Maternal β-catenin activity is hyperactivated in <i>nanog</i> mutant. by Mudan He (7017239)

“…(I) TOPflash assay showing β-catenin transcriptional activity was significantly up-regulated in the embryos of MZ<i>nanog</i> compared with WT, and co-injection of <i>ctnnb2</i> MO (+ <i>β2</i> MO) but not <i>ctnnb1</i> MO (+ <i>β1</i> MO) into MZ<i>nanog</i> embryos significantly decreased the transcriptional activity. Error bars, mean ± SD, **<i>P</i> < 0.01, ***<i>P</i> < 0.001. …”

Tuning of Msn2 expression in rapidly growing cells. by Michal Chapal (7961111)

“…(F–G) Noisy Msn2 expression decreases stress protection and growth rate: we generated six strains with Msn2-YFP expressed under different promoters, which control genes with noisier expression than Msn2 but have a similar mean abundance (mean abundance in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3000289#pbio.3000289.s005" target="_blank">S5 Fig</a>), and deletion of <i>MSN4</i>. …”

Proxy-based paleoclimate series for the last 5000 years. by David Kaniewski (218243)

“…A lower ratio indicates an increase in humidity; (<b>i</b>) Estimated rainfall regimes at Tell Breda, Syria, obtained by correcting mean annual precipitation at Qameshli <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071004#pone.0071004-Fiorentino1" target="_blank">[71]</a>; (<b>j</b>) Estimated rainfall regimes at Ras El-Ain, Syria, obtained by correcting mean annual precipitation at Qameshli <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071004#pone.0071004-Fiorentino1" target="_blank">[71]</a>.…”

Hypothetical Scheme. by Bhanu Priya Ganesh (456697)

“…Increased gene expression of IFN-γ and IP-10 indicate an increased NK-cell recruitment. mLN - mesenteric lymph nodes, NK- Natural killer cells. (↑ increased; ↓ decreased; grey dotted line: assumed processes including lectin-sialic acid binding <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074963#pone.0074963-Giannasca1" target="_blank">[56]</a>, M-cells for pathogen transit <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074963#pone.0074963-McGuckin1" target="_blank">[43]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074963#pone.0074963-Clark1" target="_blank">[58]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074963#pone.0074963-Foster1" target="_blank">[59]</a>; black line: supported by data of the present study).…”

Table_1_Racial and regional disparities of triple negative breast cancer incidence rates in the United States: An analysis of 2011–2019 NPCR and SEER incidence data.docx by Wei Zhang (405)

“…TNBC occurred disproportionally higher in women of Non-Hispanic Black, younger ages, with cancer at a distant stage or poorly/undifferentiated. The age adjusted incidence rate (AAIR) for TNBC in all races decreased from 14.8 per 100,000 in 2011 to 14.0 in 2019 (annual percentage change (APC) = −0.6, P = 0.024). …”

Effect of TCERG1 knockdown on Fas-mediated apoptosis. by Marta Montes (812749)

“…Control and TCERG1 knockdown (KD) Jurkat cells were incubated with annexin-V and analyzed by flow cytometry in the absence (-) or presence (+) of 50 ng/ml of anti-Fas/CD95 for 6 h. The bar graph shows the percentage of annexin-V positive cells from three independent experiments (means ± SEM). *, <i>p</i> < 0.05. …”

Data_Sheet_1_State-Independent and -Dependent Structural Connectivity Alterations in Depression.PDF by Yiming Fan (2622457)

“…After 6-month antidepressant treatment, 68 patients received a second scan, among which 59 patients achieved full clinical remission. …”

Hypoglycemic effect of okra aqueous extract on streptozotocin-induced diabetic rats by Li WU (8141625)

“…Comparing with streptozotocin-induced diabetic rats group, the aqueous extract of okra treatment group exhibited decreasing blood glucose level (10.11%), glucose tolerance (12.00%), total triglyceride (41.59%), atherosclerosis index (49.20%), urine sugar (91.91%) and increasing insulin secretion (17.44%) and pyruvate kinase activity (57.41%). …”

Data_Sheet_1_Ecological Insights Into Community Interactions, Assembly Processes and Function in the Denitrifying Phosphorus Removal Activated Sludge Driven by Phosphorus Sources.d... by Lei Zheng (106363)

“…In this study, 59 denitrifying phosphorus removal (DPR) activated sludge samples were cultivated with phosphorus sources. …”

