The DEDI-domain of caspase 8 is critical for its interaction with Bcl2. by Mahbuba Rahman (198499)

“…Over-expression of wild-type caspase 8 in resistant cells further decreased cell viability following exposure to rSPARC and 5-FU, in comparison to EV-controls: MIP/5FU: 69.89±4.64 (SPARC + 5-FU) vs. 59.21±3.66% (SPARC + 5-FU + caspase 8) (p = 0.03); MiaPaca/CPT: 73.98±4.46 (SPARC + 5-FU) vs. 46.78±2.01% (SPARC + 5-FU + caspase 8) (p<0.005). …”

Data_Sheet_1_Northern Benguela Merluccius paradoxus Annual Growth From Otolith Chronologies Used for Age Verification and as Indicators of Fisheries-Induced and Environmental Chang... by Margit R. Wilhelm (8815913)

“…We also determined that mean length-at-age 3 calculated from ALKs (current and literature) significantly increased from 1977 through 2016 at 0.075 cm.year^–1 (t = 3.04, df = 41, p = 0.004), while length-at-age 8 significantly decreased at 0.25 cm.year^–1 (t = −3.59, df = 30, p = 0.001). …”

Simultaneous idiopathic bilateral sudden hearing loss - characteristics and response to treatment by Ferit Akil (4893706)

“…Results The mean ages of patients with unilateral and bilateral sudden hearing loss were 42.0 years and 24.5 years respectively with a statistically significant difference (p < 0.001). …”

Table1_Anemia Increases Oxygen Extraction Fraction in Deep Brain Structures but Not in the Cerebral Cortex.DOCX by Jian Shen (124641)

“…However, an opposite relationship was observed for OEF measurements in sagittal sinus (SS) with the widely used T₂-based oximetry, T₂-Relaxation-Under-Spin-Tagging (TRUST), in the same cohorts (31.2% ± 6.6% in SCD, 33.3% ± 5.9% in ACTL and 36.8% ± 5.6% in CTL). Importantly, we demonstrated that hemoglobin F and other fast moving hemoglobins decreased OEF by TRUST and explained group differences in sagittal sinus OEF between anemic and control subjects. …”

Increased aggregation propensity enhances Pept-in antimicrobial potency by promoting Pept-in accumulation and IB formation. by Guiqin Wu (760045)

“…<b>C:</b> Time dependence of pFTAA (0.5 μM) fluorescence intensity of P2 derivatives (50 μM) in the presence of polyP (0.5 mM) (n = at least 6). …”

Image_1_Increased Sestrin3 Contributes to Post-ischemic Seizures in the Diabetic Condition.JPEG by Zhongshan Shi (9989771)

“…Electrophysiological recording showed an increased excitatory synaptic transmission and intrinsic membrane excitability in dentate granule cells of the rat hippocampus, together with decreased I_A currents and Kv4.2 expression levels. …”

Video_1_Increased Sestrin3 Contributes to Post-ischemic Seizures in the Diabetic Condition.MP4 by Zhongshan Shi (9989771)

“…Electrophysiological recording showed an increased excitatory synaptic transmission and intrinsic membrane excitability in dentate granule cells of the rat hippocampus, together with decreased I_A currents and Kv4.2 expression levels. …”

Video_2_Increased Sestrin3 Contributes to Post-ischemic Seizures in the Diabetic Condition.MP4 by Zhongshan Shi (9989771)

“…Electrophysiological recording showed an increased excitatory synaptic transmission and intrinsic membrane excitability in dentate granule cells of the rat hippocampus, together with decreased I_A currents and Kv4.2 expression levels. …”

Organic material combined with beneficial bacteria improves soil fertility and corn seedling growth in coastal saline soils by Naidan Zhang (10378379)

“…Compared with all other FB treatments, soil total nitrogen, available phosphorus, and available potassium were increased by 4.78~18.04 %, 8.99~25.59 %, and 0.96~36.25 %, respectively, in F6B3. This treatment decreased soil total salt content by 0.79~12.72 %, compared with the other FB treatments. …”

Dfos increases Rho1-GTP, the formin Diaphanous and actin at the cortex through Cher and TM4SF. by Vera Belyaeva (11914218)

“…Line length approximately 8 μm. Blue lines indicate mean GFP intensity on the membrane and in cytoplasm. …”

Table_1_Effect and Safety of Adding Metformin to Insulin Therapy in Treating Adolescents With Type 1 Diabetes Mellitus: An Updated Meta-Analysis of 10 Randomized Controlled Trials.... by Ying Liu (18461)

“…Results suggested that metformin significantly decreased the HbA1c level at 12 months (mean difference [MD])=-0.50, 95% confidence interval [CI]=-0.61 to -0.39, P < 0.01); BMI (kg/m²) at 3 months (MD=-1.05, 95%CI=-2.05 to -0.05, P=0.04); BMI z-score at 6 months (MD=-0.10, 95%CI=-0.14 to -0.06, P<0.01); and TIDD at 3 (MD=-0.13, 95%CI=-0.20 to -0.06, P<0.01), 6 (MD=-0.18, 95%CI=-0.25 to -0.11, P<0.01), and 12 (MD=-0.42, 95%CI=-0.49 to -0.35, P<0.01) months but significantly increased the risk of hypoglycemia events (risk ratio [RR]=3.13, 95%CI=1.05 to 9.32, P=0.04) and GIAEs (RR=1.64, 95%CI=1.28 to 2.10, P<0.01). …”

