DataSheet1_Unraveling the therapeutic mechanisms of dichloroacetic acid in lung cancer through integrated multi-omics approaches: metabolomics and transcriptomics.CSV by Malong Feng (16076690)

“…<p>Objective: The aim of this study was to investigate the molecular mechanisms underlying the therapeutic effects of dichloroacetic acid (DCA) in lung cancer by integrating multi-omics approaches, as the current understanding of DCA’s role in cancer treatment remains insufficiently elucidated.</p><p>Methods: We conducted a comprehensive analysis of publicly available RNA-seq and metabolomic datasets and established a subcutaneous xenograft model of lung cancer in BALB/c nude mice (n = 5 per group) treated with DCA (50 mg/kg, administered via intraperitoneal injection). …”

A 1,2,3-Triazole Derivative of Quinazoline Exhibits Antitumor Activity by Tethering RNF168 to SQSTM1/P62 by Fu-Cheng Wang (14059045)

“…We found that compound <b>5a</b> was the most cytotoxic to HCT-116 cells (IC₅₀, 0.36 μM). …”

Factors associated with the <i>SS</i> Positives. by Anuradha Rajamanickam (5278013)

“…<div><p><i>Strongyloides stercoralis (Ss)</i> is a parasitic infection affecting 50–100 million people globally, with significant immune and metabolic consequences, particularly in immunocompromised individuals. …”

Image_1_Poly I:C Activated Microglia Disrupt Perineuronal Nets and Modulate Synaptic Balance in Primary Hippocampal Neurons in vitro.TIF by David Wegrzyn (10180829)

“…Based on this knowledge, we analyzed the impact of activated microglia on hippocampal neuronal networks in vitro. …”

Table_1_Dual targeting of glutamine and serine metabolism in acute myeloid leukemia.xlsx by Kanwal M. Hameed (18386853)

“…Inhibition of serine biosynthesis through CRISPR-Cas9-mediated knockout of PHGDH resulted in a ~250-fold reduction in the half-maximal inhibitory concentration (IC₅₀) for Rylaze, indicating heightened sensitivity to crisantaspase therapy. …”

A Mixed-Method Approach for Quantifying Illegal Fishing and Its Impact on an Endangered Fish Species by Christopher M. Free (463223)

“…Interviewed herders and rangers generally agree that fish population sizes are decreasing but are divided on the causes and solutions. …”

DataSheet_1_Diurnal decline in photosynthesis and stomatal conductance in several tropical species.docx by Wachira Suwannarut (17273905)

“…We then examined in more detail the irradiance-induced kinetics of gas exchange in a C₃ and C₄ crop species each, namely fig (Ficus carica) and sugarcane (Saccharum officinarum). …”

Supplementary Material for: Clinical Features and Long-Term Outcomes in 109 Pediatric Generalized Pustular Psoriasis by figshare admin karger (2628495)

“…Flare duration was categorized as ≤4 weeks or >4 weeks. In addition, we investigated the factors associated with flare frequency in PGPP patients. …”

Proteomic Analysis Reveals Novel Molecules Involved in Insulin Signaling Pathway by Yiguo Wang (2644723)

“…Furthermore, insulin was able to decrease CASK nuclear location, as well as down-regulate the expression of CASK targeted genes. …”

Fumarate Reductase Activity Maintains an Energized Membrane in Anaerobic <em>Mycobacterium tuberculosis</em> by Shinya Watanabe (3092)

“…A drop in dissolved oxygen concentration from 50 mmHg to 0.42 mmHg led to a 2.3 fold decrease in intracellular ATP levels with an almost 70-fold increase in the ratio of NADH/NAD⁺. …”

Video_1_Poly I:C Activated Microglia Disrupt Perineuronal Nets and Modulate Synaptic Balance in Primary Hippocampal Neurons in vitro.MP4 by David Wegrzyn (10180829)

“…Based on this knowledge, we analyzed the impact of activated microglia on hippocampal neuronal networks in vitro. …”

Electrical Conductivity of Subsurface Ocean Analogue Solutions from Molecular Dynamics Simulations by Catherine A. Psarakis (18787118)

“…The <i>Europa Clipper</i> mission will conduct approximately 50 flybys of Jupiter’s moon Europa, returning a detailed portrait of its interior from the synthesis of data from its instrument suite. …”

Changes in Patch Features May Exacerbate or Compensate for the Effect of Habitat Loss on Forest Bird Populations by Ainhoa Magrach (124536)

“…Satellite image analyses revealed that, from 1985 to 2008, forested area decreased by 8.8% and the remaining forest fragments became 16% smaller, 58–73% more isolated and 11–50% more regular. …”

Change in domestic food demand (kcal/cap/day) in 2050 for the different yield scenarios and the 'High-Input' pathway by H Valin (557174)

“…Our results confirm that yield increase could mitigate some agriculture-related emissions growth over the next decades. Closing yield gaps by 50% for crops and 25% for livestock by 2050 would decrease agriculture and land use change emissions by 8% overall, and by 12% per calorie produced. …”

Table_1_Is COVID-19 Keeping us Up at Night? Stress, Anxiety, and Sleep Among Adult Twins.pdf by Siny Tsang (3705889)

“…About half of participants reported no change in sleep amount (50.1%) or sleep quality (55.6%). Approximately one-third of the participants had increased amount of sleep (29.8%), and 32.9% reported a decrease in sleep quality. …”

Image2_Visualizing Cancer Cell Metabolic Dynamics Regulated With Aromatic Amino Acids Using DO-SRS and 2PEF Microscopy.TIFF by Pegah Bagheri (11838740)

“…In contrast, these cells exhibited a decrease in the protein synthesis rate by ∼10% under these AAA treatments. …”

An <i>in-silico</i> analysis to identify structural, functional and regulatory role of SNPs in <i>hMRE11</i> by Bhoomi Tarapara (11977197)

“…<p>Meiotic recombination 11 (<i>MRE11</i>) is a component of the tri-molecular <i>MRE11</i>-RAD50-NBS1 (MRN) complex, which functions as an exonuclease and endonuclease which is involved in identifying, signalling, protecting and repairing double-strand breaks in DNA (DSBs). …”

Proteomic Analysis Reveals Novel Molecules Involved in Insulin Signaling Pathway by Yiguo Wang (2644723)

“…Furthermore, insulin was able to decrease CASK nuclear location, as well as down-regulate the expression of CASK targeted genes. …”

DataSheet_1_Dual targeting of glutamine and serine metabolism in acute myeloid leukemia.pdf by Kanwal M. Hameed (18386853)

“…Inhibition of serine biosynthesis through CRISPR-Cas9-mediated knockout of PHGDH resulted in a ~250-fold reduction in the half-maximal inhibitory concentration (IC₅₀) for Rylaze, indicating heightened sensitivity to crisantaspase therapy. …”

Accidental pharmacological poisonings in young children: population-based study in three settings by Jane C. Bell (4767096)

“…There are limited data assessing concurrent management of poisonings across all three settings. We aimed to describe accidental pharmacological poisonings in young children across our Poisons Information Centre (PIC), EDs and hospitals.…”