Transient and stable knock-down of ADAM10 suppresses APLP2 shedding. by Sebastian Hogl (349573)

“…<p>(<b>A</b>) SH-SY5Y cells were transfected with siRNA pools against the proteases ADAM10 (A10KD) or ADAM17 (A17KD) or with control siRNA (Con). …”

Presentation1_Effects of Chang-Kang-Fang Formula on the Microbiota-Gut-Brain Axis in Rats With Irritable Bowel Syndrome.zip by Xiwen Ling (12518065)

“…Recent studies show that 5.0 g/kg/d CKF can alleviate the symptoms of IBS rats by modulating the brain-gut axis through the production of brain-gut peptides (BGPs), thus relieving pain, and reversing the effects of intestinal propulsion disorders. …”

Preparation and Characterization of Homologous Diiron Dithiolato, Diselenato, and Ditellurato Complexes: [FeFe]-Hydrogenase Models by Mohammad K. Harb (2331892)

“…Treatment of Fe₃(CO)₁₂ with 3,3-bis(thiocyanatomethyl)oxetane (<b>1</b>) or a mixture of 2-oxa-6,7-dithiaspiro[3.4]octane (<b>2a</b>) and 2-oxa-6,7,8-trithiaspiro[3.5]nonane (<b>2b</b>) in toluene at reflux afforded the model compound Fe₂(μ-S₂C₅H₈O)(CO)₆ (<b>3</b>). …”

Decision boundary dynamics modulated by theta activity. by Nadja R. Ging-Jehli (10925910)

“…<p><b>(A)</b> Exemplified scheme for integrating mean activation in theta-frequency band during pre-response (z-scored mean activation during the last 500 ms before response) and poststimulus (z-scored mean activation during the first 500 ms after stimulus onset) periods as trial-based neural regressors into the best-fitting model. …”

Mechanistic Mathematical Modeling Tests Hypotheses of the Neurovascular Coupling in fMRI - Fig 1 by Karin Lundengård (2549458)

“…If the model is accepted, the model is minimized in order to identify key mechanisms of the system (4) and core predictions of not yet performed experiments are made (5). In the next step, new data are collected, using experimental setup based on previous predictions, and the model predictions are compared to the new data set (6). …”

Image_1_Pcgf1 Regulates Early Neural Tube Development Through Histone Methylation in Zebrafish.TIF by Xinyue Li (628935)

“…<p>The neural induction constitutes the initial step in the generation of the neural tube. Pcgf1, as one of six Pcgf paralogs, is a maternally expressed gene, but its role and mechanism in early neural induction during neural tube development have not yet been explored. …”

Effect of positive end-expiratory pressure (PEEP) on left ventricular (LV) filling by Thomas Luecke (62130)

Age-Associated Lipidome Changes in Metaphase II Mouse Oocytes by Hyuck Jun Mok (600066)

“…To investigate if aged oocytes display an altered lipidome compared to young oocytes, we performed a global lipidomic analysis between oocytes from 4-week-old and 42 to 50-week-old mice. …”

Synaptic boutons located on the same axon have similar endogenous Ca²⁺ buffering capacity. by Yaroslav S. Ermolyuk (135824)

“…Next, the average amplitude Δ<i>F/F_m</i> and the average τ₅₀ were calculated for each group followed by calculation of and . …”

DataSheet_1_An integrative multi-omic analysis defines gut microbiota, mycobiota, and metabolic fingerprints in ulcerative colitis patients.docx by Matteo Scanu (13197234)

“…</p>Results<p>In the UC cohort, we reported the increase of Streptococcus, Bifidobacterium, Enterobacteriaceae, TM7-3, Granulicatella, Peptostreptococcus, Lactobacillus, Veillonella, Enterococcus, Peptoniphilus, Gemellaceae, and phenylethyl alcohol; and we also reported the decrease of Akkermansia; Ruminococcaceae; Ruminococcus; Gemmiger; Methanobrevibacter; Oscillospira; Coprococus; Christensenellaceae; Clavispora; Vishniacozyma; Quambalaria; hexadecane; cyclopentadecane; 5-hepten-2-ol, 6 methyl; 3-carene; caryophyllene; p-Cresol; 2-butenal; indole, 3-methyl-; 6-methyl-3,5-heptadiene-2-one; 5-octadecene; and 5-hepten-2-one, 6 methyl. …”

LGR4 is required for RSPO1-induced Wnt/β-catenin signaling. by Heinz Ruffner (150990)

“…(b) Expression of LGR4, LGR5 and LGR6 rescue LGR4 siRNA-elicited decrease in RSPO1-induced STF reporter activation. …”

Table_1_The Extent of Alcohol-Related Problems Among College and University Students in Norway Prior to and During the COVID-19 Pandemic.DOCX by Ove Heradstveit (10307177)

“…</p>Findings<p>37.0% of male students and 24.1% of female students reported either risky, harmful, or dependent alcohol use in 2021, compared with 55.0% of male students and 43.6% of female students in 2018. This decrease in alcohol-related problems was most pronounced for dependent alcohol use, where we observed a 57% relative reduction among male students (from 3.5% in 2018 to 1.5% in 2021) and a 64% relative reduction among female students (from 1.4% in 2018 to 0.5% in 2021).…”

data.zip by Dapang Rao (11031348)

