Datasheet1_Low total cholesterol predicts early death in children with hemophagocytic lymphohistiocytosis.zip by Li Xiao (307908)

“…The observed 30-day mortality rate was 19.05% (64/336, 17 were lost to follow-up) and Kaplan-Meier-estimated 3-year survival rate was 61.67% (95% CI, 56.27%–67.59%). DNA-targeted sequencing of HLH-related genes was performed in 173 (49.0%, 173/353) patients (not all patients with suspected pHLH underwent genetic testing), and 29 patients were diagnosed with genetically confirmed pHLH. …”

Table1_Low total cholesterol predicts early death in children with hemophagocytic lymphohistiocytosis.xlsx by Li Xiao (307908)

“…The observed 30-day mortality rate was 19.05% (64/336, 17 were lost to follow-up) and Kaplan-Meier-estimated 3-year survival rate was 61.67% (95% CI, 56.27%–67.59%). DNA-targeted sequencing of HLH-related genes was performed in 173 (49.0%, 173/353) patients (not all patients with suspected pHLH underwent genetic testing), and 29 patients were diagnosed with genetically confirmed pHLH. …”

Predictive value of the characteristics of intraretinal cystoid spaces on early response to antivascular endothelial growth factor treatment in patients with cystoid diabetic macul... by Eyyup Karahan (5762135)

“…The disrupted ellipsoid zone was present in 13 (59.0%) of 22 eyes with outer nuclear layer cysts, whereas in only 1 of 14 eyes (7.1%) without outer nuclear layer cysts (p=0.009). …”

Untargeted <i>In Vitro</i> Metabolomics data from <i>Burkholderia cenocepacia </i>J2315, H111 and <i>Staphylococcus aureus </i>NRS77 Biofilm Supernatant by Hayden Skaggs (20833868)

“…The solvent gradient was set as 0-6 min 0% B, 6-14 min increased from 0% to 28% B, 14-16 min increased from 28% to 50% B, 16-20 min increased from 50% to 100% B, 21-33 min back to 0% B. …”

DataSheet_1_Large-scale genome-wide association study to identify causal relationships and potential mediators between education and autoimmune diseases.docx by Yingjie Li (2106778)

“…Higher levels of educational attainment decreased risks of psoriasis (OR = 0.61, 95% CI = 0.52-0.72, p = 1.12×10^-9), RA (OR = 0.68, 95% CI = 0.59-0.79, p = 1.56×10^-7), and hypothyroidism (OR = 0.80, 95% CI = 0.72-0.88, p = 5.00×10^-6). …”

DataSheet_2_Large-scale genome-wide association study to identify causal relationships and potential mediators between education and autoimmune diseases.xlsx by Yingjie Li (2106778)

“…Higher levels of educational attainment decreased risks of psoriasis (OR = 0.61, 95% CI = 0.52-0.72, p = 1.12×10^-9), RA (OR = 0.68, 95% CI = 0.59-0.79, p = 1.56×10^-7), and hypothyroidism (OR = 0.80, 95% CI = 0.72-0.88, p = 5.00×10^-6). …”

Dupilumab improves sense of smell and clinical outcomes in patients with severe chronic rhinosinusitis with nasal polyps with anosmia by Andrew P. Lane (20367704)

“…</p> <p>Of 724 patients, 665 (91.9%) had smell impairment at baseline; most had anosmia (UPSIT 0–18) (dupilumab/placebo: 80.9%/79.8%). At week 24, the proportion of dupilumab-treated patients with anosmia decreased to 28.5%, while 14.9% achieved normosmia; most placebo-group patients (79.2%) remained anosmic and only 1.2% achieved normosmia (odds ratio = 17.3; 95% confidence interval = 5.1–59.0; <i>p</i> <.0001); results were similar at week 52. …”

Table_1_Silicon enhances plant resistance to Fusarium wilt by promoting antioxidant potential and photosynthetic capacity in cucumber (Cucumis sativus L.).docx by Shuangsheng Sun (13952469)

“…Compared with Fo, the activities of peroxidase (POD), catalase (CAT), and ascorbate peroxidase (APX) significantly increased by 148.92%, 26.47%, and 58.54%, while the contents of H₂O₂, O2·−, and malondialdehyde (MDA) notably decreased by 21.67%, 59.67%, and 38.701%, respectively, in roots of cucumber plants treated with Si + Fo. …”

Changes in soil microbial communities after 10 years of winter wheat cultivation versus fallow in an organic-poor soil in the Loess Plateau of China by Hui Tian (322212)

“…In this study, we examined three existing soil management regimes as part of a 10-year field experiment and evaluated their effects on fungal and bacterial community structures by performing high-throughput 454 pyrosequencing. …”

Image_1_Global, regional, and national burden of age-related macular degeneration, 1990–2019: an age-period-cohort analysis based on the Global Burden of Disease 2019 Study.PDF by Yufan Huang (7034540)

