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13061
Table4_Fire, volcanism and climate change: the main factors controlling mercury (Hg) accumulation rates in Tropical Lake Lantoa, Sulawesi, Indonesia (∼16,500–540 cal yr BP).xlsx...
Published 2023“…The Holocene Transition was marked by a decrease in HgAR (µ = 8, 3.50–18.84 μg m<sup>−2</sup> yr<sup>−1</sup>) as humid conditions precluded forest burning, followed by high HgAR (µ = 11.35, 3.30–158.32 μg m<sup>−2</sup> yr<sup>−1</sup>) in the Early Holocene. …”
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13062
The GABAergic system is modulated in <i>Toxoplasma</i>-infected DC to facilitate hypermotility.
Published 2012“…GABA levels were analyzed using a GABA ELISA kit as described in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003051#s4" target="_blank">Materials and Methods</a>. Values represent means (±SEM) from two independent experiments performed in quadruplicate. (*) indicates a significant decrease in GABA production compared to non-infected DC in CM (P<0.002, Mann Whitney U-Test). (**) indicates a significant decrease in GABA production compared to untreated <i>Toxoplasma</i>-infected DC (P<0.008, Mann Whitney U-test). …”
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13063
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13064
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13065
Aucubin slows the development of osteoporosis by inhibiting osteoclast differentiation via the nuclear factor erythroid 2-related factor 2-mediated antioxidation pathway
Published 2021“…<p>Osteoporosis (OP) is a metabolic disease. We have previously demonstrated that aucubin (AU) has anti-OP effects that are due to its promotion of the formation of osteoblasts.…”
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13066
Modulation of PIP<sub>2</sub> levels by PLC activity in INS-1 and RyR2<sup>KO</sup> cells.
Published 2023“…INS-1 cells: n = 1294; RyR2<sup>KO</sup> cells: n = 1377; IRBIT<sup>KO</sup> cells n = 1650. Data are shown as mean ±SD. One-way ANOVA with Dunnett’s multiple comparisons test. …”
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13067
Ablation of <i>PC3/Tis21</i> impairs terminal differentiation of 1- to 5-day-old adult-generated dentate gyrus progenitor cells.
Published 2009“…Scale bar, 50 µm; 27 µm in the inset.</p>…”
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13068
ERR2/3 promote a gamma motor neuron-like biophysical signature in chick through transcriptional activation.
Published 2022“…No decrease in rheobase upon ERR2:EnR (<i>n</i> = 17) transfection. …”
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13069
PLK2i treatment of OHSCs does not affect generation of pS129 positive aggregates, but reduces the nuclear pS129 intensity.
Published 2021“…Scale bars = 20 μm. b) Quantification of the amount of aggregation (aggregate area normalized to tissue area), defined by MJF-14 staining (p-value = 0.09). c-d) Quantification of the mean fluorescence intensity of α-syn aggregates detected with MJF-14 (c, p-value = 0.712) and aggregate-specific pS129 that overlaps with MJF-14 (d, p-value = 0.214). e) Quantification of nuclear (non-aggregate related) pS129, illustrating a significant decrease in mean fluorescence intensity following PLK2i-treatment (p-value = 0.0087). f) Relative ratio of aggregate-specific pS129/nuclear pS129 in PFF-injected slices shows an increase of ratio of the signals of aggregates/background following PLK2i treatment, due to reduction of the non-aggregate-related nuclear pS129-signal (p-value = 0.009). …”
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13070
Inhibition of autocrine TGFβ2 signaling prevents reduction of capillary morphogenesis by miR-30b.
Published 2017“…<p>(A) HUVECs were serum starved overnight in MCDB 131 with 0.5% FBS and stimulated with VEGF (50 ng/ml) in the presence or absence of Avastin (1 μg/ml) for 24 hours. …”
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13071
Healthcare resource use and direct costs in severe aplastic anemia (SAA) patients before and after treatment with eltrombopag
Published 2019“…</p> <p><b>Results:</b> The average patient age was 50.8 (<i>SD</i> = 20.6) years old, predominantly female (<i>n</i> = 43, 52.4%), and had a mean CCI at baseline of 1.1 (<i>SD</i> = 1.7). …”
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13072
I-R-Polar-Negative-0902
Published 2023“…In order to maintain blood flow from both the iliac arteries and ovaries, the uterine vessels were ligated in the midsection of each uterine horn to increase the likelihood of fetal survival and decrease the probability of a partial miscarriage. …”
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13073
Table_1_Mitigating Nitrogen Emissions From Dairy Farming Systems in China.DOCX
Published 2020“…N losses from manure management are 56.8–59.5% of total N excretion, of which approximately 50% is emitted as NH<sub>3</sub>. …”
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13074
Supplementary Material for: Real-world effectiveness of piperacillin/tazobactam with and without linezolid for spontaneous bacterial peritonitis
Published 2022“…Results: In the first cohort, 100 SBP episodes were empirically treated with TZP+LZD combination therapy (n=50) or PTZ monotherapy (n=50). Treatment failure was recorded in 48% with TZP monotherapy compared with 16% with TZP+LZD combination therapy (P=0.001), and this difference persisted after stratification for community-acquired versus hospital-acquired SBP. …”
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13075
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13076
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13077
Prenatal Treatment of Mosaic Mice (Atp7a mo-ms) Mouse Model for Menkes Disease, with Copper Combined by Dimethyldithiocarbamate (DMDTC)
Published 2012“…The mouse model, <em>mosaic Atp7a </em><b><em><sup>mo-ms</sup></em></b> recapitulates the Menkes phenotype and die about 15.75±1.5 days of age. In the present study we found that prenatal treatment of <em>mosaic</em> murine fetuses throughout gestation days 7, 11, 15 and 18 with a combination of CuCl<sub>2</sub> (50 mg/kg) and dimethyldithiocarbamate (DMDTC) (280 mg/kg) leads to an increase in survival to about 76±25.3 days, whereas treatment with CuCl<sub>2</sub> alone (50 mg/kg) only leads to survival for about 21 days ±5 days. …”
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13078
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13079
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13080
Image 3_Evaluation of the cytotoxicity and antibacterial activity of a synthetic tunicamycin derivative against Mycobacterium avium complex.jpeg
Published 2025“…The concentrations of the drug that produce 50% of inhibition (IC<sub>50</sub>) in each of these three cell types was lower than the MIC for Map. …”