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we decrease » _ decrease (Expand Search), mean decrease (Expand Search), teer decrease (Expand Search)
nn decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
0 decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
we decrease » _ decrease (Expand Search), mean decrease (Expand Search), teer decrease (Expand Search)
nn decrease » _ decrease (Expand Search), mean decrease (Expand Search), gy decreased (Expand Search)
0 decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
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Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver.
Published 2021“…(A-B) GCase levels as assessed by the CBE/4-MU method are significantly decreased in the het <i>GBA1</i> D409V KI mice at 5 months of age in both brain (A) and liver (B). …”
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GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age.
Published 2021“…GCase activity measured by 4-MU in brain (A) measured as follows: WT 4mo 27.63±0.68, HOM 4mo 2.53±0.07, WT 8mo 27.65±0.69, HOM 8mo 3.01±0.20, WT 12 mo 27.49±0.46, HOM 12mo 3.15±0.26. …”
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Net work vs phase of activation and lattice spacing. Top) We simulated work loops in the half sarcomere model at phases of activation of 0 to 0.95 in 0.05 increments, as well as over lattice spacings from 12 to 18 nm and plotted the new work for each condition. Bottom) We then simulated work loops over the same range, but with the stiffness of either the linear or torsional spring comprising the crossbridge head increased or decreased by 50% separately....
Published 2025“…Bottom) We then simulated work loops over the same range, but with the stiffness of either the linear or torsional spring comprising the crossbridge head increased or decreased by 50% separately. …”
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