Postnatal Identification of Trisomy 21: An Overview of 7,133 Postnatal Trisomy 21 Cases Identified in a Diagnostic Reference Laboratory in China by Weiwei Zhao (347104)

“…The male/female (M/F ratio) for the total 7,133 Tri21 cases and for the 6,671 cases with non-mosaic standard Tri21 are 1.50 and 1.53 respectively, significantly higher than the 0.93 for all the 247,818 cases we karyotyped, the 1.30 for the Down syndrome (DS) identified during perinatal period in China, and the 1.20 for the livebirth in Chinese population. …”

Data_Sheet_1_Untargeted Metabolomics: Biochemical Perturbations in Golestan Cohort Study Opium Users Inform Intervention Strategies.docx by Yuan-Yuan Li (27693)

“…<p>Objective: Over 50 million people worldwide are estimated to use opioids, of which ~30 million use opiates (opium and its derivatives). …”

Image_1_Relevance of PUFA-derived metabolites in seminal plasma to male infertility.jpeg by Xiangfeng Chen (1548517)

“…</p>Methods<p>From September 2011 to April 2012, We collected semen samples from 564 men aged 18 to 50 years old (mean=32.28 years old)ch., residing in the Sandu County, Guizhou Province, China. …”

Image1_Pharmacogenomic-guided clozapine administration based on HLA-DQB1, HLA-B and SLCO1B3-SLCO1B7 variants: an effectiveness and cost-effectiveness analysis.tiff by Kohei Ninomiya (9369628)

“…By adding the SLCO1B3-SCLO1B7 variant into HLA variants, CIAG sensitivity increased from 36.0% to 43.0%, the specificity decreased from 89.0% to 86.9%, and the probability of cost-effectiveness improved from 74.1% to 87.8%. …”

Image_1_Remarkable impacts of probiotics supplementation in enhancing of the antioxidant status: results of an umbrella meta-analysis.pdf by Vali Musazadeh (12304682)

“…</p>Results<p>Our results indicated that probiotics supplementation meaningfully decreased serum malondialdehyde (MDA) (ES_WMD = −0.56, 95% CI: −0.72, −0.39; p < 0.001, and ES_SMD = −0.50, 95% CI: −0.66, −0.34; p < 0.001). …”

An Early-Onset Subgroup of Type 2 Diabetes: A Multi-Generational, Prospective Analysis in the Framingham Heart Study by Justin B. Echouffo-Tcheugui (9388233)

“…The odds of cardiovascular versus non-cardiovascular death increased with decreasing age of diabetes onset (<i>P</i><0.001 trend). …”

Table_1_Lactate Dehydrogenase as a Potential Therapeutic Drug Target to Control Babesia bigemina.docx by Lan He (219448)

“…Gossypol has a significant (P < 0.0001) inhibitory effect on the in vitro growth of B. bigemina, with IC₅₀ of 43.97 mM after 72 h of treatment. The maximum IC (IC₉₈) was observed at 60 mM gossypol. …”

Table_7_Evidence of a Causal Relationship Between Vitamin D Status and Risk of Psoriasis From the UK Biobank Study.xlsx by Yan Zhang (8098)

“…</p>Results<p>During a median follow-up of 10.99 years, we identified 2,856 participants with incident psoriasis. …”

Image_1_Effects of Perioperative Dexmedetomidine on Immunomodulation in Uterine Cancer Surgery: A Randomized, Controlled Trial.tif by Jin Sun Cho (11710808)

“…Objective<p>Dexmedetomidine has sympatholytic, anti-inflammatory, and analgesic effects and may exert anti-tumor effect by acting on α2A adrenoreceptor. We investigated whether perioperative dexmedetomidine preserves immune function in patients undergoing uterine cancer surgery.…”

Image1_Impacts of moisture supply from the subtropical western Pacific on the subtropical high and the atmospheric river during the heavy rain of 2020 in Japan.PDF by Ning Zhao (84707)

“…However, the actual role of moisture from the subtropical WP region in the AR and heavy rain formations remains unclear. To evaluate that, we conducted a set of numerical sensitivity experiments by adjusting the surface moisture supply over the subtropical WP region with factors of 0%, 50%, and 200%. …”

