Effects of siRNA on RET/PTC3 Junction Oncogene in Papillary Thyroid Carcinoma: From Molecular and Cellular Studies to Preclinical Investigations by Hafiz Muhammad Ali (554920)

“…Among four siRNAs and five concentrations tested against <i>RET/PTC3</i>, an efficient siRNA <i>RET/PTC3</i> and an appropriate dose (50 nM) were selected which showed significant inhibition (<i>p</i><0.001) of gene (RT-qPCR) and protein (Western blot) expressions. …”

Neutrophil extracellular traps contribute to the pathogenesis of leprosy type 2 reactions by Camila Oliveira da Silva (7365539)

“…<div><p>Up to 50% of patients with the multibacillary form of leprosy are expected to develop acute systemic inflammatory episodes known as type 2 reactions (T2R), thus aggravating their clinical status. …”

Image_2_Phenotyping and Quantitative Trait Locus Analysis for the Limited Transpiration Trait in an Upper-Mid South Soybean Recombinant Inbred Line Population (“Jackson” × “KS4895”... by Sayantan Sarkar (11975699)

“…The phenotyping results showed that 88% of slow, 50% of moderate, and 11% of high wilting genotypes expressed the TR_lim trait at 32°C and 43, 10, and 0% at 37°C, respectively. …”

Data_Sheet_1_Cardioprotecive Properties of Known Agents in Rat Ischemia-Reperfusion Model Under Clinically Relevant Conditions: Only the NAD Precursor Nicotinamide Riboside Reduces... by Yang Xiao (146335)

“…</p><p>Results: Pilot studies suggested potential cardioprotective effects for 50 mg/kg NR (p = 0.005) and 500 μg/kg melatonin (p = 0.12), but not for Empa or Fingo. …”

Table_1_Safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of WBP216, a novel IL-6 monoclonal antibody, in patients with rheumatoid arthritis: A phase Ia random... by Xiaomei Leng (614420)

“…Background<p>WBP216 is a novel human immunoglobulin G1 (IgG1) monoclonal antibody for interleukin (IL)-6. We aimed to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of a single ascending dose (SAD) of WBP216 in patients with rheumatoid arthritis (RA).…”

Image_1_Phenotyping and Quantitative Trait Locus Analysis for the Limited Transpiration Trait in an Upper-Mid South Soybean Recombinant Inbred Line Population (“Jackson” × “KS4895”... by Sayantan Sarkar (11975699)

“…The phenotyping results showed that 88% of slow, 50% of moderate, and 11% of high wilting genotypes expressed the TR_lim trait at 32°C and 43, 10, and 0% at 37°C, respectively. …”

DataSheet_5_T2DM may exert a protective effect against digestive system tumors in East Asian populations: a Mendelian randomization analysis.pdf by Ni An (511459)

“…</p>Results<p>T2DM is associated with a reduced risk of esophageal (OR: 0.77, 95% CI: 0.71 to 0.83, P< 0.001), gastric (OR: 0.87, 95% CI: 0.84 to 0.90, P< 0.001) and colorectal cancer (OR: 0.88, 95% CI: 0.85 to 0.91, P< 0.001) and hepatocellular carcinoma (OR: 0.92, 95% CI: 0.86 to 0.97, P = 0.005) and an increased risk of pancreatic cancer (OR: 1.92, 95% CI: 1.47 to 2.50, P< 0.001) in East Asian population. T2DM causes decreased fasting insulin levels (OR = 0.966, 95% CI: 0.95 to 0.98, P< 0.001) and increased glycated hemoglobin levels (OR=1.41, 95% CI: 1.39 to 1.44, P<0.001). …”

Data_Sheet_2_Phenotyping and Quantitative Trait Locus Analysis for the Limited Transpiration Trait in an Upper-Mid South Soybean Recombinant Inbred Line Population (“Jackson” × “KS... by Sayantan Sarkar (11975699)

“…The phenotyping results showed that 88% of slow, 50% of moderate, and 11% of high wilting genotypes expressed the TR_lim trait at 32°C and 43, 10, and 0% at 37°C, respectively. …”

Parallel fibers from areas outlined in (a) were analyzed in 250-μm-thick vibratome slices taken from HH35 cerebella after downregulation of AX-1 by RNAi at HH34 (a-c,f) by Thomas Baeriswyl (90047)

“…As an independent method for AX-1 perturbation, we used antibodies to block AX-1 function at the protein level. …”

Table_1_Compensatory brain activity pattern is not present in older adults during the n-back task performance—Findings based on EEG frequency analysis.DOC by Ludmiła Zając-Lamparska (8056364)

“…To strengthen the cognitive interpretation of compensatory brain activity in older adults, we searched for its indicators in brain activity measured by EEG.…”

Reliable and robust method for abdominal muscle mass quantification using CT/MRI: An explorative study in healthy subjects by Jisuk Park (7405823)

“…<div><p>Background</p><p>Quantification of abdominal muscle mass by cross-sectional imaging has been increasingly used to diagnose sarcopenia; however, the technical method for quantification has not been standardized yet. We aimed to determine an optimal method to measure the abdominal muscle area.…”

Image_2_T2DM may exert a protective effect against digestive system tumors in East Asian populations: a Mendelian randomization analysis.tiff by Ni An (511459)

