Data_Sheet_1_Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos.PDF by Auke B. C. Otten (8965244)

“…Morphant embryos displayed abnormal development of the eye, brain, heart, and muscle, as well as a 50 ± 22% decrease in ATP production. Transcriptome analysis revealed a decrease in protein-encoding transcripts from the heavy strand of the mtDNA, and down-regulation of genes involved in haem production and the metabolism of metabolites, which appear to trigger increased rRNA and tRNA synthesis in the nucleoli. …”

Data_Sheet_3_Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos.PDF by Auke B. C. Otten (8965244)

“…Morphant embryos displayed abnormal development of the eye, brain, heart, and muscle, as well as a 50 ± 22% decrease in ATP production. Transcriptome analysis revealed a decrease in protein-encoding transcripts from the heavy strand of the mtDNA, and down-regulation of genes involved in haem production and the metabolism of metabolites, which appear to trigger increased rRNA and tRNA synthesis in the nucleoli. …”

Supplementary Material for: Selective Serotonin Reuptake Inhibitors and Serotonin Noradrenaline Reuptake Inhibitors withdrawal changes DSM presentation of mental disorders: Results... by Cosci F. (4134769)

“…Using a new nosographic classification of withdrawal syndromes due to SSRI/SNRI decrease or discontinuation (by Chouinard and colleagues), we explored whether DSM is adequate to identify DSM disorders when withdrawal occurs. …”

Data_Sheet_2_Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos.pdf by Auke B. C. Otten (8965244)

“…Morphant embryos displayed abnormal development of the eye, brain, heart, and muscle, as well as a 50 ± 22% decrease in ATP production. Transcriptome analysis revealed a decrease in protein-encoding transcripts from the heavy strand of the mtDNA, and down-regulation of genes involved in haem production and the metabolism of metabolites, which appear to trigger increased rRNA and tRNA synthesis in the nucleoli. …”

Data_Sheet_4_Tfam Knockdown Results in Reduction of mtDNA Copy Number, OXPHOS Deficiency and Abnormalities in Zebrafish Embryos.PDF by Auke B. C. Otten (8965244)

“…Morphant embryos displayed abnormal development of the eye, brain, heart, and muscle, as well as a 50 ± 22% decrease in ATP production. Transcriptome analysis revealed a decrease in protein-encoding transcripts from the heavy strand of the mtDNA, and down-regulation of genes involved in haem production and the metabolism of metabolites, which appear to trigger increased rRNA and tRNA synthesis in the nucleoli. …”

Dataset for: Vascular narrowing in pulmonary arterial hypertension is heterogeneous: rethinking resistance by Nina Rol (3929081)

“…Within each order the decrease in diameter of affected vessels is variable with an averaged diameter fraction of 50-70%. …”

Trilemma of life cycle carbon, employment, and costs of trucking industry's shift toward automation and electrification by Mandouri, Jafar

“…Autonomy and electrification combined could lead to a 50% decrease in emissions and 46% savings in life cycle costs. …”
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Probing Field Cancerization in the Gastrointestinal Tract Using a Hybrid Raman and Partial Wave Spectroscopy Microscope by Elena Kriukova (21524544)

Experimental Evidence for the Effect of Small Wind Turbine Proximity and Operation on Bird and Bat Activity by Jeroen Minderman (146256)

“…At shorter distances from operating turbines (0–5 m), bat activity (measured as the probability of a bat “pass” per hour) decreases from 84% (71–91%) to 28% (11–54%) as wind speed increases from 0 to 14 m/s. …”

Average changes in parameter trajectories. by Philippa J. Karoly (761618)

NMDA does not alter PPR but does potentiate postsynaptic responses to glycine. by Michelle L. Kloc (7359230)

“…Paired pulse ratio does not decrease after NMDA-induced potentiation. Top, average of 5 IPSCs from a single experiment before (black) and 5 min after NMDA (blue). …”

Evolution of mutation rates on simple fitness landscapes with different ruggedness. by Jeff Clune (53764)

“…The two colored points represent the mean fitness and mutation rate, both averaged over 50 runs where the mutation rate freely evolved, with initial rates of <i>U</i> = 1 (red) or 10⁻⁵ (blue). …”

Table_1_Understanding Thermostability Factors of Barley Limit Dextrinase by Molecular Dynamics Simulations.DOCX by Juan Du (118107)

Reversal of pathology in I2S knockout (mucopolysaccharidosis II) mice after three IT-lumbar injections of I2S. by Pericles Calias (334957)

Image_2_Understanding Thermostability Factors of Barley Limit Dextrinase by Molecular Dynamics Simulations.tif by Juan Du (118107)

Combined M002 and irradiation to neuroblastoma xenografts. by Lauren A. Gillory (469462)

“…Once tumors reached 300 mm³, animals received an intra-tumoral injection of vehicle [PBS + 10% glycerol, 50μL (n=10)] or M002 virus [1 × 10⁴ PFU / 50μL (n=10)]. …”

Effect of Gli blockade on growth of human ovarian cancer cells <i>in vivo</i>. by Qi Chen (144168)

The effect of coding time window on metabolically efficient information transmission. by Tomas Barta (8067509)

MK-2206 induced cytotoxicity, inhibited proliferation and was able to overcome the protective effects of the tumor microenvironment. by Vijay Ramakrishnan (117159)

“…<p>When we cultured MM cell lines with indicated concentrations of MK-2206 for 48 hrs we observed dose dependent decrease in <b>A)</b> viability as observed by MTT assays and <b>B)</b> tritiated thymidine uptake indicative of inhibition of proliferation albeit with differences in the sensitivity of cell lines to MK-2206. …”

Macromolecular biosynthetic parameters and metabolic profile in different life stages of <i>Leishmania braziliensis</i>: Amastigotes as a functionally less active stage by Marlene Jara (774474)