Image_5_Single cell analysis of short-term dry eye induced changes in cornea immune cell populations.jpg by Jehan Alam (5577734)

“…T cells and resident macrophages (rMP) were the largest populations in the normal cornea comprising 18.6 and 18.2 percent, respectively. rMP increased to 55.2% of cells after 5 days of DS. Significant changes in expression of 1,365 genes (adj p < 0.0001) were noted in rMP with increases in cytokines and chemokines (Tnf, Cxcl1, Ccl12, Il1rn), inflammatory markers (Vcam, Adam17, Junb), the TAM receptor (Mertk), and decreases in complement and MHCII genes. …”

DataSheet_1_Remodeling of T Cell Dynamics During Long COVID Is Dependent on Severity of SARS-CoV-2 Infection.pdf by Milena Wiech (111682)

“…In particular, CD8+ T cells exhibit a high proportion of CD57+ terminal effector cells, together with significant decrease of naïve cell population, augmented granzyme B and IFN-γ production and unresolved inflammation 6 months after infection. …”

Image_5_Phenotypic changes of γδ T cells in Plasmodium falciparum placental malaria and pregnancy outcomes in women at delivery in Cameroon.jpeg by Chris Marco Mbianda Nana (14492776)

“…</p>Results<p>Placental Plasmodium falciparum infection was associated with significant increase in the frequency of total γδ T cells in IVBMC and of the Vδ1⁺ subset in PBMC and IVBMC, but decreased frequency of the Vδ2⁺ subset in PBMC and IVBMC. …”

Image_5_Phenotypic changes of γδ T cells in Plasmodium falciparum placental malaria and pregnancy outcomes in women at delivery in Cameroon.jpeg by Chris Marco Mbianda Nana (14492776)

“…</p>Results<p>Placental Plasmodium falciparum infection was associated with significant increase in the frequency of total γδ T cells in IVBMC and of the Vδ1⁺ subset in PBMC and IVBMC, but decreased frequency of the Vδ2⁺ subset in PBMC and IVBMC. …”

Image_5_Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators.tif by Ming Liu (105953)

“…Similarly, sepsis and trauma plus organ failures upregulated seven OCRG groups including vesicle, MT fission, mitophagy, sarcoplasmic reticulum–MT, MT fusion, autophagosome–lysosome fusion, and autophagosome/endosome–lysosome fusion, classified as the cell failure-handling OCRGs; (3) suppression of autophagosome–lysosome fusion in endothelial and epithelial cells is required for viral replications, which classify this decreased group as the viral replication-suppressed OCRGs; (4) pro-atherogenic damage-associated molecular patterns (DAMPs) such as oxidized low-density lipoprotein (oxLDL), lipopolysaccharide (LPS), oxidized-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (oxPAPC), and interferons (IFNs) totally upregulated 33 OCRGs in endothelial cells (ECs) including vesicle, MT fission, mitophagy, MT fusion, endoplasmic reticulum (ER)–MT contact, ER– plasma membrane (PM) junction, autophagosome/endosome–lysosome fusion, sarcoplasmic reticulum–MT, autophagosome–endosome/lysosome fusion, and ER–Golgi complex (GC) interaction as the 10 EC-activation/inflammation-promoting OCRG groups; (5) the expression of OCRGs is upregulated more than downregulated in regulatory T cells (Tregs) from the lymph nodes, spleen, peripheral blood, intestine, and brown adipose tissue in comparison with that of CD4⁺CD25⁻ T effector controls; (6) toll-like receptors (TLRs), reactive oxygen species (ROS) regulator nuclear factor erythroid 2-related factor 2 (Nrf2), and inflammasome-activated regulator caspase-1 regulated the expressions of OCRGs in diseases, virus-infected cells, and pro-atherogenic DAMP-treated ECs; (7) OCRG expressions are significantly modulated in all the 28 cancer datasets, and the upregulated OCRGs are correlated with tumor immune infiltrates in some tumors; (8) tumor promoter factor IKK2 and tumor suppressor Tp53 significantly modulate the expressions of OCRGs. …”

DataSheet_1_Alteration in glucocorticoids secretion and metabolism in patients affected by cystic fibrosis.docx by Rafał Podgórski (11606097)

“…Data were obtained from 25 affected patients and 70 sex- and age- matched healthy volunteers. We have shown a general decrease in the activity of enzymes involved in the peripheral metabolism of cortisol, such as 11β-hydroxysteroid dehydrogenase type 2, 5α- and 5β-reductases. …”

DataSheet_2_Alteration in glucocorticoids secretion and metabolism in patients affected by cystic fibrosis.docx by Rafał Podgórski (11606097)

“…Data were obtained from 25 affected patients and 70 sex- and age- matched healthy volunteers. We have shown a general decrease in the activity of enzymes involved in the peripheral metabolism of cortisol, such as 11β-hydroxysteroid dehydrogenase type 2, 5α- and 5β-reductases. …”