“…</a> In addition, INPP4B、HPGD、IGFBP5 and IL1R2 genes were upregulated, and PRKACB、TMSB4X and CCND1 downregulated in DOCK1 knockout cells. …”

Synthesis and Activity of Ruthenium Olefin Metathesis Catalysts Coordinated with Thiazol-2-ylidene Ligands by Georgios C. Vougioukalakis (2290621)

“…In the solid state, the aryl substituents of the thiazole-2-ylidene ligands are located above the empty coordination site of the ruthenium center. Despite the decreased steric bulk of their ligands, all of the complexes reported herein efficiently promote benchmark olefin metathesis reactions such as the ring-closing of diethyldiallyl and diethylallylmethallyl malonate and the ring-opening metathesis polymerization of 1,5-cyclooctadiene and norbornene, as well as the cross metathesis of allyl benzene with <i>cis</i>-1,4-diacetoxy-2-butene and the macrocyclic ring-closing of a 14-membered lactone. …”

Synthesis and Activity of Ruthenium Olefin Metathesis Catalysts Coordinated with Thiazol-2-ylidene Ligands by Georgios C. Vougioukalakis (2290621)

“…In the solid state, the aryl substituents of the thiazole-2-ylidene ligands are located above the empty coordination site of the ruthenium center. Despite the decreased steric bulk of their ligands, all of the complexes reported herein efficiently promote benchmark olefin metathesis reactions such as the ring-closing of diethyldiallyl and diethylallylmethallyl malonate and the ring-opening metathesis polymerization of 1,5-cyclooctadiene and norbornene, as well as the cross metathesis of allyl benzene with <i>cis</i>-1,4-diacetoxy-2-butene and the macrocyclic ring-closing of a 14-membered lactone. …”

Synthesis and Activity of Ruthenium Olefin Metathesis Catalysts Coordinated with Thiazol-2-ylidene Ligands by Georgios C. Vougioukalakis (2290621)

“…In the solid state, the aryl substituents of the thiazole-2-ylidene ligands are located above the empty coordination site of the ruthenium center. Despite the decreased steric bulk of their ligands, all of the complexes reported herein efficiently promote benchmark olefin metathesis reactions such as the ring-closing of diethyldiallyl and diethylallylmethallyl malonate and the ring-opening metathesis polymerization of 1,5-cyclooctadiene and norbornene, as well as the cross metathesis of allyl benzene with <i>cis</i>-1,4-diacetoxy-2-butene and the macrocyclic ring-closing of a 14-membered lactone. …”

Synthesis and Activity of Ruthenium Olefin Metathesis Catalysts Coordinated with Thiazol-2-ylidene Ligands by Georgios C. Vougioukalakis (2290621)

“…In the solid state, the aryl substituents of the thiazole-2-ylidene ligands are located above the empty coordination site of the ruthenium center. Despite the decreased steric bulk of their ligands, all of the complexes reported herein efficiently promote benchmark olefin metathesis reactions such as the ring-closing of diethyldiallyl and diethylallylmethallyl malonate and the ring-opening metathesis polymerization of 1,5-cyclooctadiene and norbornene, as well as the cross metathesis of allyl benzene with <i>cis</i>-1,4-diacetoxy-2-butene and the macrocyclic ring-closing of a 14-membered lactone. …”

Loss of <i>bmm</i> in the somatic cells of the gonad with an independent RNAi line has no effect on triglyceride storage or breakdown in females. by Lianna W. Wat (8339454)

“…(F) Triglyceride breakdown post-starvation among 5-day-old virgin <i>c587>UAS-bmm;UAS-bmm-RNAi</i> females and control females (<i>c587</i>>+ and <i>+>UAS-bmm;UAS-bmm-RNAi</i>) showed a modest decrease of a similar magnitude at both 0–12 hours or 12–24 hours STV (<i>p</i> = 0.0043, 1.7 × 10⁻⁶, and 0.0027 for 0–12 hours and 0.0, 2.6 × 10⁻⁶, and 2.9 × 10⁻⁴ for 12–24 hours, respectively; one-way ANOVA followed by Tukey HSD test). …”

Generation of beta-lactoglobulin knock-out goats using CRISPR/Cas9 by Wenjun Zhou (310993)

“…Among the kids, the genome-targeting efficiencies of single sgRNA were 12.5% (10 ng/μL sg1) and 0% (10 ng/μL sg2) and efficiencies of dual sgRNAs were 25.0% (25 ng/μL sg2+sg3 group) and 28.6% (50 ng/μL sg2+sg3 group). …”

Supplementary Material for: Impact of Abemaciclib-induced Serum Creatinine Elevation on Dose Adjustment of Concomitant Medications by figshare admin karger (2628495)

“…After ABE discontinuation, CCr values returned to baseline levels. Overall, 50.2% of patients experienced a change in renal function classification after ABE initiation (P < 0.01), and 22.6% required dose adjustment owing to these changes. …”