Table_1_Circulating microRNA-125b Levels Are Associated With the Risk of Vascular Calcification in Healthy Community-Dwelling Older Adults.doc by Chia-Ter Chao (111849)

“…Those with more severe AAC had progressively decreasing miR-125b levels (p<0.001). Multiple regression analyses showed that having higher miR-125b levels based on the median value were associated with a substantially lower risk of AAC [odds ratio (OR) 0.022, 95% confidence interval (CI) 0.011–0.044] compared to those having lower ones. …”

Image 6_Burden of pulmonary arterial hypertension in children globally, regionally, and nationally (1990–2021): results from the global burden of disease study.tif by Lili Deng (152262)

“…Significantly, reductions were observed in both mortality and disability-adjusted life years (DALYs) associated with pediatric PAH, with mortality decreasing by 57.66% and DALYs by 63.59% over the study period, indicating progress in mitigating the disease burden. …”

Image 3_Burden of pulmonary arterial hypertension in children globally, regionally, and nationally (1990–2021): results from the global burden of disease study.tif by Lili Deng (152262)

“…Significantly, reductions were observed in both mortality and disability-adjusted life years (DALYs) associated with pediatric PAH, with mortality decreasing by 57.66% and DALYs by 63.59% over the study period, indicating progress in mitigating the disease burden. …”

Cotransfected human chondrocytes: over-expression of IGF-I and SOX9 enhances the synthesis of cartilage matrix components collagen-II and glycosaminoglycans by M. Simental-Mendía (6511595)

“…At day 9 post-transfection, the chondrocytes that were over-expressing IGF-I/SOX9 showed 2-fold increased mRNA expression of the Col-II gene, as well as a 57% increase in Col-II protein, whereas type I collagen expression (Col-I) was decreased by 59.3% compared with controls. …”

ORN first-spike latency for single odorants and mixtures. by Ho Ka Chan (6065453)

“…<p>(<b>a</b>) The average first-spike latency predicted by our model ORNs decreases with the number of components in the odor stimulus. …”

Data_Sheet_1_Screening of Key Drought Tolerance Indices for Cotton at the Flowering and Boll Setting Stage Using the Dimension Reduction Method.xlsx by FengLei Sun (11102019)

“…Therefore, the indicator dimension decreased from 19 to 5. A comparison of the 19 indicators with the 5 identified indicators through PCA and a combined regression analysis found that the results of the final cluster of drought tolerance on 104 cotton varieties were basically consistent. …”

Image 1_Burden of pulmonary arterial hypertension in children globally, regionally, and nationally (1990–2021): results from the global burden of disease study.tif by Lili Deng (152262)

“…Significantly, reductions were observed in both mortality and disability-adjusted life years (DALYs) associated with pediatric PAH, with mortality decreasing by 57.66% and DALYs by 63.59% over the study period, indicating progress in mitigating the disease burden. …”

DataSheet_1_The effect of exopolysaccharides from EMS-induced Porphyridium cruentum mutant on human epidermal and dermal layers.docx by Sang-Il Han (11549857)

“…Despite maintaining the total pigment content, specific components changed significantly: chlorophyll content decreased 2.20- and 3.61-fold under white and blue light respectively, while phycobiliproteins increased 1.59- and 1.23-fold under the same conditions. …”

Effects of Management on Lichen Species Richness, Ecological Traits and Community Structure in the Rodnei Mountains National Park (Romania) by Ioana Violeta Ardelean (840969)

“…It reduced the mean level of threatened species richness by 59%, when all lichen species were considered, and by 81%, when only epiphytic lichens were considered. …”

Table 2_Burden of pulmonary arterial hypertension in children globally, regionally, and nationally (1990–2021): results from the global burden of disease study.docx by Lili Deng (152262)

“…Significantly, reductions were observed in both mortality and disability-adjusted life years (DALYs) associated with pediatric PAH, with mortality decreasing by 57.66% and DALYs by 63.59% over the study period, indicating progress in mitigating the disease burden. …”

Supplementary Material for: Sex-Specific Associations of Androgen Receptor CAG Trinucleotide Repeat Length and of Raloxifene Treatment with Testosterone Levels and Perceived Stress... by Owens S.J. (5991524)

“…Patients with schizophrenia (59 males and 38 females) participated in a randomized, double-blind, placebo-controlled, crossover trial of adjunctive raloxifene (120 mg/day). …”