Table 1_Case Report: Generalized anxiety disorder and hypertension: a bidirectional loop unraveled by integrated management.docx by Junming Chen (3603422)

“…Multimodal management combining pharmacotherapy (escitalopram, tandospirone), transcranial magnetic stimulation (9 sessions), biofeedback (14 sessions), psychotherapy, and lifestyle interventions achieve: mean BP decreased significantly from 176/105 mmHg to 125/72 mmHg during hospitalization; significant anxiety reduction (HAMA = 3), mean BP stabilized at 131/77 mmHg with 50% reduction in antihypertensive dosages, normalization of elevated ACTH (99.9→normal pg/mL) and cortisol (18.7→normal μg/dL) and sustained improvement at 6-month follow-up.…”

Germline variants analysis of Chinese breast cancer patients reveals numerous alterations in homologous recombination genes by Zhaoyun Jiang (15317737)

“…<p>We aimed to identify the pathogenic variants of homologous recombination (HR) genes and analyze the correlation between the pathogenic variants and clinical characteristics in Chinese breast cancer patients.…”

<i>Oxtr</i> promoter methylation changes <i>in vivo</i>. by Shimrat Mamrut (283008)

“…These differences are found in CpG sites 3–7. <b>E</b>) The mean relative methylation level of the <i>Oxtr</i> promoter, averaged over CpG sites 3–7, is decreased in the uterus in early postpartum and returns to baseline 24 h later. …”

<i>Pf</i>PKA-mediated phosphorylation contributes to immature GIE stiffness. by Ghania Ramdani (676819)

“…Black star indicates the expected size for <i>Pf</i>PKA-R (50.8 kDa); Red star indicates <i>Pf</i>PKA-R with post-translational modifications. …”

Generation of post-mitotic neurons requires NRG1-II. by Tomomi Sato (301255)

“…<i>4neurog1</i>:<i>nRFP</i>) at 50 hpf. Scale bar, 10 μm. <b>C</b>. Quantification of <i>neurod</i>:EGFP intensity in the OT for the experiment shown in A (mean ± s.e.m.; **<i>P</i> < 0.01; n = 4 per group). …”

Complementary interactions of cysteine and Fe(II) with 6PG. by Gabriel Piedrafita (155328)

“…<b>(B)</b> Representative ¹H-NMR spectra of 6PG alone, cysteine alone, or the combination of both (20 mM of each analyte) in 50 mM phosphate pH 5/D₂O solutions, either in the absence or presence of 1 mM FeCl₂. …”

Effect of IL-17A, IL-17F or IL-22 on TER of cultured ARPE-19 monolayer. by Ying Chen (9697)

“…Incubation of ARPE-19 monolayers with 50 ng/ml IL-17A or IL-17F induced a gradual decrease of TER, and a significant effect occurred 5 days (p = 0.019, p = 0.045) after stimulation. …”

Heat knock-down time of <i>Bicyclus anynana</i> in relation to sex, larval and adult feeding treatment. by Klaus Fischer (82645)

“…AS: adult starvation, AC: adult control. Given are means +1 SE. Sample sizes range between 12 and 50 per group.…”

Table_1_Adding scent: exploring improvements in pan trapping to monitor pollinators.docx by Madison M. Dunlap (17178190)

“…Scented traps shared between 53.0% and 79.7% similarity in Hymenoptera assemblage and 59.5% and 72.2% similarity when using presence/absence data as compared with the control. …”

Assessment of SnO2 nanoparticles' impact on the growth of Picochlorum maculatum algae by Bounnit, Touria

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Effects of 40 mg·kg⁻¹ wogonin on COX-2 expression, MMP-9 and NF-κB activation. by Chien-Cheng Chen (207053)

“…Quantification analysis showed that wogonin treatment induced a significantly greater decrease in NF-κB binding activity, expressed in arbitrary densitometric units (ADU), than that induced by vehicle treatment, measured by EMSA.Values are reported as means ± SEM; *<i>P</i><0.05, **<i>P</i><0.01, ***<i>P</i><0.001 versus sham controls, and ^†<i>P</i><0.05, ^†††<i>P</i><0.001 for wogonin-treated versus vehicle-treated TBI mice (n = 7 mice/group).…”

