يعرض 81 - 100 نتائج من 23,894 نتيجة بحث عن '(( 51 0 decrease ) OR ( 50 ((ns decrease) OR (((we decrease) OR (a decrease)))) ))', وقت الاستعلام: 0.63s تنقيح النتائج
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    Identification, Synthesis, and Biological Evaluations of Potent Inhibitors Targeting Type I Protein Arginine Methyltransferases حسب Xiao Li (107004)

    منشور في 2022
    "…In this study, we first identified several hit compounds against CARM1 by structure-based virtual screening (IC<sub>50</sub> = 35.51 ± 6.68 to 68.70 ± 8.12 μM) and then carried out chemical structural optimizations, leading to six compounds with significantly improved activities targeting CARM1 (IC<sub>50</sub> = 18 ± 2 to 107 ± 6 nM). …"
  7. 87

    Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant حسب Ittipat Meewan (7455041)

    منشور في 2019
    "…Several drugs targeting the protease have been developed, but drug-resistant mutant strains emerged. Here, we screened a library and synthesized a novel class of small molecules based on a tryptophan derivative scaffold identified as HCV NS3/4A protease inhibitors that are active against both wild type and mutant form of the protease. …"
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