Summary of the A19D unfolding pathway highlighting the main structural changes identified here that might explain its decreased thermodynamic stability. by Priscila Ferreira (498747)

Anthelmintics Derived from the Kinase Inhibitor SGI-1776 for the Treatment of Gastrointestinal Worm Infections by Mostafa A. Elfawal (22430138)

“…The unexpected SAR of compound <b>15</b> can be explained by computational modeling. We demonstrate the efficacy of optimized compound <b>50</b> as a new oral anthelmintic, which demonstrated better gut restriction properties and significantly reduced the fecundity of T. muris whipworm adults in infected mice. …”

LiCl administered via 0.5% LiCl food pellets for 4 wks does not increase markers for autophagy in <i>Gfap-</i>R236H/+ mice. by Christine M. LaPash Daniels (796881)

TGFβ1 expression was increased, and RASAL1 expression was decreased in NTM cells in response to a hypoxic environment. by Fiona McDonnell (2636635)

“…A 0hr Control was set to 100%, and the normoxic and hypoxic results were presented as a percentage of this; Normoxic = 95.5%, Hypoxic = 159.4% (P<0.01). n = 3 *P<0.05, **P<0.01. …”

LiCl administered via 0.5% LiCl food pellets for 8 wks decreases GFAP levels in surviving <i>Gfap</i>-R236H/+ mice. by Christine M. LaPash Daniels (796881)

“…<p>(A) 81.8% (9/11) +/+ mice and 54.5% (6/11) R236H/+ mice survived 8 wks of LiCl treatment. …”

Does a correlation exist between delayed vaccination and a decreased vaccine confidence? by Virginia Reverte (9046494)

“…Vaccine Confidence Index (VCI) is an indicator to estimate confidence in vaccines, composed of simple dimensions about it and evaluated using a 5-point Likert scale. Objectives of this study, conducted in the Region of Murcia, Spain, were to determine which sociodemographic factors were associated with delayed administration in measles, mumps and rubella (MMR) vaccine, both first and second doses, and to evaluate if there were differences in parental vaccine confidence of children who were delayed on MMR vaccine schedule compare to vaccinated on time. …”

Knockdown of p65 in A549 cells results in a decreased infection rate. by Janine J. Wilden (8849948)

Knockdown of OPTN decreases starvation induced formation and maturation of autophagosomes. by Kapil Sirohi (796637)

PB2 variants D605A and V606A do not affect the secondary structures of the PB2 ‘627’ domain. by Ho-Pan Hsia (4768638)

Net work vs phase of activation and lattice spacing. Top) We simulated work loops in the half sarcomere model at phases of activation of 0 to 0.95 in 0.05 increments, as well as over lattice spacings from 12 to 18 nm and plotted the new work for each condition. Bottom) We then simulated work loops over the same range, but with the stiffness of either the linear or torsional spring comprising the crossbridge head increased or decreased by 50% separately.... by Travis Carver Tune (21012349)

“…Bottom) We then simulated work loops over the same range, but with the stiffness of either the linear or torsional spring comprising the crossbridge head increased or decreased by 50% separately. …”

Controlling Electron/Hole Recombination in Near-Infrared Polymer Phototransistors through an Insulation Medium: A Pathway to Ultrahigh Photosensitivity by Tao Han (22342)

“…The Δ<i>V</i>_th value (∼29.5 ± 1.0 V) increased by approximately 4-fold, the <i>I</i>_ph/<i>I</i>_dark (∼4.4 × 10⁶) increased by a factor of 3000 to 4000-fold, and the dark current decreased by 2–3 orders of magnitude (@ <i>V</i>_g = 0 V). …”

Viability decreases in PRR15-deficient ACH-3P cells. by Katherine C. Gates (3907456)

Decreased Brain Levels of Vitamin B12 in Aging, Autism and Schizophrenia by Yiting Zhang (391974)

“…Thus our findings reveal a previously unrecognized decrease in brain vitamin B₁₂ status across the lifespan that may reflect an adaptation to increasing antioxidant demand, while accelerated deficits due to GSH deficiency may contribute to neurodevelopmental and neuropsychiatric disorders.…”

Decrease in ISV diameter exacerbates the decrease in WSS caused by hematocrit reduction. by Swe Soe Maung Ye (12895103)

Cell viability of microglial cells after 48 hour incubation with human complement components (C1q, C1 inhibitor, C4, C5 and C9), both individually and in combination with each othe... by Tharusha Jayasena (704509)

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Chemical structures of selective blockers of TASK channels contain aromatic groups and amide bonds. Using this rationale, we designed and synthesized a series of compounds based on 3-benzamidobenzoic acid. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Chemical structures of selective blockers of TASK channels contain aromatic groups and amide bonds. Using this rationale, we designed and synthesized a series of compounds based on 3-benzamidobenzoic acid. …”

FBA-TPQ preferentially decreases cell viability and growth of A2780 and OVCAR-3 cells but not normal IOSE-144 cells. by Tao Chen (75911)

ActAs and CoT prompt strategies do not result in decreased error rate for tasks with increasing complexity. by Jacqueline A. Jansen (14894276)

Self-correction prompt strategy results in decreased error rate for all tasks with increasing complexity. by Jacqueline A. Jansen (14894276)