Pyrvinium inhibits Wnt signaling. by Sarika Saraswati (236578)

“…<p>(<b>A</b>) Pyrvinium inhibits TOPflash activation with an EC₅₀ of ∼10 nM in contrast to the structurally related compound VU-WS211. …”

SS- and AGEs-induced simultaneous increases in proliferation and apoptosis of VSMCs are closely associated with selective activation of three members the MAPK subfamily. by Suning Ping (172755)

“…<p>The cultured quiescent VSMCs were pretreated with DMSO, ERK inhibitor PD98059 (50 μM), JNK inhibitor SP600125 (20 μM), and p38MAPK inhibitor SB202190 (20 μM) for 1 h and then treated with SS and/or AGEs for 1 h and continually cultured for 23 h. …”

Nuclear Quantum Effects in Sodium Hydroxide Solutions from Neural Network Molecular Dynamics Simulations by Matti Hellström (1886893)

“…We find that NQEs have a very small impact on the solvation structure around Na⁺, slightly strengthen the water–water and water–hydroxide hydrogen bonds, and lower the peak positions in the power spectra for the HOH bending and OH stretching modes by about 50 and 100 cm^–1, respectively. Moreover, NQEs significantly lower the proton transfer barriers, thus increasing the proton transfer rates, resulting in an increase of the diffusion coefficient in particular of OH^–, as well as a decrease of the mean residence time of molecules in the first hydration shell around Na⁺ at high NaOH concentrations.…”

Transcriptional downregulation of Bcl-2 is critical to mediate PMC-A induced apoptosis. by Cagri Bodur (282762)

“…The results from at least 3 independent experiments were shown as means ± SD. Difference of mean values between mock and Bcl-2-transfected cells were tested using paired student’s t-test; <b>**</b>P<0.01. …”

Data_Sheet_2_An Item-Level Analysis for Detecting Faking on Personality Tests: Appropriateness of Ideal Point Item Response Theory Models.CSV by Jie Liu (15128)

“…The item-level analysis revealed both conscientiousness items (18.8%) and neuroticism items (50.0%) appeared significant shifts on item parameters, suggesting that response pattern changed from honest to faking conditions. …”

Effects of adenosine receptor-specific antagonists on responses to hypoxia at E9.5 and E12.5. by Daniela L. Buscariollo (140729)

“…In contrast, at both ages DPCPX elevated heart rates above vehicle levels in normoxic conditions and inhibited hypoxia-mediated heart rate decrease below baseline (A and B). Although E12.5 heart rates did not fall below baseline in hypoxia, heart rates decreased compared to levels following DPCPX addition in room air (p<0.01 and p<0.0001, for t = 50 min and t = 65 min compared to t = 20 min, respectively, B). …”

Average player As’ transfers across rounds and resulting earnings. by Christoph Eisenegger (430948)

“…Vertical lines indicate standard errors of the mean.</p>…”

Physiological and transcriptomic data for <i>sdc</i>, <i>dc</i> and <i>sdc/dc</i> mutants. by Diego H. Sanchez (230286)

“…Right: Relative mean aerial biomass as percentage of controls obtained from the data shown on the left, denoting a decrease of at least 30% in relative biomass after treatment of genetic backgrounds harboring the <i>sdc</i> mutation. …”

The presynaptic changes in the inhibitory synaptic currents in the neocortex evaluated by PPR. by Ulyana Lalo (506296)

“…(A–C) Graphs show the representative IPSCs (average of 25 traces) evoked with a 50 ms interval in control and during application of 10 µM TFLLR. …”

Disease course of Chronic Relapsing Inflammatory Optic Neuropathy (CRION) in a single care center by Luis Enrique MOLINA-CARRIÓN (12687286)

“…Visual acuity was recovered in 50%, did not improve in 33%, and recovered incompletely in 17%. …”

Spatial-temporal variation in litterfall in seasonally dry tropical forests in Northeastern Brazil by V. F. P. Araújo (7141901)

“…Eight sampling points were randomly chosen at each site, and two 1 m2 collectors were installed 50 m apart from each other. The collected material was sorted, dried and weighed. …”

Cartilage and subchondral bone degeneration scores at 7 and 12 wks after the start of the experiment. by Junya Sakamoto (4286575)

“…In b and c, <i>Black arrowheads</i> indicate the decrease of the staining of cartilage matrix in the superficial layer of articular cartilage. …”

Activity of miR-124 and miR-23a in NSC-derived neurons and astrocytes. by Annalisa Lattanzi (427545)

“…Arrowheads indicate GFP⁺marker⁺ (miR^−/low) cells, arrows indicate GFP⁻marker⁺(miR^+/high) cells. Data are the mean ± SEM; n = 3 experiments, 1–3 coverlips/antigen/experiment. …”

Transmembrane signaling in cell-derived plasma membrane vesicles. by Luigino Grasso (208932)

“…(E) A dose-dependent increase of the FRET yields <i>EC₅₀</i> = 100±11 nM; shown are averages and standard deviations of the mean of nine titration experiments each performed on different, individual vesicles.…”

Dataset for penetration resistance, aggregate stabiltiy and infiltration of biocrusts of the Caatinga, NE Brazil by Michelle Szyja (14124273)

“…., 2023: Biological soil crusts decrease infiltration but increase erosion resistance in a human-disturbed tropical dry forest. …”

Ex vivo fitness, CTL escape phenotype and sequence evolution of <i>gag</i> p24 CTL escape mutants. by Ryan M. Troyer (265934)

“…EC₅₀ values>10 were considered to indicate escape. …”

DataSheet_1_Associations of chest X-ray trajectories, smoking, and the risk of lung cancer in two population-based cohort studies.docx by Ya Liu (205636)

“…CXR_LP was associated with decreased LC risk. However, even smokers lost their positive CXR, and the increased risks of LC incidence and mortality did not decrease to non-significant level. …”

The GABAergic system is modulated in <i>Toxoplasma</i>-infected DC to facilitate hypermotility. by Jonas M. Fuks (113543)

“…GABA levels were analyzed using a GABA ELISA kit as described in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003051#s4" target="_blank">Materials and Methods</a>. Values represent means (±SEM) from two independent experiments performed in quadruplicate. (*) indicates a significant decrease in GABA production compared to non-infected DC in CM (P<0.002, Mann Whitney U-Test). (**) indicates a significant decrease in GABA production compared to untreated <i>Toxoplasma</i>-infected DC (P<0.008, Mann Whitney U-test). …”

Modulation of PIP₂ levels by PLC activity in INS-1 and RyR2^KO cells. by Kyle E. Harvey (4375987)

“…INS-1 cells: n = 1294; RyR2^KO cells: n = 1377; IRBIT^KO cells n = 1650. Data are shown as mean ±SD. One-way ANOVA with Dunnett’s multiple comparisons test. …”

Ablation of <i>PC3/Tis21</i> impairs terminal differentiation of 1- to 5-day-old adult-generated dentate gyrus progenitor cells. by Stefano Farioli-Vecchioli (256006)

“…Scale bar, 50 µm; 27 µm in the inset.</p>…”