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18081
Visible-Light-Controlled Histone Deacetylase Inhibitors for Targeted Cancer Therapy
Published 2023“…Light-activatable drugs, whose activity can be precisely controlled with external light, could provide a more localized action of the drugs in the tumor, thus decreasing side effects and increasing efficacy. Herein, we introduce a series of photoswitchable azobenzene histone deacetylase inhibitors (HDACis) whose activity can be controlled by external visible light. …”
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18082
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18083
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18084
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18085
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18086
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18087
The effects of Mycobacterium tuberculosis on T cell responsiveness in granulomas
Published 2019“…At the cellular level, increased IFNγ concentrations are most sensitive to T cell levels between 30-40 days, while sensitivity of the binding threshold of MHCII peptide complexes that are required to activate T cells decreases in relation to T cell levels. Increased concentrations of Mtb antigens is most sensitive to granuloma size and infected macrophage, TNF-induced apoptosis rates from 25-50 days.…”
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18088
Vegetation changes in Jasper National Park assessed from resampling of ecological land classification plots established in the 1970s
Published 2025“…Within each plot, we determined the change in cover for each taxon. …”
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18089
Repair-Mediated Duplication by Capture of Proximal Chromosomal DNA Has Shaped Vertebrate Genome Evolution
Published 2009“…These events are thought to be a source of genomic instability and human diseases, but it is unclear whether they have contributed significantly to genome evolution. Here we developed an innovative computational pipeline that takes advantage of the repetitive structure of genomes to detect repair-mediated duplication events (RDs) that occurred in the germline and created insertions of at least 50 bp of genomic DNA. …”
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18090
Data_Sheet_1_The Paradoxical Leishmanicidal Effects of Superoxide Dismutase (SOD)-Mimetic Tempol in Leishmania braziliensis Infection in vitro.PDF
Published 2019“…Tempol surfaces as an interesting candidate for the chemotherapy of CL with an IC<sub>50</sub> of 0.66 ± 0.08 mM and selectivity index of 151. …”
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18091
Obesity is associated with increased basal and postprandial β-cell insulin secretion even in the absence of insulin resistance
Published 2020“…We tested the hypothesis that obesity, independent of insulin resistance, is associated with increased insulin secretion. …”
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18092
Self-Reducing Copper Precursor Inks and Photonic Additive Yield Conductive Patterns under Intense Pulsed Light
Published 2017“…Finally, we show that by adding as little as 0.5 wt % single-wall CNTs to the ink the absorptance was enhanced by about 50% and the threshold energy required to obtain a conductive pattern decreased by ∼25%. …”
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18093
Supplementary Material for: Polycystic Ovary Syndrome, Endometriosis and Venous Thromboembolism: A population-based study
Published 2025“…Results: We observed increasing trends, with a relative increase of 140% (from 0.27% to 0.65%) for PCOS, 16% (from 0.43% to 0.50%) for DVT, and 39% (from 0.23% to 0.32%) for PE, whereas we observed a decline by 34% for endometriosis (from 0.85% to 0.56%). …”
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18094
Depletion of HDAC6 Enhances Cisplatin-Induced DNA Damage and Apoptosis in Non-Small Cell Lung Cancer Cells
Published 2012“…Furthermore, we showed that HDAC6 protein levels were positively correlated with cisplatin IC<sub>50</sub> in 15 NSCLC cell lines. …”
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18095
Expression of Bcl-2, Bax, Survivin, ERK, cytochrome C, Caspase-3 and VEGF in 4T1 cells after 48 h treatment of fucoidan detected by Western blot.
Published 2013“…Fucoidan decreased VEGF expression in 4T1 cells. Lane 1: control cells; lanes 2–4: 4T1 cells treated with 50, 100 and 200 μg/ml fucoidan respectively. …”
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18096
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18097
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18098
Image1_Neuroprotective effects of total phenolics from Hemerocallis citrina Baroni leaves through the PI3K/AKT pathway.pdf
Published 2024“…PC12 cells were stimulated with 200 μmol/L Corticosterone (Cort) for 24 h, and then treated with 50, 100 and 200 μg/mL of HLTP for 24 h. The cell viability of damaged cells were significantly increased in a dose-dependent manner by 9.50%, 10.42% and 21.25%, respectively (P < 0.01). …”
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18099
Table1_Neuroprotective effects of total phenolics from Hemerocallis citrina Baroni leaves through the PI3K/AKT pathway.docx
Published 2024“…PC12 cells were stimulated with 200 μmol/L Corticosterone (Cort) for 24 h, and then treated with 50, 100 and 200 μg/mL of HLTP for 24 h. The cell viability of damaged cells were significantly increased in a dose-dependent manner by 9.50%, 10.42% and 21.25%, respectively (P < 0.01). …”
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18100
Table2_Neuroprotective effects of total phenolics from Hemerocallis citrina Baroni leaves through the PI3K/AKT pathway.docx
Published 2024“…PC12 cells were stimulated with 200 μmol/L Corticosterone (Cort) for 24 h, and then treated with 50, 100 and 200 μg/mL of HLTP for 24 h. The cell viability of damaged cells were significantly increased in a dose-dependent manner by 9.50%, 10.42% and 21.25%, respectively (P < 0.01). …”