Enteroendocrine peptides regulate feeding behavior via controlling intestinal contraction of the silkworm <i>Bombyx mori</i> by Sumihiro Matsumoto (6900524)

“…<i>mori</i> neuropeptide G protein-coupled receptor (BNGR)-A19 and -A22 acted as GSRYamide receptors and BNGR-A5 acted as an additional AT receptor. …”

Bivariate plots summarizing the behavior of the slopes and intercepts across the five levels of sociopolitical complexity, as shown in the panels of Fig 6 and Table 2. by Marcus J. Hamilton (9080089)

This figure shows the results for 200 epochs at each lookback starting from 1 to 500. by Muhammad Muneeb (3244095)

A Limited Screen for Protein Interactions Reveals New Roles for Protein Phosphatase 1 in Cell Cycle Control and Apoptosis by Guillermo Flores-Delgado (8659593)

“…We examined two of these interactions in greater detail in A549 cells. …”

Table_1_Re-Evaluation of the Survival Paradox Between Stage IIB/IIC and Stage IIIA Colon Cancer.xlsx by Hongbo Li (130443)

“…And T1N2a colon cancer had significantly lower 5-year overall survival (OS) rate compared with T2N1 disease (74.7% vs. 57.1%, P = 0.018).…”

Table_1_Early Fractional Amplitude of Low Frequency Fluctuation Can Predict the Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation Treatment for Migraine Without Aura.doc... by Menghan Feng (11655429)

“…Importantly, the decreased fALFF in the bilateral precuneus was positively associated with the reduction in the attack times (r = 0.357, p = 0.005, Bonferroni correction, 0.05/5), whereas the reduced fALFF in the right PoCG was negatively associated with reduced visual analog scale (VAS) scores (r = −0.267, p = 0.039, uncorrected); (3) the SVR model exhibited a good performance for prediction (r = 0.411, p < 0.001),which suggests that these extracted fALFF features could be used as reliable biomarkers to predict the treatment response of taVNS for MWoA patients. …”

Image_1_Early Fractional Amplitude of Low Frequency Fluctuation Can Predict the Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation Treatment for Migraine Without Aura.tif by Menghan Feng (11655429)

“…Importantly, the decreased fALFF in the bilateral precuneus was positively associated with the reduction in the attack times (r = 0.357, p = 0.005, Bonferroni correction, 0.05/5), whereas the reduced fALFF in the right PoCG was negatively associated with reduced visual analog scale (VAS) scores (r = −0.267, p = 0.039, uncorrected); (3) the SVR model exhibited a good performance for prediction (r = 0.411, p < 0.001),which suggests that these extracted fALFF features could be used as reliable biomarkers to predict the treatment response of taVNS for MWoA patients. …”

Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks by Sofia Benfeito (4345591)

“…Although the lipophilic triphenylphosphonium (TPP⁺) cation is widely used to target antioxidants to mitochondria, TPP⁺-based derivatives have shown cytotoxicity in several biological <i>in vitro</i> models. We confirmed that <b>Mito.TPP</b> is cytotoxic to both human neuronal (SH-SY5Y) and hepatic (HepG2) cells, decreasing intracellular adenosine triphosphate (ATP) levels, leading to mitochondrial membrane depolarization and reduced mitochondrial mass after 24 h. …”

Three- and four-hour treatments of M64HCl stimulated prolonged epithelial monolayer wound closure in Caco-2 cells. by Sema Oncel (10152053)

DataSheet_1_Bufei Yishen Formula Restores Th17/Treg Balance and Attenuates Chronic Obstructive Pulmonary Disease via Activation of the Adenosine 2a Receptor.zip by Peng Zhao (128233)

“…In addition, BYF activated the A2aR, increased the levels of p-signal transducer and activator of transcription (STAT)5, and decreased the level of p-STAT3 in Treg and Th17 cells. …”

Tuberculosis exposure results in different heterogeneity of the response, which levels after repeated immunization. by Margherita Coccia (5005985)

Image5_Optogenetic modulation of guanine nucleotide exchange factors of Ras superfamily proteins directly controls cell shape and movement.TIF by Dhiman Sankar Pal (16516836)

Comparison of the MLTD and MDD scores of text before and after hypernym substitution using the GPT-J-6B, Programmatic+AI, and T5 approaches. by Karl Swanson (3580583)

“…<p>A) The GPT-J-6b approach reduced the mean MLTD score from 45.32 to 20.01 (<i>w</i> = 10534.5, <i>p-value</i> = 3.715x10^-31) and mean MDD from 2.90 to 2.48 (<i>w</i> = 54731, <i>p-value</i> = 1.859x10^-11) between text before and after hypernym substitution. …”