Image_1_Altered Intra- and Inter-Network Connectivity in Drug-Naïve Patients With Early Parkinson’s Disease.tif by Weiqi Zeng (4386472)

“…Intra-network analysis indicated decreased functional connectivity in DGN, SMN, LBN, and ventral attention networks (VAN). …”

Weak Compliance Undermines the Success of No-Take Zones in a Large Government-Controlled Marine Protected Area by Stuart J. Campbell (115219)

“…In the four years following the rezoning reef fish biomass declined across all zones within KNP, with >50% reduction within the no-take Core and Protection Zones. …”

Data Sheet 2_Epidemiological analysis of maternal hypertensive disorders of pregnancy.docx by Aijuan Yuan (21898538)

“…Background<p>We aimed to provide a comprehensive overview of the epidemiology of hypertensive disorders of pregnancy (HDP) from 1990 to 2021, examining incidence and trends across national, continental, and global levels.…”

The Thyroid Receptor Modulator KB3495 Reduces Atherosclerosis Independently of Total Cholesterol in the Circulation in ApoE Deficient Mice by Lisa-Mari Mörk (479563)

“…</p> <p>Objective</p><p>Using ApoE deficient mice, we examined whether KB3495, a TH mimetic compound, reduces atherosclerosis and if there is a synergistic effect with atorvastatin. …”

2‑Ethylhexyl Diphenyl Phosphate and Its Hydroxylated Metabolites are Anti-androgenic and Cause Adverse Reproductive Outcomes in Male Japanese Medaka (Oryzias latipes) by Yu Li (183836)

“…Although high concentrations of 2-ethylhexyl diphenyl phosphate (EHDPP) have been detected in wild fish, its reproductive toxicity in fish remains unclear. In this study, we for the first time observed that EHDPP elicited androgen receptor (AR) antagonistic activity with a 50% inhibitory concentration of 37.5 μM. 2-Ethyl-5-hydroxyhexyl diphenyl phosphate was proved to be the dominant metabolite of EHDPP in Japanese medaka and elicited 3.1-fold stronger AR antagonistic activity than that of EHDPP. …”

Table_3_Species-specific metabolome changes during salinity downshift in sub-Arctic populations of Mytilus edulis and M. trossulus.docx by Inna M. Sokolova (3857770)

“…Taurine emerged as the dominant osmolyte, comprising over 50% of the total free amino acid pool, with aspartate and glycine contributing 15–30%. …”

An Endogenous Aryl Hydrocarbon Receptor Ligand Induces Preeclampsia-like Phenotypes in Rats by Ying-jie Zhao (12873793)

“…ITE increased proteinuria by 50% and decreased uteroplacental blood flow by 26%. …”

Androgen Receptor Functional Analyses by High Throughput Imaging: Determination of Ligand, Cell Cycle, and Mutation-Specific Effects by Adam T. Szafran (269691)

“…</p><h3>Methodology/Principal Findings</h3><p>We report the development of a high throughput (HT) image-based assay that quantifies AR subcellular and subnuclear distribution, and transcriptional reporter gene activity on a cell-by-cell basis. …”

Video_1_Aging dysregulates neutrophil extracellular trap formation in response to HIV in blood and genital tissues.mp4 by Laura Moreno de Lara (12966254)

“…However, how NET formation is triggered by HIV in different tissues and whether this mechanism is affected by aging remain unknown. We demonstrate that the mechanisms that trigger NET release in response to HIV are different in blood and genital tissues, and that NET release decreases with aging. …”

Table_1_A Label-Free Quantitative Proteomic Analysis of Mouse Neutrophil Extracellular Trap Formation Induced by Streptococcus suis or Phorbol Myristate Acetate (PMA).DOC by Xiaoping Wang (110673)

“…Of these peptidases, MMP-8 expression was obviously decreased in response to PMA, but it was not significantly changed in response to S. suis. …”

High glucose induces pyroptosis of retinal microglia through NLPR3 inflammasome signaling by Libin Huang (124637)

“…Results: High-glucose (25, 50, or 100 mM) stimulation decreased cell viability, but enhanced lactate dehydrogenase release and caspase-1 activity in a dose-dependent manner. …”

Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-κB Mediated Inflammation in Colon Cancer Patients by Abdelhabib Semlali (291393)

“…In contrast, the <i>rs2770150</i> is associated with colon cancer in women aged over 50 years and is closely linked with the decreased levels of female sex hormones during the post-menopausal period (OR = 0.188, CI: 0.074–0.48, P = <0.00084). …”

Video_4_Aging dysregulates neutrophil extracellular trap formation in response to HIV in blood and genital tissues.mp4 by Laura Moreno de Lara (12966254)

“…However, how NET formation is triggered by HIV in different tissues and whether this mechanism is affected by aging remain unknown. We demonstrate that the mechanisms that trigger NET release in response to HIV are different in blood and genital tissues, and that NET release decreases with aging. …”

Presentation_1_Neoadjuvant osimertinib and chemotherapy for stage IIIA primary pulmonary carcinosarcoma with EGFR 19DEL mutation: A case report.pptx by Hongming Wang (11756)

“…After the tumor load and size had significantly decreased, radical surgery was successfully performed under thoracoscopy. …”

Integrated analysis reveals important differences in the gut and oropharyngeal microbiota between children with mild and severe hand, foot, and mouth disease by Nan Zhang (46264)

“…Compared with mild HFMD, severe HFMD exhibited significantly decreased diversity and richness of gut microbiota. …”

Novel ENU-Induced Mutation in <i>Tbx6</i> Causes Dominant Spondylocostal Dysostosis-Like Vertebral Malformations in the Rat by Koichiro Abe (39866)

“…However, the variant has decreased transcriptional activation potential in response to Notch-mediated signaling. …”

Image_5_Positive Effects of Neutrophil Elastase Inhibitor (Sivelestat) on Gut Microbiome and Metabolite Profiles of Septic Rats.tif by Yali Sun (2099593)

“…</p>Results<p>Sivelestat administration significantly improved the survival of septic rats (80% vs 50%, P = 0.047). Microbiome analysis showed that the microbiota composition of rats in the CLP group was significantly disturbed, as potential pathogens such as Escherichia-Shigella and Gammaproteobacteria became dominant, and the beneficial microbiota represented by Lactobacillus decreased. …”

A ¹H-NMR Based Study on Hemolymph Metabolomics in Eri Silkworm after Oral Administration of 1-Deoxynojirimycin by Ming-Jie Deng (765440)

“…<div><p>We aimed to investigate whether 1-deoxynojirimycin (DNJ) modulates glycometabolism and has toxicity in Eri silkworm (<i>Samia cynthia ricini</i>, Saturniidae). …”

Image_2_Vitamin A deficiency in the MENA region: a 30-year analysis (1990–2019).JPEG by Saeid Safiri (3713035)

“…The age-standardized prevalence [50.3% (−55.9 to −44.7)] and YLD [−49.3% (−55.3 to −43.1)] rates of VAD have significantly decreased since 1990. …”

Image_5_Experimental evidence of the genetic hypothesis on the etiology of bicuspid aortic valve aortopathy in the hamster model.TIF by María Teresa Soto-Navarrete (3202896)

“…<p>Bicuspid aortopathy occurs in approximately 50% of patients with bicuspid aortic valve (BAV), the most prevalent congenital cardiac malformation. …”