Effect of RORα deficiency on PEPCK expression. by Hiroshi Matsuoka (797627)

“…<p>Suppression of endogenous RORα by siRNA significantly decreased PEPCK mRNA in HepG2 cells. HepG2 cells were transfected with 50 nM siRNA, and analyzed by qRT-PCR to measure expression of RORα and PEPCK. siRNAs that target sequences around 258 bp (siRORa-258, dotted bars) and 1388 bp (siRORa-1388, hatched bars) downstream of the RORα start codon decreased RORα and PEPCK mRNA levels, while a scrambled siRNA (siRORa-mt, closed bars) did not. siRNA against green fluorescent protein was used as negative control (siGFP, open bars). …”

Data_Sheet_1_Extreme Low-Temperature Stress Affects Nutritional Quality of Amino Acids in Rice.docx by Min Kang (287002)

Image 1_Modulating effects of Phellinus linteus polysaccharides on antioxidant capacity, immune function, intestinal function and microbiota in lipopolysaccharide-challenged broile... by Yang Li (7082)

The Effect of the Sloping Land Conversion Programme on Farm Household Productivity in Rural China by Zhen Liu (74646)

Evaluation of respiratory mechanics in pregnant women by Anaelisa Venâncio Antunes Pinto (12816107)

Supplementary Material for: The Impact of the SARS-CoV-2 (COVID-19) Pandemic on Gastroenterology Training by Pisani A. (10713897)

“…Later, when the number of COVID-19-related infections decreased across Europe, the above modalities returned to normal for <50% of the trainees. …”

Epigenome-wide association studies of occupational exposure to benzene and formaldehyde by Rachael V. Phillips (6880574)

“…In the benzene EWAS, we found genome-wide significant alterations, i.e., FWER-controlled <i>P</i>-values <0.05, in the mean and variance of methylation at 22 and 318 CpG sites, respectively, and in mean methylation of a large genomic region. …”

Parameter estimates from 2-regime models reveal varying impacts of latitude. by Jonathan P. Drury (3251745)

“…For (a–c), each point represents the mean across clade-by-trait fits to stochastic maps of biogeography and of tropical/temperate membership (for all families with at least 50 species), and for (d), each point represents the mean across stochastic maps of tropical/temperate membership maximum (see <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001270#pbio.3001270.s037" target="_blank">S4</a> and <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3001270#pbio.3001270.s038" target="_blank">S5</a> Datas). …”

Competence development during microaerobic growth. by Nora-Johanna Krüger (520283)

“…At t2 (~ t0 + 6–8 hours) upon switch into competent state (50.6 ± 15.6% of cells with active outer membrane DNA uptake) cells exhibited a mean OD₆₀₀ of 0.7 ± 0.11. …”

IFT mutant fish develop and maintain a functional BRB. by Lana M. Pollock (9193262)

“…(E) As an example of BRB breakdown, <i>Tg(l-fabp</i>:<i>DBP-EGFP;flk1</i>:<i>mCherry)</i> embryos were treated with 0.15 μM BMS493, an inhibitor of retinoic acid signaling, from 2 dpf until 7 dpf. Scale bars = 50 μm. No increase in the Extravascular Space Mean Intensity was observed in the eyes of 6 dpf <i>ift172</i> (F), <i>ift57</i> (G), or <i>ift88</i> (H) fish compared to their wild-type siblings, confirming that the IFT mutant fish do not exhibit increased leakage of DBP-EGFP outside of their hyaloid vessels. …”

Inhibition of PI3K/Akt activity reduces phosphorylation of GSK3β while increases HB9 motor neuron differentiation. by Luis Ojeda (208583)

“…In both ELL and FL primed groups, all inhibitors decreased GSK3β Ser9 phosphorylation as compared with DMSO controls (mean ± SEM; n = 3; * p<0.05, ** p<0.01, *** p<0.001, one-way ANOVA). …”

MSC^hUCB1 express neural specific markers suggesting neural differentiation. by Murni Tio (197880)

“…The four P-TH isoforms are of sizes between 50.7 kDa and 90 kDa. Note that the different P- TH isoforms (isoforms 1, 3 and isoforms 2, 3) are differentially regulated (day 3 and day 5 post-induction, respectively). …”

An Endogenous Aryl Hydrocarbon Receptor Ligand Induces Preeclampsia-like Phenotypes in Rats by Ying-jie Zhao (12873793)

“…ITE increased proteinuria by 50% and decreased uteroplacental blood flow by 26%. …”

Polysome-associated cellular mRNAs are longer and more AU-rich. by William J. Neidermyer Jr. (6866672)

“…***p< 2.2 x 10⁻¹⁶; **p< 5.0 x 10⁻⁵; *p< 0.05; all others p> 0.05 as determined by the Wilcoxon rank sum test compared to mRNAs with relative abundance levels within the 95% confidence interval of the mean. …”

Robotic Mitral Valve Surgey Combined with Left Atrial Reduction and Ablation Procedures by Unal Aydin (6043799)

“…Postoperatively, in hospital evaluation LAVI decreased to 48.01±4.91 mL/m2 (P=0.008), EF to 50.63±10.13% (P>0.05), and PAP to 39.02±3.11 mmHg (P=0.012). …”

Table_1_Favorable Effects of Tacrolimus Monotherapy on Myasthenia Gravis Patients.DOCX by Zhirong Fan (9566711)

“…QMG scores significantly decreased at 6 and 12 months, with mean differences and 95% CIs of −4.67(−6.88, −2.45) and −5.77 (−7.55, −4.00), respectively. …”

Table_1_The Efficacy and Medium to Long-Term Follow-Up of Transcatheter Retrograde Closure of Perimembranous Ventricular Septal Defects via the Femoral Artery With Amplatzer Duct O... by Diandong Jiang (6943835)

“…The average age was 4.03 ± 1.84 years and the mean weight was 17.50 ± 5.58 kg. The mean diameter of the defects was 2.58 ± 0.63 mm. …”

(A) Representative mEPSC traces from WT and hippocampal neurons in the presence of 10 μM bicuculline (Bic) and 1 μM tetrodotoxin (TTX) by Xiao-Wei Chen (58404)

“…Inset shows that the lack of dysbindin notably decreased the mean frequency of mEPSCs. (D) Histograms display quantitative analysis of HHD, RT, and charge of mEPSCs, showing that the lack of dysbindin slows the kinetics and increases the charge of single vesicle release. …”

Dependency of Cl⁻ accumulation on the site of synaptic input and KCC2 level. by Nicolas Doyon (344567)

“…Synaptic background activity was the same as in <b>B</b>. Mean IPSC was measured at a “test” synapse activated at 40 Hz for 200 ms every second over 50 s of simulated time. …”

Influence of COS on the activation of NF-κB in retina and RGC-5 cells. by I-Mo Fang (470460)

“…Data were expressed as mean ± SD. (†<i>P</i> < 0.05 compared with PQ; ‡<i>P</i> < 0.05 compared with normal control by Student’s t-test; N=3 in each group).…”