Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Targeting P-glycoprotein (ABCB1 or P-gp) has been recognized as a promising strategy to overcome multidrug resistance. Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4‑<i>b</i>]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Assoc... by Mary A. Foutz (20361830)

“…Mitochondrial uncouplers such as BAM15 increase respiration and energy expenditure and have potential in treating a variety of metabolic diseases. In this study, we disclose the structure–activity relationship profile of 6-substituted [1,2,5]oxadiazolo[3,4-<i>b</i>]pyridin-7-ol derivatives of BAM15. …”

Data_Sheet_1_Marathon Running Increases Synthesis and Decreases Catabolism of Joint Cartilage Type II Collagen Accompanied by High-Energy Demands and an Inflamatory Reaction.PDF by José A. Hernández-Hermoso (11545663)

“…Mean sC2C levels (220.83 ± 39.50 ng/ml) decreased post-race (188.67 ± 38.52 ng/ml) (p = 0.002). …”

Biomechanical Energy Harvesters Based on Ionic Conductive Organohydrogels via the Hofmeister Effect and Electrostatic Interaction by Yinghong Wu (1462006)

“…Herein, we introduce the Hofmeister effect and electrostatic interaction to generate hydrogen and sodium bonds in the hydrogel. …”

Biomechanical Energy Harvesters Based on Ionic Conductive Organohydrogels via the Hofmeister Effect and Electrostatic Interaction by Yinghong Wu (1462006)

“…Herein, we introduce the Hofmeister effect and electrostatic interaction to generate hydrogen and sodium bonds in the hydrogel. …”

Biomechanical Energy Harvesters Based on Ionic Conductive Organohydrogels via the Hofmeister Effect and Electrostatic Interaction by Yinghong Wu (1462006)

“…Herein, we introduce the Hofmeister effect and electrostatic interaction to generate hydrogen and sodium bonds in the hydrogel. …”

Biomechanical Energy Harvesters Based on Ionic Conductive Organohydrogels via the Hofmeister Effect and Electrostatic Interaction by Yinghong Wu (1462006)

“…Herein, we introduce the Hofmeister effect and electrostatic interaction to generate hydrogen and sodium bonds in the hydrogel. …”

Number of primary school classes, 2013−2022. by Zhankun Han (20529082)

“…From 2013 to 2022, the number of elementary schools in rural areas was more than 50% of the total number of elementary schools. Rural elementary schools in China are scattered, the distribution rate of aesthetic education resources is low, and it is difficult to popularize high-quality aesthetic education resources. (2) The number of classes in China’s rural elementary schools decreased 30.28% from 1.139 million in 2013 to 788,000 in 2022. …”

Primary school enrollment 2013−2022. by Zhankun Han (20529082)

“…From 2013 to 2022, the number of elementary schools in rural areas was more than 50% of the total number of elementary schools. Rural elementary schools in China are scattered, the distribution rate of aesthetic education resources is low, and it is difficult to popularize high-quality aesthetic education resources. (2) The number of classes in China’s rural elementary schools decreased 30.28% from 1.139 million in 2013 to 788,000 in 2022. …”

Number of primary schools, 2013–2022. by Zhankun Han (20529082)

“…From 2013 to 2022, the number of elementary schools in rural areas was more than 50% of the total number of elementary schools. Rural elementary schools in China are scattered, the distribution rate of aesthetic education resources is low, and it is difficult to popularize high-quality aesthetic education resources. (2) The number of classes in China’s rural elementary schools decreased 30.28% from 1.139 million in 2013 to 788,000 in 2022. …”

S1 File - by Zhankun Han (20529082)

“…From 2013 to 2022, the number of elementary schools in rural areas was more than 50% of the total number of elementary schools. Rural elementary schools in China are scattered, the distribution rate of aesthetic education resources is low, and it is difficult to popularize high-quality aesthetic education resources. (2) The number of classes in China’s rural elementary schools decreased 30.28% from 1.139 million in 2013 to 788,000 in 2022. …”

Transcriptomic comparison between wild-type and ∆klf1 mutant cells in the VE or G0 phase. by Mizuki Shimanuki (475359)

Climate variable summary. by Dawn Robin Magness (6157265)

Image_1_Comparison Of The Gut Microbiota In Different Age Groups In China.tif by Hang Yan (2792143)

“…Our study divided the subjects (n=614) into two groups by using 50 years as the age cut-off point for the grouping. …”

Table_1_Comparison Of The Gut Microbiota In Different Age Groups In China.xlsx by Hang Yan (2792143)

“…Our study divided the subjects (n=614) into two groups by using 50 years as the age cut-off point for the grouping. …”

Correlation between Dengue-Specific Neutralizing Antibodies and Serum Avidity in Primary and Secondary Dengue Virus 3 Natural Infections in Humans by Andreas Puschnik (421934)

“…NT₅₀ titers peaked at convalescence and decreased thereafter. …”

Model prediction accuracy. by Dawn Robin Magness (6157265)

Using climate envelope models to identify potential ecological trajectories on the Kenai Peninsula, Alaska by Dawn Robin Magness (6157265)

Myosin phosphatase and RhoA-activated kinase modulate neurotransmitter release by regulating SNAP-25 of SNARE complex by Dániel Horváth (4015034)

“…Inhibition of PP1 with tautomycetin increased, whereas inhibition of ROK by H1152, decreased the phosphorylation of SNAP-25 at Thr138 in B50 cells, in cortical synaptosomes, and in brain slices. …”