Developmental Toxicity of Surface-Modified Gold Nanorods in the Zebrafish Model by Zakaria, Zain Z

“…Lethality and developmental endpoints such as hatching, tail flicking, and developmental delays were assessed until 96 h post-fertilization (hpf). Results: we found that AuNR treatment decreases the survival rate in embryos in a dose-dependent manner. …”
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DNA Methylation in the Human Cerebral Cortex Is Dynamically Regulated throughout the Life Span and Involves Differentiated Neurons by Kimberly D. Siegmund (193233)

“…<div><p>The role of DNA cytosine methylation, an epigenetic regulator of chromatin structure and function, during normal and pathological brain development and aging remains unclear. Here, we examined by MethyLight PCR the DNA methylation status at 50 loci, encompassing primarily 5′ CpG islands of genes related to CNS growth and development, in temporal neocortex of 125 subjects ranging in age from 17 weeks of gestation to 104 years old. …”

Scutellarin’s Cardiovascular Endothelium Protective Mechanism: Important Role of PKG-I<i>α</i> by Lin Li (28817)

“…The activation of PKG–1α was then studied using targeted proteomic analysis (MRM-MS) checking the phosphorylation state of the autophosphorylation domain (aa42-94). Significant decrease in phosphorylation of PKG-Iα at Ser50, Ser72, Ser89 was induced by HR injury while SCU treatment significantly increased the phosphorylation of PKG-Iα, not only at Ser50, Ser72 and Ser89, but also at Ser44 and Thr58 (two novel phosphorylation domains). …”

Diet-Induced Alterations in Total and Metabolically Active Microbes within the Rumen of Dairy Cows by Abderzak Lettat (401387)

“…Cows were fed a total mixed ration with the forage portion being either barley silage (0% CS), a 50∶50 mixture of barley silage and corn silage (50% CS), or corn silage (100% CS). …”

Data Sheet 1_Analysis of serum amino acids and tryptophan metabolites to predict hepatic encephalopathy in portal hypertension patients receiving a transjugular intrahepatic portal... by Li Bao (323211)

“…Screened by the specific screening criteria (VIP > 1.0; P < 0.05; FC > 1.5, or FC < 0.67) on MetaboAnalyst 5.0 on-line platform, tryptophan (TRP) were identified as the potential biomarker (50.31 μmol/L in non-HE group vs 100.21 μmol/L in HE group). …”

DataSheet1_Mildly Increased Renin Expression in the Absence of Kidney Injury in the Murine Transverse Aortic Constriction Model.pdf by Marian Wesseling (8807429)

“…<p>Cardiorenal syndrome type 2 is characterized by kidney failure as a consequence of heart failure that affects >50% of heart failure patients. Murine transverse aortic constriction (TAC) is a heart failure model, where pressure overload is induced on the heart without any systemic hypertension or its consequences. …”

Supplementary Materials - Antitumor activity of new chemical compounds in triple negative mammary adenocarcinoma models by Maria V Giolito (8499600)

“…According to the need for the development of new anticancer agents, we have synthetized novel bioactive compounds and aimed to determine their antitumor action. …”

Rho Kinase Enhances Contractions of Rat Mesenteric Collecting Lymphatics by Kristine H. Kurtz (548350)

“…<div><p>The mechanisms that control phasic and tonic contractions of lymphatic vessels are poorly understood. We hypothesized that rho kinase ROCK, previously shown to increase calcium (Ca²⁺) sensitivity in vascular smooth muscle, enhances lymphatic contractile activity in a similar fashion. …”

Analysis of tumour vasculature with the addition of more USMB groups. by Deepa Sharma (278210)

“…The vasculature becomes less evident in the treated groups, with decreasing numbers of stained blood vessels. Images were taken at a 20x objective lens, and the scale bar denotes ~50μm. …”

The effects of laser acupuncture on the modulation of cartilage extracellular matrix macromolecules in rats with adjuvant-induced arthritis - Fig 5 by Tien-Chien Pan (6475403)

“…A scale bar indicates 50 μm.</p>…”

Dose response analysis of active compounds identified in the primary HTS. by Kishore Polireddy (153876)

“…Results represent mean +/− SD with n = 3. (c and d) compounds identified in the primary HTS screen do not alter ABCB6 expression in the ABCB6 over-expressing cells. …”

Supplemental figure 2. Muscle and liver Western blot data by Moore (7500608)

“…His glucose deltaAUC_{0-120 min} response to the first OGTT was 2.1 times that of the mean of the other 5 dogs. Unlike any of the other V dogs, his glycemic response improved markedly in the final vs the first OGTT (44% decrease in glucose deltaAUC_{0-120 min}), and his insulin and C-peptide responses both declined between the first and final OGTTs.…”

Membrane potential measurements when SLO3 channel antagonists are present in capacitated wild-type and SLO3 mutant sperm; no significant changes in ion permeabilities are seen comp... by Julio C. Chávez (399841)

“…When SLO3 channels are blocked in wild-type sperm, with either Ba²⁺ (1 mM), or clofilium (50 µM), no hyperpolarization is noted during capacitation and membrane permeability values are similar to those of non-capacitated wild-type sperm. …”

The public health system and the place of autism by Vanini Mandaj (16029441)

“…Half the sample (50%) had weekly therapy and received homeopathic medication; 24 users (21.81%) were referred by speech-language-hearing therapists and 19 (17.27%), by the school they attended. …”

Gene expression profiling, for genes involved in regulating cell cycle, in A549, MCF-7 and HepG2 cells incubated with or without etoposide under normoxic or hypoxic conditions by Jean-Philippe Cosse (37121)

“…Each value is the average of three ratio values calculated from three independent experiments ± 1 S.D. Mean ratios indicate a fold-increase or decrease in gene expression. …”

Pharmacological suppression of local activity abolishes non-linear interactions. by Michael T. Lippert (410615)

“…<p>A: General decrease in average rectified current source density (AVREC) caused by muscimol application (100 ms post-stimulus window, mean of both unisensory stimuli, n = 5, <i>P</i><0.05, U test). …”

Knockdown of <i>Lmo4</i> in the BLC leads to enhanced freezing to the context and the cue. by Rajani Maiya (123315)

“…Data are represented as mean ± SEM. n = 10–12/group. C) Left panel: Representative image of viral infection is shown. …”

Instability of retroviral vectors with HIV-1-specific RT aptamers due to cryptic splice sites in the U6 promoter-6 by Stephen E Braun (84385)

“…The reduction in expression of the mutant U6 promoter was 0.50 ± 0.12 fold (mean ± standard deviation [SD]).…”

Ndk contributes to phagosome maturation arrest. by Jim Sun (367834)

“…Values in B and D are the mean ± SD of phagosome colocalization of with FITC-DXT in 50–80 cells from three independent experiments.…”

LM11A-31 prevents cholinergic dystrophic neurites in cortex of late-stage APP^L/S mice. by Danielle A. Simmons (621167)

“…<p>Representative photomicrographs show clusters of cholinergic dystrophic neurites in the cortex of APP^L/S (APP) Veh (<b><i>A</i></b>) and APP-31 (<b><i>B</i></b>) mice. Scale bar in B = 50 µm. Quantitative analysis showed that LM11A-31 did not significantly affect the total area (<b><i>C</i></b>) or number (<b><i>D</i></b>) of clusters but did decrease the size or mean area per cluster (<b><i>E</i></b>). …”