COMPARE-MS assay performance by Srinivasan Yegnasubramanian (27577)

“…When 20–100 ng of input DNA are used, COMPARE-MS has a >5000-fold dynamic range, which is ∼500-fold higher than that of methylation-sensitive restriction enzyme used alone and ∼5- to 10-fold higher than that of MBD2-MBD capture used alone. () Plot showing measured output methylated CGIs as determined by COMPARE-MS when decreasing amounts of M.SssI-treated WBC DNA is diluted in 20 ng of untreated WBC genomic DNA. …”

Multiple homologs of 16p12.1 genes contribute to neurodevelopmental defects in <i>Drosophila melanogaster</i> and <i>X</i>. <i>laevis</i>. by Lucilla Pizzo (2735491)

“…All measures were normalized to their respective control injected with the same morpholino amount. Scale bar represents 500 μm. (<b>I</b>) Strong knockdown of <i>mosmo</i> led to decreased axon length in neural tube explants (n = 566, two-tailed student’s t-test, *p = 7.40 ×10⁻¹²). …”