Data Sheet 1_Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systemat... by Yuhua Jiang (10300159)

“…</p>Conclusions<p>The combination of PCSK9 inhibitors with robust statins like rosuvastatin and atorvastatin markedly decreases LDL-C levels in patients with hyperlipidemia when compared to placebo or monotherapy. …”

DataSheet1_Computational design of custom therapeutic cells to correct failing human cardiomyocytes.pdf by Andrew Tieu (14441499)

“…Using a genetic algorithm-based optimization approach, candidate cells were accepted if a root mean square error (RMSE) of less than 50% relative to healthy hCM was achieved for both action potential and calcium transient waveforms for the cell-treated HF cardiomyocyte, normalized to the untreated HF cardiomyocyte.…”

Neuronal responses to visual stimuli in the proposed microcircuit model with different excitatory/inhibitory (E/I) ratios caused by a change in parvalbumin (PV) inhibitory interneu... by Nobuhiko Wagatsuma (494052)

“…<p>Note that the total number of model neurons in the network remained consistent, irrespective of E/I ratio. <b><i>A.</i></b> Mean population firing rates of Pyr (black triangles in first panel from the left), PV (gray circles in the second panel), somatostatin (SOM; gray pentagons in the third panel), and vasoactive intestinal polypeptide (VIP; gray diamonds in the fourth panel) populations as a function of E/I ratios. …”

Table_1_Longitudinal Changes in the Composition of the Penile Microbiome Are Associated With Circumcision Status, HIV and HSV-2 Status, Sexual Practices, and Female Partner Microbi... by Supriya D. Mehta (7919309)

“…Across varying analytic approaches, 50%–60% of men had stable penile microbiome compositions. …”

Characterisation of conidial length and ascospore production in <i>ΔFgknr4</i> and complemented strains. by Erika Kroll (20537020)

“…<p><b>A.</b> Decreased conidial length observed in <i>ΔFgknr4</i>. …”

Table1_Reduction in broad-spectrum antimicrobial prescriptions by primary care pediatricians following a multifaceted antimicrobial stewardship program.docx by F Pagano (14336988)

“…The prescription rates of Amoxicillin-Clavulanate (50.25 to 14.21; R²= 0.983, p = 0.001) and third generation Cephalosporins (28.43 to 5.43; R²= 0.995, p < 0.01) significantly decreased; we didn't find significant modifications in the prescription rates of Amoxicillin and Quinolones; finally, we observed a trend toward reduction in the prescription of Macrolides. …”

Lhx1 controls the differential expression of Dab1 in LMC neurons. by Elena Palmesino (179868)

“…Scale bar: 66 µm (A–H), 50 µm (I–N).</p>…”

Rapamycin increases autophagy in brains of PDAPP mice. by Patricia Spilman (365919)

Source-specific carbon dioxide production and acetoclastic methanogenesis upon anaerobic degradation of dissolved organic matter by Yongqiang Zhou (11551027)

“…Isotope fractionation (α_C) decreased from 1.05–1.10 on day 0 to 1.03–1.04 on day 56, and δ¹³C-CH₄ rose to –40‰, suggesting immediate acetoclastic methanogenesis. …”

Table 1_Global burden of anemia attributed to chronic kidney disease: prevalence, years lived with disability, and predictions to 2035 (Global burden of disease 2021).docx by Wenshuai Zheng (21641225)

“…Background<p>As a common complication of chronic kidney disease (CKD), anemia is associated with increased mortality and reduced quality of life. …”

Individual cost data. by Jamal Atfeh (21212547)

“…</p><p>Results</p><p>Two comparative retrospective cohort studies were retrieved from the literature review. They suggested a decreased incidence of wound healing complications with iNPWT compared to standard dressings, although no difference was found in the PICO-PTC study. …”

Data_Sheet_1_Leptin Protects Against the Development and Expression of Cocaine Addiction-Like Behavior in Heterogeneous Stock Rats.pdf by Lieselot L. G. Carrette (12198218)