Data Sheet 1_Effect of high intakes of protein-only and carbohydrate-only on plasma metabolites and hormones, in addition to nitrogen excretion.xlsx by Matthieu Clauss (9769343)

“…</p>Methods<p>Fourteen young, healthy, moderate-to-well-trained participants (VO_2max 50.6 ± 2.9 mL·kg^-1·min^-1; mean ± SEM) reported in the morning after an overnight fast. …”

Table1_Longitudinal Trend of Plasma Concentrations of Extracellular Vesicles in Patients Hospitalized for COVID-19.DOCX by Elena Campello (11953730)

“…The following EVs were measured: endothelium-, platelet-, leukocyte-derived, bearing tissue factor (TF)+, angiotensin-converting enzyme (ACE2)+, platelet-derived growth factor receptor-β (PDGF-β)+ and SARS-CoV-2-nucleoprotein (NP)+. 91 patients were recruited for baseline EV analysis (mean age 67 ± 14 years, 50.5% male) and 48 underwent the longitudinal evaluation. …”

VER-155008 caused a significant reduction in viral transcripts in HEK-293T rKSHV.219 cells. by Belinda Baquero-Pérez (706834)

“…All samples were normalised to <i>GAPDH</i>. Results show the mean of three biological replicates with error bar as standard deviation. …”

Table_2_Effect and Safety of Adding Metformin to Insulin Therapy in Treating Adolescents With Type 1 Diabetes Mellitus: An Updated Meta-Analysis of 10 Randomized Controlled Trials.... by Ying Liu (18461)

“…Results suggested that metformin significantly decreased the HbA1c level at 12 months (mean difference [MD])=-0.50, 95% confidence interval [CI]=-0.61 to -0.39, P < 0.01); BMI (kg/m²) at 3 months (MD=-1.05, 95%CI=-2.05 to -0.05, P=0.04); BMI z-score at 6 months (MD=-0.10, 95%CI=-0.14 to -0.06, P<0.01); and TIDD at 3 (MD=-0.13, 95%CI=-0.20 to -0.06, P<0.01), 6 (MD=-0.18, 95%CI=-0.25 to -0.11, P<0.01), and 12 (MD=-0.42, 95%CI=-0.49 to -0.35, P<0.01) months but significantly increased the risk of hypoglycemia events (risk ratio [RR]=3.13, 95%CI=1.05 to 9.32, P=0.04) and GIAEs (RR=1.64, 95%CI=1.28 to 2.10, P<0.01). …”

Phase 2b study of evocalcet (KHK7580), a novel calcimimetic, in Japanese patients with secondary hyperparathyroidism undergoing hemodialysis: A randomized, double-blind, placebo-co... by Tadao Akizawa (316095)

“…Adverse events were observed in 30%–50% of patients (all groups). Incidence of adverse events was similar among all groups except for decreased calcium, which occurred more frequently in the evocalcet 2 mg and cinacalcet groups.…”

Supplementary Material for: Magnetic Resonance Spectroscopy following Mild Traumatic Brain Injury: A Systematic Review and Meta-Analysis on the Potential to Detect Posttraumatic Ne... by Eisele A. (9071537)

“…For the meta-analysis, 50 mTBI patients and 51 HC with a mean age of 31 and 30 years, respectively, were scanned using <i>N</i>-acetyl-aspartate (NAA), a marker for neuronal integrity. …”

Impact of Vitamin D Supplementation on Arterial Vasomotion, Stiffness and Endothelial Biomarkers in Chronic Kidney Disease Patients by Nihil Chitalia (539263)

“…</p><p>Results</p><p>Clinical characteristics of 26 patients were: age 50±14 (mean±1SD) years, eGFR 41±11 ml/min/1.73 m², males 73%, dyslipidaemia 36%, smokers 23% and hypertensives 87%.…”

<i>Igf-1r</i> hemizygosity has minimal effect on the levels of mutant huntingtin protein. by Silvia Corrochano (618848)

“…Scale bar represents 50 µm. <b>E</b>. Automated quantification of images from D according to aggregate size reveal an increase in the percentage of small-size aggregates (0–0.3 µm²) coupled with a decreased in the percentage of medium-sized aggregates (0.3–0.9 µm²) in HD; <i>Igf-1r^+/−</i> cerebellum compared to controls (p<0.001). …”

Symbiotic drink based on Brazil nuts (Bertholletia excelsa H.B.K): production, characterization, probiotic viability and sensory acceptance by Paulo Cezar da Cunha Júnior (10441931)

“…<div><p>ABSTRACT: Brazil nut is a typical oilseed from the Amazon region, of great economic and cultural importance. …”