Image_1_Precision immunointerception of EGFR-driven tumorigenesis for lung cancer prevention.jpeg by Jing Pan (95938)

“…<p>Epidermal growth factor receptor (EGFR) mutations occur in about 50% of lung adenocarcinomas in Asia and about 15% in the US. …”

Image_1_Beyond the Motor Cortex: Thalamic Iron Deposition Accounts for Disease Severity in Amyotrophic Lateral Sclerosis.pdf by Qianwen Li (5369798)

“…</p>Methods<p>A total of 34 patients with ALS (age 51.31 ± 8.24 years, 23 males) and 34 nonneurological controls (age 50.96 ± 9.35 years, 19 males) were enrolled between 2018 and 2020. …”

Osteoporosis and hearing loss: findings from the Korea National Health and Nutrition Examination Survey 2009-2011 by Jun-Il Yoo (6317567)

“…In osteoporosis, the mass of the ossicles will be decreased, affecting the bone density of the cochlea, and interfering with the sound transmission to the cochlea. …”

Supplementary Material for: Estimating the Odds of Ulcerative Colitis-Associated Pyoderma Gangrenosum: A Population-Based Case-Control Study by Kridin K. (10202555)

“…The greatest risk of developing PG occurred in the first years following the diagnosis of UC (OR 35.50, 95% CI 4.35–289.60), and decreased thereafter to 10.03 (95% CI 1.83–55.03), 6.69 (95% CI 1.49–30.02), and 10.03 (95% CI 1.83–55.03) at 1–5, 5–10, and 10–15 years after the diagnosis of UC, respectively. …”

Table_3_Promoting Graduate Student Mental Health During COVID-19: Acceptability, Feasibility, and Perceived Utility of an Online Single-Session Intervention.docx by Akash R. Wasil (9677355)

“…<p>The COVID-19 outbreak has simultaneously increased the need for mental health services and decreased their availability. Brief online self-help interventions that can be completed in a single session could be especially helpful in improving access to care during the crisis. …”

Table1_Anti-depression effectiveness of essential oil from the fruits of Zanthoxylum bungeanum maxim. on chronic unpredictable mild stress-induced depression behavior in mice.docx by Dandan Tang (383577)

“…Meanwhile, for 8 weeks, Sertraline hydrochloride (20 mg/kg/day) and HEO (50, 100, and 150 mg/kg/day) were administered by gavage. …”

Data_Sheet_1_v1_Role of Female Research at the Asociacion Mexicana de Cirugia General Annual Meeting: A Retrospective Analysis From 2013 to 2019.pdf by Lorelí Mejía-Fernández (12539746)

“…Females’ abstracts submitted have a 50 23.5% decreased chance of being selected for oral presentation (OR = 0.765, CI 95%, 0.639–0.917, 51 p = 0.003). …”

Image1_Effects of crude oil and gas condensate spill on coastal benthic microbial populations.JPEG by E. Kababu (14118744)

“…<p>Marine sediments are ecologically-important environments that act as a long-term depository for different contaminants from natural and anthropogenic sources. We investigated the response of crude-oil and gas-condensate spills on benthic microbial populations in the oligotrophic southeastern Mediterranean Sea using costume-design benthocosms. …”

Table 1_The role of serum albumin and albumin-related nutritional indices in predicting post-stroke cognitive impairment: a systematic review and meta-analysis.docx by Yan-qiu Wang (20565725)

“…</p>Methods<p>This study was prospectively registered in PROSPERO (CRD420251012150) and followed the PRISMA guidelines. We systematically searched six databases with a time frame from the date of database establishment to March 29, 2025. …”

A Divergent Artiodactyl <i>MYADM</i>-like Repeat Is Associated with Erythrocyte Traits and Weight of Lamb Weaned in Domestic Sheep by Michael V. Gonzalez (452391)

“…The ovine HapMap project found the same genomic region and the same peak SNP has been under extreme historical selective pressure, demonstrating the importance of this region for survival, reproduction, and/or artificially selected traits. We observed a large (>50 kb) variant haplotype sequence containing a full-length divergent artiodactyl <i>MYADM</i>-like repeat in strong linkage disequilibrium with the associated SNP. …”