“…It has been hypothesized that feeding hormones like leptin play a role in this process. Preclinical studies have shown a mutually inhibitory relationship between leptin and cocaine, with leptin also decreasing the rewarding effects of cocaine intake. …”

Efp siRNAs suppress the migration of endometrial cancer cells. by Wataru Sato (149080)

Syncytiotrophoblast extracellular vesicles impair rat uterine vascular function via the lectin-like oxidized LDL receptor-1 by Floor Spaans (307972)

“…This was prevented by co-incubation of STBEV-incubated arteries with LOX-1 blocking antibodies (MCh E_max: 78.8±4.3%, p<0.05). Pre-incubation of the vessels with a nitric oxide synthase inhibitor (L-NAME) demonstrated that the STBEV-induced impairment in vasodilation was due to decreased nitric oxide contribution (ΔAUC 12.2±11.7 in STBEV-arteries vs. 86.5±20 in controls, p<0.05), which was abolished by LOX-1 blocking antibody (ΔAUC 98.9±17, p<0.05). …”

Structural analysis of wild type and mutated variants of CXCR4. by Bonoshree Sarkar (20469331)

“…<p>(a) G55 in the wild-type protein and Val55 in mutated protein forms 2 H-bonds with Thr51 and Val59; (b) His79 in wild type protein engages in 4 H-bonds with Lys75, Tyr76, Val82, and Ala83, while the mutated Pro79 forms only 1 H-bond with Ala83; (c) H-bond number again changed with Leu80 (with Tyr76, Ala83, and Asn84) mutation from 3 to 2 with Pro80 (with Ala83 and Ans84); meanwhile, (d) H-bond number decreased from 4 to 2 in the mutated version of H113 (Cys109, Cys109, Thr117, Asp171) to P113 (Tyr116, Thr117); (e) P299 and L299 both create 2 H-bond but with different amino acids, P299 with Tyr302, Cys295, and L299 with Tyr302, Ala303, respectively. …”

Olive Oil Consumption and Age-Related Macular Degeneration: The Alienor Study by Audrey Cougnard-Grégoire (532085)

“…After adjustment for potential confounders, regular use of olive oil was significantly associated with a decreased risk of late AMD (odds ratio [OR] = 0.44, 95% confidence interval [CI]: 0.21;0.91). …”

Review and Analysis of Publication Trends over Three Decades in Three High Impact Medicine Journals by Alexander Ivanov (257155)

“…Total number of published studies decreased by 17% from 1988 to 2008. Over 20 year period, the proportion of prospective randomized trials increased from 22 to 46% (p < 0.0001); whereas the proportion of prospective non-randomized trials decreased from 59% to 27% (p < 0.001). …”

The global disability-adjusted life years (DALYs) for asthma attributable to nitrogen dioxide pollution from 1990 to 2021 and predicted the trends from 2022 to 2050 by Yaping Feng (427666)

“…In 2021, SEV and ASDALYs in Lebanon were 84.35 [95%<i>UI</i>: 0 to 100] and 19.73 [95%<i>UI</i>: −19.51 to 59.84], respectively. …”

DataSheet_1_Chinese Herbal Medicine (MaZiRenWan) Improves Bowel Movement in Functional Constipation Through Down-Regulating Oleamide.docx by Tao Huang (110613)

“…Changes in levels of circulating oleamide and its derivatives negatively correlate with improvement in complete spontaneous bowel movement (CSBM) in the MZRW group (Pearson r = -0.59, p = 0.00057). The same did not hold true for either Senna or placebo groups. …”

Anxiety, depression and quality of life in acute high risk cardiac disease patients eligible for wearable cardioverter defibrillator: Results from the prospective multicenter CRED-... by Michael Weiss (4759833)

“…</p><p>Results</p><p>123 patients (mean [SD] age 59 [± 14] years, 75% male) were included, 85 (69%) of whom received a WCD. …”