Novel derivative of Paeonol, Paeononlsilatie sodium, alleviates behavioral damage and hippocampal dendritic injury in Alzheimer's disease concurrent with cofilin1/phosphorylated-co... by Fei Han (24308)

“…<p><b>Effects of Pa on the behavioral performances in the OFT (A-C), EPMT (D-F) and MWMT (G, H)</b> (n = 8–10). Pa treatment (50 mg/kg, i.p.) attenuated the <i>D</i>-gal and AlCl₃-induced decrease in the number of squares crossed (<b>A</b>), the number of clean movements (<b>B</b>), and the number of rears (<b>C</b>) in the OFT. …”

Single-cell analysis reveals non-linear relationship between H3K27me3 and BCL6. by Ofir Griess (14761465)

“…BCL6 overexpression results in an increase in H3K27me3 as well as additional marks of heterochromatin, and a decrease in histone acetylation levels. <b>H.</b> H3K27me3 mean levels in cells binned according to BCL6 levels. …”

Pathways identified by IPA connects Bacopa to memory, neuroprotection and AD. by How-Wing Leung (4385896)

“…Explanation of the numbered connections: (1) ATF4 and NRF2 functionally interact with each other [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref040" target="_blank">40</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref043" target="_blank">43</a>]. (2) ATF4 is implicated in memory [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref059" target="_blank">59</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref062" target="_blank">62</a>]. (3) NRF is implicated in memory [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref063" target="_blank">63</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref067" target="_blank">67</a>]. (4) Translation initiation factor eIF2-alpha stimulates translation of ATF4 [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref068" target="_blank">68</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref071" target="_blank">71</a>]. (5) eIF2-alpha is implicated in memory formation [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref072" target="_blank">72</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref073" target="_blank">73</a>]. (6) ATF4 has been implicated in Alzheimer’s disease (AD) [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref074" target="_blank">74</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref078" target="_blank">78</a>]. (7) NRF2 has also been linked to AD [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref063" target="_blank">63</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref065" target="_blank">65</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref067" target="_blank">67</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref079" target="_blank">79</a>]. (8) NRF2 plays a critical role in neuroprotection [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref080" target="_blank">80</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref083" target="_blank">83</a>]. (9) FOXO3 mediates oxidative stress-induced neuronal cell death [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref084" target="_blank">84</a>–<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0182984#pone.0182984.ref087" target="_blank">87</a>]. …”

HGF upregulates CXCR4 expression and membrane presentation in human breast cancer cells. by Songyin Huang (189521)

“…Time course of the relative extracted CXCR4 mRNA expression in MDA-MB-436 and MCF-7 cells following stimulation with 50 ng/ml HGF. Results are presented as the mean ± SD of three independent experiments. # P<0.01,* P<0.05 as compared to PBS. …”

DataSheet1_Effects of Population Age on the Annual Net Primary Productivity and Seed Yield of Artificial Grasslands on the Eastern Qinghai-Tibetan Plateau.docx by Cong Li (115171)

“…We found that both ANPP and seed yield decreased linearly over time following planting for all species. …”

Baseline Transmission (None) and Five Intervention Scenarios: Q, QI, QA, QIA, and QIAC by Joseph T Wu (31525)

“…For the results presented here, we assumed a compliance rate of 50% (see <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.0030361#st2" target="_blank">Methods</a>). …”

Bulk Nanobubbles Fabricated by Repeated Compression of Microbubbles by Juan Jin (603043)

“…The microscopic results showed that microbubbles about 10–50 μm formed first and then decreased to be nanoscale-sized. …”

Table_1_Examining the associations between mental health, life balance, work-method autonomy, and perceived boundary control among postdoctoral fellows.DOCX by Brian K. Lo (20449568)

“…Both work-method autonomy and perceived boundary control were positively associated with life balance [B = 0.40, 95% CI = [0.20–0.60]; B = 0.50, 95% CI = [0.32–0.67], respectively]. …”

Table_2_Examining the associations between mental health, life balance, work-method autonomy, and perceived boundary control among postdoctoral fellows.DOCX by Brian K. Lo (20449568)

“…Both work-method autonomy and perceived boundary control were positively associated with life balance [B = 0.40, 95% CI = [0.20–0.60]; B = 0.50, 95% CI = [0.32–0.67], respectively]. …”