“…</p>Results<p>Globally, the number of DALYs increased from 296771.9321 (95% uncertainty interval [UI], 205462.8041–418699.8184) in 1990 to 564055.0967 (95% UI, 392930.6967–789194.6407) in 2019 (59.7% were female), while the age-standardized DALYs rates decreased from 8.29 per 100,000 (95% UI, 5.8–11.58/100,000) to 7.05 per 100,000 (95% UI, 4.92–9.84/100,000). …”

Table_1_Global, regional, and national burden of age-related macular degeneration, 1990–2019: an age-period-cohort analysis based on the Global Burden of Disease 2019 Study.xlsx by Yufan Huang (7034540)

“…</p>Results<p>Globally, the number of DALYs increased from 296771.9321 (95% uncertainty interval [UI], 205462.8041–418699.8184) in 1990 to 564055.0967 (95% UI, 392930.6967–789194.6407) in 2019 (59.7% were female), while the age-standardized DALYs rates decreased from 8.29 per 100,000 (95% UI, 5.8–11.58/100,000) to 7.05 per 100,000 (95% UI, 4.92–9.84/100,000). …”

Trends in types of protein in US adolescents and children: Results from the National Health and Nutrition Examination Survey 1999-2010 by Hyunju Kim (124616)

“…Among adolescents, beef intake decreased (0.92 to 0.67 g/kg) whereas chicken (0.59 to 0.74 g/kg) and all poultry (0.72 to 0.86 g/kg) intake increased from 1999 to 2010 (all <i>P</i><0.01). …”

Table1_Trp-574-Leu and the novel Pro-197-His/Leu mutations contribute to penoxsulam resistance in Echinochloa crus-galli (L.) P. Beauv..docx by Penglei Sun (18343673)

“…The whole-plant dose–response testing of E. crus-galli to penoxsulam confirmed the evolution of moderate-level resistance in two populations, JL-R (9.88-fold) and HLJ-R (8.66-fold), and a high-level resistance in AH-R (59.71-fold) population. …”

Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE^-/- mice by Julian Jehle (586001)

“…This was accompanied by a significant increase in infiltrating macrophages within the atherosclerotic vessel wall (0.33 ± 0.02 vs. 0.27 ± 0.01; n = 13–14; p = 0.0076). …”

Data_Sheet_1_Evaluating the effect of the plan of national syphilis control in controlling the syphilis epidemic in Jiangsu, China 2010–2020.docx by Lingen Shi (11246098)

“…Background<p>Starting in 2010, the Chinese government initiated a 10-year syphilis control plan, called the national syphilis control plan (NSCP), to address the emerging threat of syphilis. We aimed to evaluate the effect of the NSCP plan on syphilis control in Jiangsu, China.…”

HSP-4/BiP is required for the normal structure and barrier function of the cuticle in adults and alae formation in dauers. by Ji Zha (3386177)

“…Staining was performed as previously described [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000196#pbio.3000196.ref059" target="_blank">59</a>]. …”

The Homeobox Gene <i>MEIS1</i> Is Methylated in <i>BRAF</i>^p.V600E Mutated Colon Tumors by Ashwin A. Dihal (481201)

“…<i>MEIS1</i> methylation was associated with decreased <i>MEIS1</i> gene expression in both patient samples and CRC cell lines. …”

Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease by Chelsea Caspell-Garcia (4030664)

“…<div><p>Objectives</p><p>To assess the neurobiological substrate of initial cognitive decline in Parkinson’s disease (PD) to inform patient management, clinical trial design, and development of treatments.</p><p>Methods</p><p>We longitudinally assessed, up to 3 years, 423 newly diagnosed patients with idiopathic PD, untreated at baseline, from 33 international movement disorder centers. …”

Table_1_Trends and disparities in disease burden of age-related macular degeneration from 1990 to 2019: Results from the global burden of disease study 2019.doc by Bo Jiang (76119)

“…The ASPR of AMD had a decreased trend with an EAPC of −0.15 (95% confidence interval [CI], −0.2 to −0.11) from 1990 to 2019, and the ASYR of AMD showed a decreased trend with an EAPC of −0.71 (95% confidence interval [CI], −0.78 to −0.65) during this period. …”

Effect of Integrated Capacity-Building Interventions on Malaria Case Management by Health Professionals in Uganda: A Mixed Design Study with Pre/Post and Cluster Randomized Trial C... by Martin Kayitale Mbonye (507318)

“…<div><p>Background</p><p>The Integrated Infectious Diseases Capacity Building Evaluation (IDCAP) designed two interventions: Integrated Management of Infectious Disease (IMID) training program and On-Site Support (OSS). We evaluated their effects on 23 facility performance indicators, including malaria case management.…”