐19 patients: An experience from a low mortality country
Published 2022“…The median (IQR) age of patients was 50 (41–59) years. Diabetes (47.3%) and hypertension (42.6%) were the most common comorbidities. …”