Showing 321 - 340 results of 14,065 for search '(( 59 ((0 decrease) OR (a decrease)) ) OR ( 50 ((ns decrease) OR (we decrease)) ))', query time: 0.58s Refine Results
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    Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver. by Nicole K. Polinski (10947787)

    Published 2021
    “…(A-B) GCase levels as assessed by the CBE/4-MU method are significantly decreased in the het <i>GBA1</i> D409V KI mice at 5 months of age in both brain (A) and liver (B). …”
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    Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity by Xiao-Meng Liu (778197)

    Published 2023
    “…Among them, compound <b>10</b> exhibited a 118-fold enhancement in the IC<sub>50</sub> value compared to cisplatin and low toxicity to normal cells. …”
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    GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age. by Nicole K. Polinski (10947787)

    Published 2021
    “…GCase activity measured by 4-MU in brain (A) measured as follows: WT 4mo 27.63±0.68, HOM 4mo 2.53±0.07, WT 8mo 27.65±0.69, HOM 8mo 3.01±0.20, WT 12 mo 27.49±0.46, HOM 12mo 3.15±0.26. …”
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    <i>pqn-59</i> depletion corrects the reduction of mature <i>lin-4</i> and <i>let-7</i> miRNA levels observed in <i>alg-1(0)</i> mutants and has little effect on the expression of c... by Colleen Carlston (11740725)

    Published 2021
    “…<p><b>(A)</b> Taqman analysis of <i>lin-4</i> and <i>let-7</i> miRNAs isolated from wild-type or <i>alg-1(gk214)</i> animals subjected to control or <i>pqn-59</i> dsRNAs. …”
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    Flowchart of patients. by Seydou Goro (17847203)

    Published 2024
    “…Using the number of competitors per distance method, our study showed that a “highly competitive” and “moderately competitive” markets decreased mortality by 31% [OR: 0.69 (0.59, 0.80); p<0.001] and by 12% respectively [OR: 0.88 (0.79, 0.99); p<0.03], compared to the “non-competitive” market. …”
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    Optical coherence tomography findings. by Eisuke Usui (12111855)

    Published 2024
    “…After PCI, hDPV significantly increased from 55.6 cm/s to 69.5 cm/s (P<0.01), with a median %hDPV increase of 27.2 (6.32–59.1) %, while %hDPV decreased in 20 (19.4%) patients. …”
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    S1 Data - by Eisuke Usui (12111855)

    Published 2024
    “…After PCI, hDPV significantly increased from 55.6 cm/s to 69.5 cm/s (P<0.01), with a median %hDPV increase of 27.2 (6.32–59.1) %, while %hDPV decreased in 20 (19.4%) patients. …”
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    Clinical demographics and angiographic findings. by Eisuke Usui (12111855)

    Published 2024
    “…After PCI, hDPV significantly increased from 55.6 cm/s to 69.5 cm/s (P<0.01), with a median %hDPV increase of 27.2 (6.32–59.1) %, while %hDPV decreased in 20 (19.4%) patients. …”
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    Physiological parameters. by Eisuke Usui (12111855)

    Published 2024
    “…After PCI, hDPV significantly increased from 55.6 cm/s to 69.5 cm/s (P<0.01), with a median %hDPV increase of 27.2 (6.32–59.1) %, while %hDPV decreased in 20 (19.4%) patients. …”
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    Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant by Ittipat Meewan (7455041)

    Published 2019
    “…Several drugs targeting the protease have been developed, but drug-resistant mutant strains emerged. Here, we screened a library and synthesized a novel class of small molecules based on a tryptophan derivative scaffold identified as HCV NS3/4A protease inhibitors that are active against both wild type and mutant form of the protease. …”