“…</p>Results<p>T2DM is associated with a reduced risk of esophageal (OR: 0.77, 95% CI: 0.71 to 0.83, P< 0.001), gastric (OR: 0.87, 95% CI: 0.84 to 0.90, P< 0.001) and colorectal cancer (OR: 0.88, 95% CI: 0.85 to 0.91, P< 0.001) and hepatocellular carcinoma (OR: 0.92, 95% CI: 0.86 to 0.97, P = 0.005) and an increased risk of pancreatic cancer (OR: 1.92, 95% CI: 1.47 to 2.50, P< 0.001) in East Asian population. T2DM causes decreased fasting insulin levels (OR = 0.966, 95% CI: 0.95 to 0.98, P< 0.001) and increased glycated hemoglobin levels (OR=1.41, 95% CI: 1.39 to 1.44, P<0.001). …”

Data Sheet 1_Blue light modulates the interactive effects of far-red light and day–night temperature difference on the growth, morphology and physiology of arugula and lettuce.docx... by Awais Ali (8613051)

“…In contrast, blue light effectively suppresses stem elongation. We hypothesized that when stem elongation is suppressed by blue light, the combination of FR light and +DIF may enhance leaf expansion, instead of stem elongation, thereby enhancing photon capture and final biomass.…”

DataSheet_4_T2DM may exert a protective effect against digestive system tumors in East Asian populations: a Mendelian randomization analysis.pdf by Ni An (511459)

“…</p>Results<p>T2DM is associated with a reduced risk of esophageal (OR: 0.77, 95% CI: 0.71 to 0.83, P< 0.001), gastric (OR: 0.87, 95% CI: 0.84 to 0.90, P< 0.001) and colorectal cancer (OR: 0.88, 95% CI: 0.85 to 0.91, P< 0.001) and hepatocellular carcinoma (OR: 0.92, 95% CI: 0.86 to 0.97, P = 0.005) and an increased risk of pancreatic cancer (OR: 1.92, 95% CI: 1.47 to 2.50, P< 0.001) in East Asian population. T2DM causes decreased fasting insulin levels (OR = 0.966, 95% CI: 0.95 to 0.98, P< 0.001) and increased glycated hemoglobin levels (OR=1.41, 95% CI: 1.39 to 1.44, P<0.001). …”

DataSheet_3_T2DM may exert a protective effect against digestive system tumors in East Asian populations: a Mendelian randomization analysis.pdf by Ni An (511459)

“…</p>Results<p>T2DM is associated with a reduced risk of esophageal (OR: 0.77, 95% CI: 0.71 to 0.83, P< 0.001), gastric (OR: 0.87, 95% CI: 0.84 to 0.90, P< 0.001) and colorectal cancer (OR: 0.88, 95% CI: 0.85 to 0.91, P< 0.001) and hepatocellular carcinoma (OR: 0.92, 95% CI: 0.86 to 0.97, P = 0.005) and an increased risk of pancreatic cancer (OR: 1.92, 95% CI: 1.47 to 2.50, P< 0.001) in East Asian population. T2DM causes decreased fasting insulin levels (OR = 0.966, 95% CI: 0.95 to 0.98, P< 0.001) and increased glycated hemoglobin levels (OR=1.41, 95% CI: 1.39 to 1.44, P<0.001). …”

Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells by Damodara Reddy Vaddi (467087)

“…The changes in protein expression were associated with ~50% decrease in hERG potassium conductance. ER retention of hERG 125kDa form by CH was due to defective trafficking and was rescued by exposing cells to hypoxia at low temperatures or treatment with E-4031, a hERG channel blocker. …”

Highly Conductive and Mechanically Robust Cellulose Nanocomposite Hydrogels with Antifreezing and Antidehydration Performances for Flexible Humidity Sensors by Jie Yu (150626)

“…However, the conventional water-based conductive hydrogels tend to inevitably freeze at subzero temperature and suffer from continuous water evaporation under ambient conditions, leading to a decrease in their electrical conductivities and mechanical properties. …”

Image_2_Warming and CO2 Enhance Arctic Heterotrophic Microbial Activity.tif by Dolors Vaqué (683567)

“…Results showed that chlorophyll a concentration decreased at increasing temperatures, while BP significantly increased with pCO₂ at 6 and 10°C. …”

Image_4_T2DM may exert a protective effect against digestive system tumors in East Asian populations: a Mendelian randomization analysis.tif by Ni An (511459)

“…</p>Results<p>T2DM is associated with a reduced risk of esophageal (OR: 0.77, 95% CI: 0.71 to 0.83, P< 0.001), gastric (OR: 0.87, 95% CI: 0.84 to 0.90, P< 0.001) and colorectal cancer (OR: 0.88, 95% CI: 0.85 to 0.91, P< 0.001) and hepatocellular carcinoma (OR: 0.92, 95% CI: 0.86 to 0.97, P = 0.005) and an increased risk of pancreatic cancer (OR: 1.92, 95% CI: 1.47 to 2.50, P< 0.001) in East Asian population. T2DM causes decreased fasting insulin levels (OR = 0.966, 95% CI: 0.95 to 0.98, P< 0.001) and increased glycated hemoglobin levels (OR=1.41, 95% CI: 1.39 to 1.44, P<0.001). …”

Data_Sheet_1_Resting-state electroencephalogram in drug-free subjects with at-risk mental states who later developed psychosis: a low-resolution electromagnetic tomography analysis... by Yuko Higuchi (219691)

“…In this study, we measured the resting-state EEG power in ARMS, and investigated its features and the relationship between the power of the frequency bands and their diagnostic outcomes.…”